A5100693121- Tryptophan and brain disorders
- Traditional Chinese Medicine Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Traditional Chinese Medicine Studies
- Healthcare and Venom Research
- Fungal Biology and Applications
- Exercise and Physiological Responses
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Gut microbiota and health
- Anesthesia and Neurotoxicity Research
- Drug-Induced Hepatotoxicity and Protection
- Neurogenesis and neuroplasticity mechanisms
- Medicinal Plant Pharmacodynamics Research
- Genomics, phytochemicals, and oxidative stress
- SARS-CoV-2 detection and testing
- Morinda citrifolia extract uses
- Bone fractures and treatments
- Pharmacological Effects of Natural Compounds
- COVID-19 and Mental Health
- Ginseng Biological Effects and Applications
- Child and Adolescent Psychosocial and Emotional Development
- Neurological Disease Mechanisms and Treatments
- Herbal Medicine Research Studies
National Institute for Viral Disease Control and Prevention
2024
Beijing University of Chinese Medicine
2018-2023
Qilu Hospital of Shandong University
2023
Children's Hospital of Zhejiang University
2021
Zhejiang Police College
2013
Changchun University
2011
Ginsenoside Rg1 is the principal active ingredient in ginseng. The antidepressant effects of have been validated; however, specific underlying mechanism this effect needs further research. Rats were subjected to chronic restraint stress (CRS) depression model. Rg1, or a positive control drug, was administered rats. Depression-like behaviours evaluated through behavioural experiments. Cytokine, mRNA, protein, ATP, and mitochondria DNA levels detected using indicated methods....
Patients with hypertension have a risk of depression. Morinda officinalis oligosaccharides (MOOs) anti-depressant properties. In this study, we aimed to determine whether MOOs can improve the symptoms depression in individuals hypertension.Dahl salt-sensitive rats fed high-salt diet were stimulated by chronic unpredictable mild stress mimic Primary astrocytes and neurons isolated from these rats. Astrocytes underwent LPS stimulation simulate inflammatory during administrated at 0.1 mg/g/day...
The present study was designed to determine the effects of Ganoderma lucidum polysaccharides (GL-PS) on exhaustive exercise-induced oxidative stress in skeletal muscle tissues mice. mice were divided into four groups (three GL-PS administered and control group). group with distilled water (50, 100 200 mg/kg body weight per day). After 28 days, performed an swimming exercise, along determination superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT) activities...
Adolescents are at a special stage of physical and mental development, which is susceptible period for disorders. Since the outbreak coronavirus pneumonia in December 2019, long term stress may have negative effects on health adolescents. In context disease 2019 (COVID-19), study was designed to investigate psychological adolescents China its possible related factors.A cross-sectional design adopted using structured questionnaire were distributed through Internet measure depression, anxiety,...
Abstract Aim The investigation aims to evaluate the potential effect of Shugan Granule (SGKL) on gut, brain, and behaviors in rats exposed chronic restraint stress (CRS). Methods fecal microbiota metabolite changes were studied CRS treated with SGKL (0.1 mg/kg/day). Depressive these determined through an open‐field experiment, forced swimming test, sucrose preference, weighing. Moreover, LPS‐stimulated microglia CRS‐stimulated investigate regulation between PI3K/Akt/pathway, which is...
Abstract Objective This investigation aims to determine the antidepressant role of Xingpijieyu formula (XPJYF) mediated via gut microbiota (GM)–brain axis. Methods We collected fecal from patients with depressive disorder (DD) and cultured in vitro. Some were transplanted into germ‐free rats intragastric administration XPJYF grain at dose 1.533 g/kg/day. The behaviors studied by forced swimming test, open field sucrose preference body weight. Products hypothalamus–pituitary–adrenocortical...
It was to investigate the neuroprotective mechanism of tanshinone after cerebral infarction via Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related 2 (Nrf2)/antioxidant reaction element (ARE) signaling pathway. Forty specific pathogen-free (SPF) Sprague Dawley (SD) rats were selected, all which male, approximately seven weeks old, weighing 250 ± 25 g. They randomly divided into a model group, non-model operation positive control and an experimental group with ten...
The global sharing of pathogen genome sequences has been significantly expedited by the COVID-19 pandemic. This study aims to elucidate landscape SARS-CoV-2 between 2020 and 2023 with a focus on quantity, timeliness, quality. Specifically, characteristics China are examined.
Through the traditional Chinese medicine inheritance platform system, with help of medical records, Ye Tianshi and Wu Jutong's medication characteristics for summer heat sickness were analyzed, laws two people's summarized, similarities differences between explored to explore relationship. As a result, it was found that both them recognized relationship wetness, Jutong believed "wind" also an important pathogenic factor. Both patients treated cold warm medicine. They used mostly bitter,...
Background and objectives The treatment of somatic symptoms depression is a medical problem nowadays. More more evidences show that oxidative stress mitochondrial dysfunction may be an important pathogenesis are closely related to symptoms. Currently, studies on function mostly concentrated in the brain, with less attention paid peripheral tissues, classical SSRIs not direct antioxidants treatment. XingPiJieYu (XPJY) Decoction one most widely used clinical formulas traditional Chinese...
新型冠状病毒肺炎疫情发生后，世界各国科研机构从多个方向研发新型冠状病毒疫苗，主要有灭活疫苗、减毒活疫苗、重组蛋白疫苗、病毒载体疫苗、核酸疫苗5条研发技术路线。现就新型冠状病毒各型疫苗的优缺点、研发进展与面临的挑战进行综述。.