A5101701696- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Traditional Chinese Medicine Analysis
- Flavonoids in Medical Research
- Medicinal Plant Pharmacodynamics Research
- Pharmacological Effects of Natural Compounds
- Sleep and related disorders
- Neurological Disorders and Treatments
- Sleep and Wakefulness Research
- Nutrition, Genetics, and Disease
- Mitochondrial Function and Pathology
- Treatment of Major Depression
- Microbial Metabolism and Applications
- Biological Research and Disease Studies
- Restless Legs Syndrome Research
- Protein Tyrosine Phosphatases
- Tryptophan and brain disorders
- Medicinal Plants and Neuroprotection
- Biochemical effects in animals
- Morinda citrifolia extract uses
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Viral Infections and Immunology Research
- Advanced Proteomics Techniques and Applications
- Olfactory and Sensory Function Studies
Beijing University of Chinese Medicine
2011-2024
Hangzhou Seventh Peoples Hospital
2022
Beijing Fengtai Hospital
2016
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2012
Patients with hypertension have a risk of depression. Morinda officinalis oligosaccharides (MOOs) anti-depressant properties. In this study, we aimed to determine whether MOOs can improve the symptoms depression in individuals hypertension.Dahl salt-sensitive rats fed high-salt diet were stimulated by chronic unpredictable mild stress mimic Primary astrocytes and neurons isolated from these rats. Astrocytes underwent LPS stimulation simulate inflammatory during administrated at 0.1 mg/g/day...
Vascular cognitive impairment (VCI) encompasses a range of deficits arising from vascular pathology. The pathophysiological mechanisms underlying VCI remain incompletely understood; however, chronic cerebral hypoperfusion (CCH) is widely acknowledged as principal pathological contributor. Mitochondria, crucial for cellular energy production and intracellular signaling, can lead to numerous neurological impairments when dysfunctional. Recent evidence indicates that mitochondrial...
The bioactive components and potential targets of BHD were screened by TCMSP, BATMAN-TCM, ETCM, SymMap databases. Besides, compounds that failed to find the from above databases predicted through STITCH, SwissTargetPrediction, SEA. Moreover, six searched mine IS. intersection obtained analyzed GO KEGG enrichment. Furthermore, BHD-IS PPI network, compound-target herb-target-pathway network constructed Cytoscape 3.6.0. Finally, AutoDock was used for molecular docking verification.A total 235...
Abstract Background Synaptic damage and glutamate excitotoxicity have been implicated in the pathogenesis of vascular dementia (VD). Clathrin, RAB5B N -methyl- d -aspartic acid receptor 1 (NMDAR1) proteins play a vital role endocytosis synaptic vesicles neurons over accumulation. Previous researches confirmed that Shenzhi Jiannao (SZJN) formula has an anti-apoptotic neuroprotective effect VD, but underlying mechanisms are still unclear. In this study, we aimed to explore SZJN on cognitive...
Abstract Introduction Insomnia was widely distributed among the population, and it a risk factor for many diseases. To evaluate condition of usage drugs in Chinese hospital Longgang, Shenzhen, we carried this cross-sectional research. We extracted information drug usage, symptoms patients by R software (version 4.0.2) from Hospital Information System (HIS). The research registered Clinical Trial Registry, ChiCTR2000040703. Methods A retrospective, study conducted Shenzhen Beijing University...
Background and purpose: This study was undertaken to investigate the development changes of myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation expression in acute ischemia hippocampus cortex, establish relationship between these damage.Methods: The multi-cerebral infarction model established by method Kaneko.The histopathological analyses observed microscope (HE staining).The MARCKS p-MARCKS protein were surveyed western blot technic immunohistochemical test...
Abstract Background and objective: With the exact clinical efficacy, Buyang Huanwu decoction (BHD) is a classical prescription for treatment of ischemic stroke (IS). Here, we aimed to investigate pharmacological mechanisms BHD in treating IS using systems biology approaches. Methods: The bioactive components potential targets were screened by TCMSP, BATMAN-TCM, ETCM, SymMap databases. Besides, compounds that failed find from above databases predicted through STITCH, SWISS, SEA. Moreover, six...
Abstract Introduction Insomnia was widely distributed among the population, and it a risk factor for many diseases. To evaluate condition of usage drugs in Chinese hospital Longgang, Shenzhen, we carried this cross-sectional research. We extracted information drug usage, symptoms patients by R software (version 4.0.2) from Hospital Information System (HIS). The research registered Clinical Trial Registry, ChiCTR2000040703. Methods A retrospective, study conducted Shenzhen Beijing University...
Abstract Background: Synaptic damage and glutamate excitotoxicity have been implicated in the pathogenesis of vascular dementia (VD). Clathrin, RAB5B N-methyl-d-aspartic acid receptor 1 (NMDAR1) proteins play a vital role endocytosis synaptic vesicles neurons over accumulation. Previous researches confirmed that Shenzhi Jiannao (SZJN) formula has an anti-apoptotic neuroprotective effect VD, but underlying mechanisms are still unclear. In this study, we aimed to explore SZJN on cognitive...