Butein (3,4,2',4'-tetrahydroxychalcone) is a polyphenol derived from various natural plants and capable of inducing several types death in cancer cells. However, the molecular mechanisms underlying butein-induced breast cell apoptosis remain unknown. The present study aimed to prove that butein inhibits proliferation MDA-MB‑231 human cells dose- time-dependent manner. markedly induced generation reactive oxygen species (ROS), decreased phosphorylation extracellular signal-regulated kinase...

The bioactive components and potential targets of BHD were screened by TCMSP, BATMAN-TCM, ETCM, SymMap databases. Besides, compounds that failed to find the from above databases predicted through STITCH, SwissTargetPrediction, SEA. Moreover, six searched mine IS. intersection obtained analyzed GO KEGG enrichment. Furthermore, BHD-IS PPI network, compound-target herb-target-pathway network constructed Cytoscape 3.6.0. Finally, AutoDock was used for molecular docking verification.A total 235...

Abstract Background: Guillain-Barre syndrome (GBS) is a disease with the features of acuteness, paralysis, inflammation, and in peripheral nerves. There are many current treatment options varying efficacy, to assess their effectiveness, we performed network meta-analysis (NMA). The study protocol was registered at PROSPERO (CRD: 42019119178). Posted history: this manuscript previously posted medRxiv: doi: https://doi.org/10.1101/2020.06.03.20121780. Methods: literature search database...

Shenzhi Jiannao (SZJN) prescription is a type of herbal formula adopted in the management cognitive impairment and related disorders. However, its effects regulatory mechanisms on vascular dementia (VD) are elusive. Herein, network pharmacology prediction was employed to explore pharmacological molecular SZJN VD using prediction, validated results through vitro experiments.Through search Traditional Chinese Medicine Systems Pharmacology Database Analysis Platform (TCMSP) database, chemical...

Along with the rapid development of economy and urbanization, noise air pollution are becoming major occupational health hazards in process industrial production. In this study, we collected data from 7293 workers China. The association between exposure dust blood pressure was investigated. Controlling for demographic variables, including sex, age, length service, a stepwise regression model backward elimination constructed. results showed that both decreased level systolic (p < 0.001). This...

Abstract Background Synaptic damage and glutamate excitotoxicity have been implicated in the pathogenesis of vascular dementia (VD). Clathrin, RAB5B N -methyl- d -aspartic acid receptor 1 (NMDAR1) proteins play a vital role endocytosis synaptic vesicles neurons over accumulation. Previous researches confirmed that Shenzhi Jiannao (SZJN) formula has an anti-apoptotic neuroprotective effect VD, but underlying mechanisms are still unclear. In this study, we aimed to explore SZJN on cognitive...

<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Objective</i> : Multivariate signal (MS) analysis, especially the assessment of its information transmission (for example, from perspective network science), is key to our understanding various phenomena in biology, physics and economics. Although there a large amount literature demonstrating that MS can be decomposed into space-time-frequency domain information, seems no research confirming...

Abstract The accurate extraction of tunnel centerline and cross-section plays a vital role in many deformation monitoring projects. To address this issue, An automatic data method for is proposed based on the three-dimensional laser scanning data. A k-dimensional tree index first constructed horizontal projection point clouds, then series seed points selected as center several neighborhood sets with different radii; difference set region, which will be used to calculate convex hull...

Abstract Background Xingnaojing injection (XNJ) is extracted from the Chinese ancient prescription “An-Gong-Niu-Huang Pill”, widely used for stroke in China. We mainly observe effect of XNJ (Xingnaojing) on gut microbiota model mice. Methods Forty-two 7-to 8-week-old male C57 mice weighing 22-24 g were chosen experiment. There 6 each group; 7 groups normal group (NG), MCAO (CG), MCAO+XNJ (EG), sham surgery (SG), germ-free (SGFNG), germ-free+MCAO (SGFCG), and germ-free+MCAO+XNJ (SGFEG). Two...

Abstract Background Guillain-Barre syndrome (GBS) is an acute, paralyzing, inflammatory peripheral nerve disease. For treatments of the Syndrome, there are many kinds therapies for this diseases. comparing all therapies, such as immunoglobulin, plasma exchanging, etc. in treatment Syndrome(GBS) to better inform clinical practice, we use Network meta analysis get outcome Syndrome. The protocol has been submitted PROSPERO:CRD: 42019119178. Methods Web Science, PubMed, Embase, and Cochrane...

Dawn song is very sensitive to the environmental factors, including both natural factors and anthropogenic ones. To examine relationship between singing behavior of Varied Tits dominant we recorded dawn songs (Parus varius varius). The results showed that: (1) began earlier as sunrise time started earlier; (2) start was later sing strength lower in cloudy days than that sunny days; (3) varied across different lunar cycle phases; (4) acoustic parameters typical significantly, frequency...

<h3>Background</h3> In patients (pts) with rheumatoid arthritis (RA) treated ABT-494, dose-dependent increases in levels of low and high density lipoprotein cholesterol (LDL-C HDL-C) were observed, along decreases C-reactive Protein (CRP). Whether these changes are due to the control inflammation or a direct effect on CRP production liver is not known. <h3>Objectives</h3> To explore relationship between HDL-C LDL-C ABT-494 treatment, assess whether lipids dependent improvement RA signs...

Freezing of Gait (FOG) significantly impacts daily activities Parkinson's disease (PD) patients. Despite the potential wearable sensors in predicting FOG, challenges persist, including brief prediction interval before FOG onset, limited generalization across patients, and inconvenience multiple sensors. Addressing one issue often aggravates others, making it difficult to achieve suitable concurrent solutions all these challenges. We introduce PhysioGait Predictive Network (PhysioGPN), a deep...

To explore the brain protection mechanism of Xingnaojing injection (XNJ) against ischemic stroke (IS) by network pharmacology approach and gut microbiota analysis.We used analysis to identify active components XNJ its potential targets IS inflammatory bowel disease (IBD) carried out analysis, functional annotation, pathway enrichment analysis. Then, transient middle cerebral artery occlusion (tMCAO) mice model was verify molecular XNJ.36 compounds were identified from XNJ, effect related...

Abstract Introduction Insomnia was widely distributed among the population, and it a risk factor for many diseases. To evaluate condition of usage drugs in Chinese hospital Longgang, Shenzhen, we carried this cross-sectional research. We extracted information drug usage, symptoms patients by R software (version 4.0.2) from Hospital Information System (HIS). The research registered Clinical Trial Registry, ChiCTR2000040703. Methods A retrospective, study conducted Shenzhen Beijing University...

Objective: To evaluate the safety, tolerability, and efficacy of milnacipran following a direct switch from duloxetine in fibromyalgia (FM) patients with inadequate response to duloxetine. Background Milnacipran are approved for management FM. As individual patient responses analgesic medications differ, switching therapies achieve greater benefit or avoid certain side effects is common. Design/Methods: Patients receiving 60 mg/day ≥4 weeks at screening were eligible. After 2 open-label...

Abstract Background Guillain-Barre syndrome (GBS) is an acute, paralyzing, inflammatory peripheral nerve disease. For treatments of the Syndrome, there are many kinds therapies for this diseases. comparing all therapies, such as immunoglobulin, plasma exchanging, etc. in treatment Syndrome(GBS) to better inform clinical practice, we used Network meta analysis get outcome Syndrome. The protocol had been submitted PROSPERO:CRD: 42019119178. Methods Web Science, PubMed, Embase, and Cochrane...

Abstract Background and objective: With the exact clinical efficacy, Buyang Huanwu decoction (BHD) is a classical prescription for treatment of ischemic stroke (IS). Here, we aimed to investigate pharmacological mechanisms BHD in treating IS using systems biology approaches. Methods: The bioactive components potential targets were screened by TCMSP, BATMAN-TCM, ETCM, SymMap databases. Besides, compounds that failed find from above databases predicted through STITCH, SWISS, SEA. Moreover, six...