A5071607009- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Olfactory and Sensory Function Studies
- Neurotransmitter Receptor Influence on Behavior
- Neurogenesis and neuroplasticity mechanisms
- Proteoglycans and glycosaminoglycans research
- Biochemical Analysis and Sensing Techniques
- Biochemical effects in animals
- Neuropeptides and Animal Physiology
- Circadian rhythm and melatonin
- Orthopaedic implants and arthroplasty
- Antioxidants, Aging, Portulaca oleracea
- Phytochemical Studies and Bioactivities
- Neuroendocrine regulation and behavior
- Cell death mechanisms and regulation
- Cell Adhesion Molecules Research
- Total Knee Arthroplasty Outcomes
- Neurological disorders and treatments
- Pharmacological Effects and Toxicity Studies
- Adipose Tissue and Metabolism
- Nerve injury and regeneration
Chung Shan Medical University
2016-2025
Chung Shan Medical University Hospital
2012-2024
National Taiwan University
2000-2004
Far Eastern Memorial Hospital
2001
The elevated plus-maze (EPM) test is one of the most commonly used behavioral assays to evaluate anxiety-related behavior in rodents. It an economic (5 min duration) without prior conditioning animals. critical measure for anxiety time spent open arms maze. A confounding problem EPM so called one-trial tolerance (OTT), characterized by a marked decrease arm exploration spite treatment with anxiolytic acting benzodiazepines upon re-exposure EPM. This consistent finding often raised as...
Introduction Cancer-related fatigue (CRF) is a common symptom induced by chemotherapy. The main objective of the present study was to investigate whether quercetin regulates hypothalamic-pituitary-adrenal (HPA) axis and chemoattractant protein-1 (MCP-1) signaling, two factors contributing CRF in mice exposed cisplatin. Methods Male BALB/c were randomly assigned following five groups for 15 weeks: Control, CDDP, CDDP+TAK779 (an antagonist MCP-1 receptor, human CC chemokine receptor R2...
The role of individual factors in behavioral neuroscience is an important, but still neglected, area research. For example, the Elevated Plus-Maze Test has been one most used paradigms to gauge unconditioned aversively motivated behavior rodents. However, despite a great number experiments with this test there have only few efforts assess systematic variations elevated plus-maze and related neurobiological functions. present review aims give, first, general overview introduction about test,...
It is unclear whether cardiac hypertrophy and hypertrophy-related pathways will be induced by long-term intermittent hypoxia. Thirty-six Sprague-Dawley rats were randomly assigned into three groups: normoxia, hypoxia (12% O(2), 8 h per day) for 4 weeks (4WLTIH) or (8WLTIH). Myocardial morphology, trophic factors signalling in the groups determined heart weight index, histological analysis, Western blotting reverse transcriptase-polymerase chain reaction from excised left ventricle. The ratio...
Animal models of Parkinson's disease with dementia would greatly facilitate research into the underlying causes this disorder. Here, we showed that bilateral infusion 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) substantia nigra pars compacta (SNc) Wistar rats caused degeneration nigrostriatal dopaminergic neurons, cell loss in hippocampal CA1 area, as well microglial activation and increase interleukin-2 levels several brain regions. In addition, anxiety-like behavior impairment...
Butein (3,4,2',4'-tetrahydroxychalcone) is a polyphenol derived from various natural plants and capable of inducing several types death in cancer cells. However, the molecular mechanisms underlying butein-induced breast cell apoptosis remain unknown. The present study aimed to prove that butein inhibits proliferation MDA-MB‑231 human cells dose- time-dependent manner. markedly induced generation reactive oxygen species (ROS), decreased phosphorylation extracellular signal-regulated kinase...
Abstract Prolonged exposure to gamma‐hydroxybutyric acid ( GHB ) would cause drug intoxication in which impaired cognitive function results from enhanced hippocampal oxidative stress may serve as a major symptom this deficiency. Considering melatonin possesses significant anti‐oxidative efficacy, study aimed determine whether successfully promote the nuclear factor erythroid 2‐related 2 and antioxidant responsive element (Nrf2‐ ARE signaling, depress stress, rescue bioenergetics following...
The purpose of this study was to evaluate the effects diosgenin on D-galactose-induced cerebral cortical widely dispersed apoptosis. Male 12-week-old Wistar rats were divided into four groups: Control (1[Formula: see text]mg/kg/day saline, i.p.), DD0 (150[Formula: D-galactose, DD10, and DD50 (D-galactose[Formula: text] or 50[Formula: orally). After eight weeks, histopathological analysis, positive TUNEL Western blotting assays performed excised cortex from all groups. TUNEL-positive...
Substance use disorder (SUD) exacerbates the impact of Long-COVID, particularly increasing risk taste and olfactory disorders. Analyzing retrospective cohort data from TriNetX over 33 million records (Jan 2020-Dec 2022), this study focused on 1,512,358 participants, revealing that SUD significantly heightens likelihood experiencing disturbances anosmia in Long-COVID sufferers. Results indicated individuals with face a higher incidence sensory impairments compared to controls, older adults...
Subcutaneous (s.c.) D-galactose (DG) treatment has been shown to facilitate the development of biomarkers for Alzheimer's disease in C57BL/6J mice. The aim present study was determine whether this young BALB/cJ mice, another mouse strain, enhanced oxidative stress similar extents older and further effects fructo-oligosaccharide (FO), a prebiotic fibre vitamin E (antioxidant control) on DG-induced damage lipids, proteins mitochondrial DNA, erythrocyte antioxidant enzyme activities. Mice (12...