Abstract Background Biological markers of treatment response may include structural brain changes seen on neuroimaging. While most imaging studies have focused cerebrovascular disease, evidence is growing that the hippocampus play a role in depression, particularly geriatric depression. Method We studied 60 depressed elderly patients enrolled longitudinal study who were treated with antidepressant medications using guideline‐based approach. Baseline and 12‐week Montgomery‐Asberg Depression...

Aims and objectives. To examine the level of quality life in individuals with schizophrenia to test its association socio‐demographic, clinical psychosocial characteristics. Background. Quality has been a focus concern mental health care, yet determinants for are not well known. Design. Cross‐sectional, descriptive design. Methods. A total 148 participated study. demographic information sheet, 18‐item Brief Psychiatric Rating Scale, Chinese Health Questionnaires, Mutuality Scale World...

Our study aimed to clarify the neuroimaging correlates of suicide attempt by comparing differences in functional magnetic resonance imaging (fMRI) among depressed attempters, patients without history, and healthy controls through comprehensive novel fMRI analyses methods same population. The association between depression severity aspects brain was also discussed. recruited 109 participants who were assigned three groups: 33 with (SA), 32 (NS), 44 (HC). All scanned using a 3 T MRI system...

Drug-induced taste disturbances are prevalent in clinical practice, with dysgeusia being a frequent manifestation. This study aims to present case of disorders and tongue numbness induced by lithium overdose.A 33-year-old woman bipolar II disorder attempted suicide ingesting multiple drugs, including benzodiazepines. She exhibited weakness but was conscious after admission. Laboratory analyses indicated elevated serum urine benzodiazepine levels. Admitted psychiatric ward, her symptoms...

Enterovirus (EV) infection is common among children and adolescents. Few studies have investigated the relationship of depression after EV infection. This study explores an association between subsequent in adolescents assesses risk with central nervous system involvement a nationwide population-based retrospective cohort. A random sample 1,000,000 people was derived from Taiwan National Health Insurance Research Database we identified enrollees less than 18 years before 2005 followed up...

The long noncoding RNA, Growth arrest-specific 5 (GAS5) plays a crucial role in the development of oral cancer. However, potential genetic variants GAS5 that affect susceptibility and progression cancer have rarely been explored. In this study, two loci single nucleotide polymorphisms (SNPs) (rs145204276 rs55829688) were genotyped by using TaqMan allelic discrimination 1125 patients 1195 non-oral-cancer individuals. After statistical analyses, distribution both SNP rs145204276 rs55829688...

Abstract Objective To evaluate the overall long-term effectiveness of aripiprazole in patients with schizophrenia a general psychiatric practice setting Taiwan. Methods This was prospective, open-label, multicenter, post-market surveillance study Taiwanese Diagnostic and Statistical Manual Mental Disorders, Fourth Edition (DSM-IV) diagnosis or schizoaffective disorder requiring switch antipsychotic medication because current not well tolerated and/or clinical symptoms were controlled....

Oral cancer is the eighth greatest generally diagnosed amongst males worldwide and fourth most malignancy Taiwanese males.The pro-inflammatory adipocytokine visfatin promotes tumor growth.Elevated plasma levels have been identified in patients with oral squamous cell carcinoma (OSCC), although biological mechanisms underlying involvement of pathogenesis OSCC are not well understood.Moreover, no information available regarding associations between polymorphisms carcinogenic lifestyle factors...

Parallel abstracts Neuroimmune system is involved in communication between the endocrine and nervous systems, which may take part effects of dioscorea, reversing changes anxiety-like behavior interleukin (IL)-2 levels brains ovariectomized (OVX) rats. This study was aimed at evaluating administration diosgenin, an ingredient on neuroimmune behavioral functions OVX animals. One month after ovariectomy, female Wistar rats were fed daily with diosgenin (0, 10, 50 or 100 mg/kg/day) elevated...

Colorectal cancer (CRC) is a multifactorial malignancy, and its high incidence mortality rate remain global public health burden. Fibroblast growth factor receptor 4 (FGFR4) tyrosine kinase that has been shown to play key role in development prognosis via the activation of downstream oncogenic signaling pathways. The present study aimed explore impact FGFR4 gene polymorphisms on risk progression CRC. Three single-nucleotide (SNPs), including rs1966265, rs351855, rs7708357, were evaluated 413...

Bone and joint surgery is widely used in orthopedic, oral, maxillofacial, dental plasty departments to correct bone pathology such as tumors fractures, skeletal morphological deformities. This article presents a voxel structure represent topologically geometrically surfaces algorithms accurately compute intersections of tool swept with bones based on this structure. then various volume manipulation operate virtual bones, grafts, prostheses for simulations. A complicated knee arthroplasty...

The aim of the current study was to evaluate combined effect single nucleotide polymorphism (SNP) in long non-coding RNA growth arrest-specific 5 (GAS5) and phenotypes epidermal factor receptor (EGFR) on clinicopathological characteristics lung adenocarcinoma. present examined relationship between GAS5 single-nucleotide polymorphisms (SNPs; rs145204276 Ins/Del, rs55829688 T/C) factors 539 adenocarcinoma patients with or without EGFR mutations. We found that genotype distributions two SNPs...

Differences in child abuse perpetration between individuals with and without mental disorders remain obscure. This study compared the risk difference further investigated association category of perpetration. A total 681,970 adults from 2002 to 2013 Taiwan National Health Insurance Research Database were analyzed, including 340,985 patients psychiatric (International Classification Diseases, Ninth Revision, Clinical Modification [ICD-9-CM] codes 290.x–319.x) sex- age-matched disorders. Child...

Abstract Purpose To examine the effects of a brief family strengths‐oriented therapeutic conversation (FAM‐SOTC) intervention on symptom severity patients with schizophrenia and coping caregiver burden for caregivers. Design A quasi‐experimental research design repeated measures. Methods convenience sample 72 dyads patient‐family caregivers was recruited from randomized inpatient psychiatric rehabilitation units in hospital Taiwan. Sixty‐one that comprised group ( n = 29) control 32)...

To investigate the distribution of single nucleotide polymorphism (SNP) tissue inhibitor metalloproteinases-3 (TIMP-3) in patients with/without urothelial cell carcinoma (UCC), three loci TIMP-3 SNPs (rs9862 C/T, rs9619311 T/C, rs11547635 C/T) were genotyped via TaqMan allelic discrimination for 424 UCC and 848 non-UCC participants.Furthermore, mRNA expression its correlation with clinical characters bladder was analyzed using The Cancer Genome Atlas database (TCGA).The all 3 studied...

The aims of this study were to explore the involvement Aurora kinase A (AURKA) gene single nucleotide polymorphisms (SNPs) in uterine cervical cancer that has not yet been investigated.One hundred and six patients with invasive 94 precancerous lesions, 302 Taiwanese female individuals included.AURKA SNPs rs2273535, rs6024836, rs2064863 rs1047972 analyzed for genotypic distributions using real-time polymerase chain reaction.There no statistically significant differences genetic frequencies...

Abstract Alzheimer's disease (AD) is the most common form of dementia. H. pylori infection and overweight have been implicated in AD via gut-brain axis (GBA). This study aimed to determine supplementation BRBs has a meaningful effect on infection, development clinical trial setting. We conducted randomized placebo-controlled patients with mild dementia who also had overweight. The was carried out over 10 weeks, consisting an 8-week intervention period (25g powder black raspberries, BRBs, or...