A5080149007- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Protease and Inhibitor Mechanisms
- Oral Health Pathology and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Peptidase Inhibition and Analysis
- Sirtuins and Resveratrol in Medicine
- Cell death mechanisms and regulation
- Cancer-related gene regulation
- Natural product bioactivities and synthesis
- Cancer Mechanisms and Therapy
- Oral and Maxillofacial Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Bioactive natural compounds
- RNA modifications and cancer
- Sinusitis and nasal conditions
- Ear and Head Tumors
- MicroRNA in disease regulation
- Genomics, phytochemicals, and oxidative stress
- Meningioma and schwannoma management
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Natural Compounds in Disease Treatment
National Chung Hsing University
2022-2024
Changhua Christian Hospital
2015-2024
Chung Shan Medical University
2013-2022
Weatherford College
2015
MingDao University
2009-2013
Taipei Medical University
2013
Zero to Three
2009
Chang Jung Christian University
2006-2008
Health risks stemming from betel-quid (BQ) chewing are frequently overlooked by people. Updated epidemiological data on the increased BQ use among Asian populations using comparable collection methods have not been widely available. To investigate prevalence, patterns of practice and associated types oral preneoplastic disorders, an intercountry Betel-quid Consortium study (the ABC study) was conducted for Taiwan, Mainland China, Malaysia, Indonesia, Nepal Sri Lanka. A random sample 8,922...
BACKGROUND To reduce oral cancer mortality, an organized, population‐based screening program for the early detection of premalignancy and was designed high‐risk individuals with habits betel quid chewing, cigarette smoking, or both. The objective this report to evaluate long‐term effectiveness in reducing incidence advanced disease deaths from cancer. METHODS A nationwide, has been conducted Taiwan since 2004. Residents aged ≥ 18 years smoking and/or chewing were invited. standardized...
Oral squamous cell carcinoma (OSCC), an epithelial malignancy affecting a variety of subsites in the oral cavity, is prevalent Asia.The survival rate OSCC patients has not improved over past decades due to its heterogeneous etiology, genetic aberrations, and treatment outcomes.Improvement therapeutic strategies tailored options unmet need.To unveil mutational spectrum, whole-exome sequencing 120 from male individuals Taiwan was conducted.Analyzing contributions five signatures extracted...
Background Kaempferol has been proposed as a potential drug for cancer chemoprevention and treatment because it is natural polyphenol contained in plant-based foods. Recent studies have demonstrated that kaempferol protects against cardiovascular disease cancer. Based on this finding, we investigated the mechanisms by which produces anti-metastatic effect human tongue squamous cell carcinoma SCC4 cells. Methodology/Principal Findings In study, provided molecular evidence associated with of...
Abstract Background Capsaicin, a pungent phytochemical in variety of red peppers the genus Capsicum , has shown an anti-proliferative effect on various human cancer cell lines. In contrast, capsaicin also been considered to promote growth cells. Thus, effects types need be explored. The KB cells are still unknown. Therefore, we examined viability, cycle progression, and factors associated with apoptosis treated capsaicin. Methods proliferation/viability cytotoxicity exposed were determined...
High mortality and morbidity rates for hepatocellular carcinoma in Taiwan primarily result from uncontrolled tumour metastasis. Glabridin, a prenylated isoflavonoid of licorice (Glycyrrhiza glabra) roots, is associated with wide range biological properties, such as regulation energy metabolism, oestrogenic, neuroprotective, anti-osteoporotic skin whitening. However, the effect glabridin on metastasis cells has not been clarified.A wound healing model Boyden chamber assays vitro were used to...
Multidrug resistance (MDR) is the of cells toward various drugs commonly used in tumor treatment. The mechanism drug oral cancer not completely understood. Melatonin an endogenously produced molecule involved active biological mechanisms including antiproliferation, oncogene expression modulation, antitumor invasion and migration, anti-inflammatory, antioxidant, antiangiogenic effects. Despite these functions, effects melatonin on vincristine (VCR)-resistant human remain largely unknown....
Abstract BACKGROUND Heterogeneity of primary tumor volume within tumors the same classification indicates a need to elucidate effects on treatment outcomes in patients with nasopharyngeal carcinoma (NPC). METHODS From 1994 through 1996, 129 newly diagnosed NPC who were treated high‐dose radiotherapy enrolled study. Computed tomography‐derived was measured using summation‐of‐area technique. Correlations between American Joint Committee Cancer (AJCC) disease stage, volume, and disease‐specific...
Oral squamous cell carcinoma has a striking tendency to migrate and metastasize. Cyclooxygenase (COX)-2, the inducible isoform of prostaglandin (PG) synthase, been implicated in tumor metastasis. However, effects COX-2 on human oral cancer cells are largely unknown. We found that overexpression or exogenous PGE(2) increased migration intercellular adhesion molecule 1 (ICAM)-1 expression cells. Using pharmacological inhibitors, activators, genetic inhibition EP receptors, we discovered EP1...
To study the efficacy of endoscopic nasopharyngectomy in salvaging recurrent T1 to 2a nasopharyngeal carcinoma (NPC).An investigation outcome nasopharyngectomy.Six nasopharyngectomies for patients presenting with locally NPC were performed exclusively by way resection a single surgeon (m.-k.c.) during period 2001 2005. All operated on curative intent without postoperative radiotherapy.All six operations successfully endoscopically, and no conversions conventional open necessary. Of who...
Background Cathepsin B (CTSB), a member of the cathepsin family, is cysteine protease that widely distributed in lysosomes cells various tissues. It overexpressed several human cancers and may be related to tumorigenesis. The main purpose this study was analyze CTSB expression oral squamous cell carcinoma (OSCC) its correlation with patient prognosis. Methodology/Principal Findings Tissue microarrays were used detect 280 patients examine association between clinicopathological parameters. In...
Background Naturally occurring agents, such as resveratrol, have been determined to benefit health. Numerous studies demonstrated that resveratrol has antioxidative, cardioprotective, and neuroprotective properties. However, the effect of exerts on metastasis oral cancer cells remains unclear. In this study, we investigated anti‐invasive activity a human cell line ( SCC ‐9) in vitro underlying mechanisms. Methods Cell viability was examined by MTT assay, whereas motility measured migration...
Abstract Oral cancer is one of the most common cancers in world. Approximately 90% oral are subtyped to squamous cell carcinoma (OSCC). Despite advances diagnostic techniques and improvement treatment modalities, prognosis remains poor. Therefore, an effective chemotherapy mechanism that enhances tumor sensitivity chemotherapeutics urgently needed. Methyl protodioscin (MP) a furostanol bisglycoside with wide range beneficial effects, including anti-inflammatory anti-cancer properties. The...