A5014260545- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Glaucoma and retinal disorders
- RNA modifications and cancer
- Blood Coagulation and Thrombosis Mechanisms
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Cell death mechanisms and regulation
- Enzyme function and inhibition
- Oral Health Pathology and Treatment
- Cell Adhesion Molecules Research
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Oral microbiology and periodontitis research
- Cancer-related Molecular Pathways
- Circadian rhythm and melatonin
- Regulation of Appetite and Obesity
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- Curcumin's Biomedical Applications
- Phytochemical compounds biological activities
- Genomics, phytochemicals, and oxidative stress
Chung Shan Medical University Hospital
2016-2025
Chung Shan Medical University
2016-2025
Nobel Foundation
2025
Chang Bing Show Chwan Memorial Hospital
2023
Taichung Veterans General Hospital
2019
China Medical University
2019
China Medical University
2018
China Medical University Hospital
2018
Shanxi Medical University
2018
Changhua Christian Hospital
2017
Abstract Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of oral cavity and fourth leading malignancy cause cancer-related death in male population Taiwan. Most cases are detected at advanced stages, resulting poor prognosis. Therefore, improved detection early health disorders indispensable. The involvement bacteria inflammation their association with OSCC progression provide a feasible target for diagnosis. Due to nature neoplasms, diagnosis epithelial precursor...
Abstract Abstract: Dietary polyphenols, including anthocyanins, are suggested to be involved in the protective effects of fruits and vegetables against cancer. However, anticancer peonidin 3-glucoside have not been clearly demonstrated, with only limited studies being available concerning inhibitory effect cyanidin for tumor cell growth. Therefore, this study, we isolated identified two bioactive compounds, 3-glucoside, from Oryza sativa L. indica, treat various cancer cells. The results...
Renal cell carcinoma (RCC) is the most lethal of all urological malignancies because its potent metastasis potential. Melatonin exerts multiple tumor-suppressing activities through antiproliferative, proapoptotic, and anti-angiogenic actions has been tested in clinical trials. However, antimetastastic effect melatonin underlying mechanism RCC are unclear. In this study, we demonstrated that at pharmacologic concentration (0.5-2 mm) considerably reduced migration invasion cells (Caki-1 Achn)....
Oral squamous cell carcinoma (OSCC), an epithelial malignancy affecting a variety of subsites in the oral cavity, is prevalent Asia.The survival rate OSCC patients has not improved over past decades due to its heterogeneous etiology, genetic aberrations, and treatment outcomes.Improvement therapeutic strategies tailored options unmet need.To unveil mutational spectrum, whole-exome sequencing 120 from male individuals Taiwan was conducted.Analyzing contributions five signatures extracted...
Background Kaempferol has been proposed as a potential drug for cancer chemoprevention and treatment because it is natural polyphenol contained in plant-based foods. Recent studies have demonstrated that kaempferol protects against cardiovascular disease cancer. Based on this finding, we investigated the mechanisms by which produces anti-metastatic effect human tongue squamous cell carcinoma SCC4 cells. Methodology/Principal Findings In study, provided molecular evidence associated with of...
Abstract Dysbiosis of oral microbiome may dictate the progression squamous cell carcinoma (OSCC). Yet, composition fluctuates by saliva and distinct sites cavity is affected risky behaviors (smoking, drinking betel quid chewing) individuals’ health condition. To characterize disturbances in microbial population mainly due to tumorigenicity, we profiled bacteria within surface OSCC lesion its contralateral normal tissue from discovery (n = 74) validation 42) cohorts male patients with cancers...
Osteosarcomas, the most common malignant bone tumors, show a potent capacity for local invasion and pulmonary metastasis. Resveratrol (RESV), phytochemical, exhibits multiple tumor-suppressing activities has been tested in clinical trials. However, antitumor of RESV osteosarcomas are not yet completely defined. In osteosarcoma cells, we found that inhibited migration/invasion vitro lung metastasis vivo by suppressing matrix metalloproteinase (MMP)-2. We identified exhibited transcriptional...
Nasopharyngeal carcinoma (NPC), a disease common in the South-East Asian population, has high lymph node metastatic ability. Melatonin, an endogenously produced substance present animals, plants, fungi, and bacteria, oncostatic activity via several mechanisms. The molecular mechanisms involved melatonin-mediated tumor inhibitory potential are not completely defined. Here, we show that melatonin treatment inhibits TPA-induced cell motility by regulating matrix metalloproteinase-9 (MMP-9)...
Hispolon, a phenolic compound isolated from Phellinus igniarius, induces apoptosis and anti-tumor effects in cancers. However, the molecular mechanism involved hispolon-mediated tumor-suppressing activities observed cervical cancer is poorly characterized. Here, we demonstrated that treatment with hispolon inhibited cell metastasis two lines. In addition, downregulation of lysosomal protease Cathepsin S (CTSS) was critical for suppression tumor both vitro vivo models. Moreover, induced...
Nobiletin, a polymethoxyflavone, has few pharmacological activities, including anti-inflammation and anti-cancer effects. However, its effect on human osteosarcoma progression remains uninvestigated. Therefore, we examined the effectiveness of nobiletin against cellular metastasis underlying mechanisms. up to 100 μM without cytotoxicity, significantly decreased motility, migration invasion as well enzymatic protein levels mRNA expressions matrix metalloproteinase (MMP)-2 MMP-9 in U2OS HOS...
Praeruptorin A (PA) is a pyranocumarin present in the dried root of Peucedanumpraeruptorum Dunn that has anticancer effects against several types cells. However, effect PA on human cervical cancer cells unknown. Our results indicate significantly inhibited cell proliferation, colony formation, migration, invasion, and wound closure HeLa SiHa cells, induced cycle arrest at G0/G1 phase, upregulated Rb, p16, p21 p27 proteins downregulated cyclin D1 S-phase kinase-associated protein 2 (Skp2)...
Oral squamous cell carcinoma (OSCC) is often diagnosed at a late stage and may be malignantly transformed from oral leukoplakia (OL). This study aimed to identify potential plasma microRNAs (miRNAs) for the early detection of cancer. Plasma normal, OL, OSCC patients were evaluated. Small RNA sequencing was used screen differently expressed miRNAs among groups. Next, these validated with individual samples by quantitative real-time polymerase chain reaction (qRT-PCR) assays in training phase...
Human cervical cancer is the fourth most common malignancy among women worldwide, and it expected to result in 460,000 deaths per year by 2040. Moreover, patients with often display drug resistance severe side effects; therefore, development of effective novel chemotherapeutic agents important. In present study, effects metformin, a first‑line therapeutic for type 2 diabetes mellitus, were evaluated cancer. Compared control group, metformin significantly inhibited cell viability migration,...
The inhibitory effect of melatonin on cancer cell dissemination is well established, yet the functional involvement lncRNAs in signaling remains poorly understood. In this study, we identified a melatonin-attenuated lncRNA acting as potential melatonin-regulated oral stimulator (MROS-1). Downregulation MROS-1 by suppressed TPA-induced migration through replenishing protein expression prune homolog 2 (PRUNE2), which functioned tumor suppressor cancer. Melatonin-mediated MROS-1/PRUNE2 and...