Abstract Dysbiosis of oral microbiome may dictate the progression squamous cell carcinoma (OSCC). Yet, composition fluctuates by saliva and distinct sites cavity is affected risky behaviors (smoking, drinking betel quid chewing) individuals’ health condition. To characterize disturbances in microbial population mainly due to tumorigenicity, we profiled bacteria within surface OSCC lesion its contralateral normal tissue from discovery (n = 74) validation 42) cohorts male patients with cancers...

The association between migraine and transient global amnesia (TGA) is not determined. Only two clinic-based studies showed that TGA patients had a higher frequency of history. Our population-based study aimed to investigate whether were associated with risk developing TGA.Patients aged ≥18 years identified from the Taiwan National Health Insurance Research Database 2005 2009. Each patient was randomly matched one subject without or other headache disorders based on age, sex cardiovascular...

Background Oral submucous fibrosis ( OSF ) is one of the well‐recognized oral potentially malignant disorders. In this study, we investigated transformation in a Taiwanese population. Methods A retrospective cohort study was analyzed from Taiwan's National Health Insurance Research Database. comparison randomly frequency‐matched with according to age, sex, and index year. leukoplakia OL further stratified evaluate for possible synergistic effects ‐associated transformation. Results cohort,...

Oral squamous cell carcinoma (OSCC) is a leading cause of cancer-related deaths worldwide. It has very poor prognosis with over 5-year survival rate only 50%. Thus, it important to identify effective therapeutic interventions against oral cancer. Apoptosis and autophagy have reported genetically regulated in physiology diseases, which close relationship. Many natural compound study objects anticancer effect been studied between apoptosis The present was designed evaluate the erianin on human...

L48H37 is a synthetic curcumin analog that has anticancer potentials. Here, we further explored the effect of on oral cancer cells and its mechanistic acts. Cell cycle distribution was assessed using flow cytometric analysis. Apoptosis elucidated by staining with PI/Annexin V activation caspase cascade. Cellular signaling apoptotic protein profiling, Western blotting, specific inhibitors. Our findings showed significantly reduced cell viability SCC-9 HSC-3 cells, resulting in sub-G1 phase...

Controversy exists regarding glucocorticoids therapy and the risk of peptic ulcer bleeding (PUB).The present study was undertaken to determine whether short-term use is associated with occurrence bleeding.The records adult patients hospitalised for newly diagnosed from 2000 2012 were retrieved Taiwan National Health Insurance Research Database, a nationwide population-based registry system. The association between systemic usage determined conditional logistic regression model comparing...

Probiotics can stabilize gut flora, regulate intestinal immunity and protect the host from enteric diseases; however, their roles in oral health have received little attention compared to health. Nowadays, prevalence of sugar-sweetened foods abuse antibiotics contribute towards dysbiosis microbiota drug resistance development pathogens, resulting various intractable diseases. We screened antibacterial activities viable heat-killed probiotic strains against pathogens Streptococcus mutans,...

Aging | doi:10.18632/aging.203923. Chiao-Wen Lin, Yi-Tzu Chen, Hsieh-Hsun Ho, Yi-Wei Kuo, Wen-Yang Jui-Fen Jia-Hung Cheng-Ruei Liu, Chi-Huei Yao-Tsung Yeh, Ching-Wei Yu-Fen Huang, Chen-Hung Hsu, Pei-Shan Hsieh, Shun-Fa Yang

Abstract Oral squamous cell carcinoma (OSCC) has a high recurrence rate and poor prognosis. Hispolon, polyphenolic compound with antiviral, antioxidant, anticancer activities, is potential chemotherapy agent. However, few studies have investigated the anti‐cancer mechanism of hispolon in oral cancer. This present study used viability assay, clonogenic fluorescent nuclear staining, flow cytometry assay to analyse apoptosis‐inducing effects OSCC cells. After treatment, apoptotic initiators,...

Oral squamous cell carcinoma (OSCC) is a common malignant disease associated with high mortality rate and heterogeneous aetiology. Cyclin dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1), long noncoding that has been shown to act as scaffold, sponge, or signal hub promote carcinogenesis. Here, we attempted assess the effect of CDKN2B-AS1 single-nucleotide polymorphisms (SNPs) on susceptibility OSCC. Five SNPs, including rs564398, rs1333048, rs1537373, rs2151280 rs8181047, were...

Impaired cerebral microcirculation after subarachnoid hemorrhage (SAH) has been shown to be related delayed ischemic neurological deficits (DIND). We previously demonstrated the involvement of receptor for advanced glycation end products (RAGE) in pathogenesis SAH neuronal death. In present study, we aimed investigate therapeutic effects a recombinant soluble form RAGE (sRAGE) on impairment following SAH. Intrathecal injection autologous blood rats, mixed primary astrocyte and microglia...

The present investigation examined whether an association exists between betel quid chewing and signs of periodontal disease determined the prevalence Actinobacillus actinomycetemcomitans Porphyromonas gingivalis by polymerase chain reaction. status 34 chewers 32 non‐betel were compared. A significantly higher bleeding on probing was found in than non‐chewers among subjects with plaque level, greater gingival inflammation, deeper depth or attachment loss. Also, results suggested that may...

Among the microarray data analysis clustering methods, K-means and hierarchical are researchers' favorable tools today. However, each of these traditional methods has its limitations. In this study, we introduce a new method, regulating divisive or agglomerative approach. The firstly employs K-means' algorithm in cluster to determine K while operating then it on technique shorten merging clusters time generating tree-like dendrogram. We apply method two original datasets. result indicates is...

Our purpose was to determine the association of cataract surgery with subsequent development dementia in older adults newly diagnosed cataract.By using data from Taiwan National Health Insurance Research Database (NHIRD), a population-based cohort study including 491 226 subjects aged 70 or first-time diagnosis coded 2000 2009 conducted. After matching patients receiving without for age, sex, index date, Charlson Comorbidity Index score, interval between first coding and hypertension...

Glabridin, a flavonoid extracted from licorice (Glycyrrhiza glabra), possesses various biological properties, including anticancer activities. However, the effect of glabridin on oral cancer cell apoptosis and underlying molecular mechanisms has not been elucidated. In this study, we demonstrated that treatment significantly inhibits proliferation in human SCC-9 SAS lines. Flow cytometric assays induced several features apoptosis, such as sub-G1 phase increase phosphatidylserine...

Probiotics participate in regulating oral microbiota and reducing the prevalence of diseases; however, clinical research on probiotics is insufficient. Therefore, this study, we performed vitro screening potential protective probiotic strains then evaluated efficacy selected maintaining health.Fifty healthy individuals were recruited randomly assigned into placebo group group, which included three probiotics, Lactobacillus salivarius subs. salicinius AP-32, paracasei ET-66, plantarum LPL28....

Aneurysmal subarachnoid hemorrhage (SAH) can cause severe neurological deficits and high mortality. Early brain edema following SAH contributes to the initiation of microcirculation impairment may further lead delayed ischemic neurologic deficit (DIND). This study aimed investigate whether dental pulp stem cell conditioned medium (DPSC-CM) ameliorates SAH-induced underlying mechanisms. was induced via intrathecal injection fresh autologous blood in Wistar male adult rat. DPSC-CM or + insulin...

Cytotoxic effects of resin liquids three in situ relining dental polymers, Alike, Kooliner, and Tokuso Rebase, their major components, methyl methacrylate (MMA), isobutyl (IBMA), 1,6-hexanediol dimethacrylate (1,6-HDMA) were investigated. The concentrations monomers these determined by high-performance liquid chromatography. Cellular viability human gingival fibroblasts (GF) periodontal ligament (PDL) cells evaluated the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyltetrazolium bromide assay....

Oral leukoplakia (OL) is one of the clinically diagnosed oral potentially malignant disorders (OPMDs) with an increased risk cancer development. In this study, we investigated transformation OL in Taiwanese population.A retrospective cohort study was analyzed from Taiwan's National Health Insurance Research Database. A comparison randomly frequency-matched according to age, sex, and index year. submucous fibrosis (OSF) lichen planus (OLP) were further stratified evaluate possible synergistic...

Oral squamous cell carcinoma (OSCC) is a prevalent and lethal malignancy with diverse etiology.LINC00312 long intergenic non-coding RNA that functions as signal hub to regulate the progression treatment of head neck cancer.The aim this study was evaluate effect LINC00312 single nucleotide polymorphisms (SNPs) on development oral cancer.Two SNPs, namely rs12497104 rs164966, were investigated among 469 male patients cancer buccal mucosa 1194 gender-and age-matched controls.No significant...

Inadequate diagnosis, treatment, and palliative care provided in the emergency department could let patients revisit shortly after being seen. The aim of this study was to evaluate dental revisits by using Taiwanese National Health Insurance Research Database (NHIRD). Dental dataset from NHIRD used analyze demographic characteristics population 1999 2012. In addition, conditions were also identified based on International Classification Diseases, Ninth Revision (ICD-9). Total 169,437...

Oral cancer is the most common oral malignant tumor in Taiwan. Although there exist several methods for treatment, still has a poor prognosis and high recurrence. FLLL32, synthetic analog of curcumin with antitumor activity, currently known to induce melanoma apoptosis inhibit growth various cancers. However, few studies have examined mechanisms FLLL32 cancer. In this study, we explore whether induces We determined that can cell viability Next, analyzed effect on cycle cells observed...

Abstract A disintegrin and metalloproteinase domain‐containing protein 10 (ADAM‐10) involves in the tumour progression, but impacts of single‐nucleotide polymorphism (SNP) ADAM‐10 on oral squamous cell carcinoma (OSCC) remain unclear. The aim this study was to investigate influence SNP clinical features OSCC male Taiwanese. Five loci SNPs including rs653765 (C/T), rs2305421 (A/G), rs514049 (A/C), rs383902 (T/C) rs2054096 (A/T) were genotyped by TaqMan allelic discrimination 1138 patients...

Magnolol is a natural compound extracted from Chinese herbal medicine and can induce apoptosis in numerous types of cancer cells. However, the molecular mechanisms magnolol oral are still unclear. In this study, we investigated anti-cancer effects underlying human cell lines. Our results exhibited that inhibited proliferation via inducing sub-G1 phase HSC-3 SCC-9 The array Western blot assay showed increased expression cleaved caspase-3 proteins heme oxygenase-1 (HO-1). Moreover, proved...