Oral submucous fibrosis (OSF) has been regarded as a precancerous condition. Research examining the prevalence of OSF could be first step in preventing or reducing malignant transformation. In this study, we probed nationwide registered database to assess prevalence, gender distribution, age, income, and urbanization status patients Taiwan.A retrospective study was conducted analyze compiled by National Health Insurance provided Ministry Welfare, Taiwan. We identified dental visit diagnosed...

Background Oral submucous fibrosis ( OSF ) is one of the well‐recognized oral potentially malignant disorders. In this study, we investigated transformation in a Taiwanese population. Methods A retrospective cohort study was analyzed from Taiwan's National Health Insurance Research Database. comparison randomly frequency‐matched with according to age, sex, and index year. leukoplakia OL further stratified evaluate for possible synergistic effects ‐associated transformation. Results cohort,...

Pneumonia is a common respiratory infectious disease that involves the inflammation of pulmonary parenchyma. Periodontal widespread and correlated with pneumonia. However, relationship between periodontal treatment clinical outcomes in patients pneumonia has remained undetermined. The aim this study was to investigate association risk events Taiwanese population. A nationwide population-based cohort conducted using data from National Health Insurance Research Database (NHIRD). total 49,400...

Periodontitis is one of the most prevalent oral diseases. In this study, we probed nationwide registered database to assess time trends prevalence periodontitis in Taiwan.A retrospective study was conducted analyze compiled by National Health Insurance provided Department Health, Taiwan, from 1997 December 2013.We found that significantly increased 11.5% 19.59% 2013 (P for trend < .0001). The mean age ± standard deviation with 54.46 14.47 and 45.51 16.58 years old, respectively. proportion...

The disparate or irregular dental care was associated with acute clinical problems that may lead to seeking for emergency visits. aim of this study determine the time trends, demographics, and conditions (ED) visits in Taiwan.This cross-sectional conducted analyze insurance reimbursement services National Health Insurance Research Database. demographic characteristics age-period effects ED were estimated by multivariate Poisson regression. In addition, top causes evaluated stratified...

Periodontitis and psoriatic disease, including psoriasis (PS) arthritis (PsA), share the common risk factors co-morbidities. However, of periodontitis in patients with disease still needs further investigation. This study was a nationwide population-based retrospective cohort assessing from exposure.Patients newly diagnosed 2003 to 2012 were identified Taiwanese National Health Insurance Research Database. The 1:4 ratio propensity score matched controls selected no participations. subsequent...

Cigarette smoking is an important risk factor in the pathogenesis of periodontal disease. However, little known about effect nicotine, major component cigarette smoke, on cementoblasts. The aim this study was to investigate pathological effects nicotine murine immortalized cementoblast cell line (OCCM.30). Cell viability judged by using Alamar Blue reduction assay. migration evaluated transwell and wound-healing assays. protein concentrations interleukin-6 (IL-6) tumor necrosis alpha (TNF-α)...

Previous studies have suggested that peptic ulcer disease (PUD) including stomach and duodenal ulcers might be associated with periodontitis (PD); however, no clear conclusions been reached thus far. In this retrospective case-control study, we aimed to investigate the association between PUD PD by using a large population-based dataset in Taiwan. A case control study was conducted Longitudinal Health Insurance Database 2010 (LHID2010) derived from National Research database (NHIRD) Taiwan...

Oral leukoplakia (OL) is one of the clinically diagnosed oral potentially malignant disorders (OPMDs) with an increased risk cancer development. In this study, we investigated transformation OL in Taiwanese population.A retrospective cohort study was analyzed from Taiwan's National Health Insurance Research Database. A comparison randomly frequency-matched according to age, sex, and index year. submucous fibrosis (OSF) lichen planus (OLP) were further stratified evaluate possible synergistic...

Inadequate diagnosis, treatment, and palliative care provided in the emergency department could let patients revisit shortly after being seen. The aim of this study was to evaluate dental revisits by using Taiwanese National Health Insurance Research Database (NHIRD). Dental dataset from NHIRD used analyze demographic characteristics population 1999 2012. In addition, conditions were also identified based on International Classification Diseases, Ninth Revision (ICD-9). Total 169,437...

Temporomandibular disorder (TMD) is defined as various clinical signs and symptoms involving the masticatory muscles, temporomandibular joint associated structures. The aim of this study was to investigate prevalence diagnosed TMD in Taiwan using a National Health Insurance Research Database from 2004 2013.A retrospective conducted analyze registered database compiled by 2013. diagnosis TMDs identified accordance with International Classification Disease, Ninth revision (ICD-9-CM 524.6)....

Abstract The role of B cells in the development CD4 + regulatory T has been emphasized recently. Our previous studies have demonstrated that antigen-presenting splenic converted naïve CD25 − into Foxp3 without additional cytokines or chemicals with activity and referred to as Treg-of-B cells. present study further showed increased IL-10-producing population, expression c-Maf, inducible T-cell co-stimulator (ICOS) well cytotoxic T-lymphocyte-associated protein 4 (CTLA4) after repeated...

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women reproductive age. Both hormonal and inflammatory influences are assumed to affect periodontal tissues. Previous studies have shown that PCOS patients could higher prevalence gingival inflammation. However, relationship between chronic periodontitis (CP) not clear. Materials Methods: In this study, we evaluated risk from CP exposure in a nationwide population-based retrospective cohort study...

Gingival overgrowth occurs as a side effect of systemic medication with immunosuppressant cyclosporine A (CsA). Slug, master regulator epithelial–mesenchymal transition, is dramatically upregulated in variety fibrotic diseases. The aim this study to investigate the role transition marker Slug pathogenesis CsA-induced gingival overgrowth. Clinically healthy gingiva and specimens were analyzed by immunohistochemistry. CsA on normal human fibroblasts (HGFs) was used elucidate whether expression...

Previous studies have suggested that obesity might be associated with chronic periodontitis (CP); however, no clear conclusions been reached so far. In this retrospective cohort study, we aimed to investigate the association between and CP by using a large population-based dataset in Taiwan.A study was conducted Longitudinal Health Insurance Database 2010 (LHID2010) derived from National Research database Taiwan, 2000 2013. Obesity non-obesity groups were matched sex, age, urbanization...

Many reports have mentioned the association between chronic periodontitis (CP) and primary Sjögren syndrome (pSS). However, no cohort study has been performed for risk of pSS in patients with CP. In this study, we evaluated from CP exposure a nationwide population-based Taiwan. We studied claims data Taiwanese population 2001 to 2012. identified 76,765 National Health Insurance Database also selected controls that were randomly frequency matched by age, sex, index year general population....

Oral lichen planus (OLP) is a common chronic inflammatory disease characterized by T cell-mediated immune response against epithelial cells. The epidemiological survey of OLP in Taiwanese population was scarce. In this study, we investigated the time trend prevalence stratified gender, age, urbanization, and income based on National Health Insurance Research Database (NHIRD). We studied claims data from NHIRD 1996 to 2013. Patients with diagnosis International Classification Diseases, Ninth...

Sialolithiasis, the so-called salivary gland stone, is a condition forming calculi within or ducts. Little known about epidemiological survey of sialolithiasis in Taiwanese population. In this study, we conducted an age-period-cohort (APC) analysis evaluating prevalence sialolithiasis.A retrospective study was to analyze registered database compiled by National Health Insurance Research Database from 1996 2013. The APC performed investigate effects age, diagnosis period, and birth cohort...

Multiple sclerosis (MS) is an inflammatory neurological disease characterized by autoimmune-mediated demyelination of the central nervous system. Genetic and environmental factors may contribute to development MS. This has not been confirmed yet. Dental amalgam long controversial in MS due its mercury content but toxicological implications mercury-containing fillings (AMF) for remain be elucidated. We conducted a case-control study investigate association between AMF risk from Taiwanese...

Fibroblast growth factor (FGF)-2 is known as a signaling molecule that induces tissue regeneration. Little about the effect of FGF-2 on cementoblasts for periodontal and periapical The aim this study was to investigate effects murine immortalized cementoblast cell line (OCCM.30).Cell proliferation judged by using alamar blue reduction assay. Flow cytometry analysis used evaluate Stro-1 positive cells expression with or without FGF-2. Western blot phosphorylated serine-threonine kinase Akt...

Trigeminocardiac reflex (TCR) is a clinical phenomenon that manifests as s sudden onset of hemodynamic perturbations. TCR has been reported in cranio-maxillofacial surgery resulting severe medical risks. Monitoring the changes during can provide important information to ensure continuous evaluation patient's physical conditions. This prospective observational study was conducted determine alterations related possibly occurrence patients dental implant surgery.One hundred and thirty-five (69...