A5029283145- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Estrogen and related hormone effects
- Metastasis and carcinoma case studies
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Cancer and Skin Lesions
- Epigenetics and DNA Methylation
- Monoclonal and Polyclonal Antibodies Research
- RNA modifications and cancer
- Gastrointestinal disorders and treatments
- AI in cancer detection
- Viral-associated cancers and disorders
- CNS Lymphoma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Cancer-related Molecular Pathways
- Breast Implant and Reconstruction
- Ubiquitin and proteasome pathways
- Medical Imaging and Pathology Studies
- Bone and Dental Protein Studies
- Liver Disease Diagnosis and Treatment
- Cancer Treatment and Pharmacology
National Taiwan University Hospital
2015-2024
National Taiwan University
2013-2024
National Chung Hsing University
2011
National Taipei University
2011
The University of Texas MD Anderson Cancer Center
2004-2011
China Medical University Hospital
2011
China Medical University
2011
China Medical University
2011
Asia University
2011
Changhua Christian Hospital
2010
Abstract Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible assessment. Previously developed standardized scoring guidelines have been widely embraced by the research communities. We evaluated sources of variability sTIL assessment pathologists three previous ring studies. identify common challenges evaluate impact...
Abstract Cytotoxic T lymphocytes (Tc) play a central role in cellular immunity against cancers. The cytotoxic potential of freshly isolated tumor-infiltrating (TILs) is usually not expressed. This suggests the possible existence as yet unspecified and perhaps complex immunosuppressive factors or cytokines that affect anti-tumor capacity these TILs tumor milieu. In present study, we demonstrated for first time derived from human cervical cancer tissue consist mainly Th2/Tc2 phenotypes. vitro...
Aberrant regulation of rRNA synthesis and translation control can facilitate tumorigenesis. The ErbB2 growth factor receptor is overexpressed in many human tumors has been detected the nucleus, but role nuclear obscure. In this study, we defined a novel function enhancing gene transcription by RNA polymerase-I (RNA Pol I). Nuclear physically associates with β-actin I, coinciding active I sites nucleoli. interference-mediated knockdown reduced pre-rRNA protein synthesis. contrast, wild-type...
Breast cancer is the leading cause of death for women globally. In clinical practice, pathologists visually scan over enormous amounts gigapixel microscopic tissue slide images, which a tedious and challenging task. breast diagnosis, micro-metastases especially isolated tumor cells are extremely difficult to detect easily neglected because tiny metastatic foci might be missed in visual examinations by medical doctors. However, literature poorly explores detection cells, could recognized as...
Abstract Metaplastic carcinoma of the breast (MCB) is characterized by biphasic presence both a carcinomatous component (CC) and heterogeneous sarcomatous components (HSCs). Although an epithelial or myoepithelial origin HSCs has been suggested, molecular evidence for common CC limited mechanism underlying metaplastic change unknown. The present study investigated frequency nature p53 expression mutation in 11 three monophasic MCBs immunohistochemistry either needle‐assisted laser‐capture...
Wang C‐C, Liau J‐Y, Lu Y‐S, Chen J‐W, Yao Y‐T & Lien H‐C (2012) Histopathology 61, 78–87 Differential expression of moesin in breast cancers and its implication epithelial–mesenchymal transition Aims: Moesin belongs to the ERM (ezrin, radixin moesin) family. Recent in‐vitro studies have shown possible involvement (EMT), but correlating in‐vivo evidence is lacking. Methods results: To study biological significance moesin, we used immunohistochemistry investigate in‐situ profiles 322...
Although breast phyllodes tumors are rare, there is no effective therapy other than surgery. Little known about their tumor biology. A malignant contains heterologous stromal elements, and can transform into rhabdomyosarcoma, liposarcoma osteosarcoma. These versatile properties prompted us to explore possible relationship mesenchymal stem cells (MSCs) search for the presence of cancer (CSCs) in tumors. Paraffin sections were examined various markers by immunohistochemical staining....
G-protein-coupled receptor 30 (GPR30) has been reported to be a novel estrogen (ERa) in vitro. Therefore, the interactions among GPR30, ERa, progesterone (PR) and human epidermal growth factor receptor-2 (HER-2/neu), their prognostic utilities infiltrating ductal carcinoma (IDC) of breast were evaluated. Messenger RNA (mRNA) levels PR HER-2/neu tumor samples 118 Taiwanese IDC patients 27 non-tumor mammary tissues measured via quantitative polymerase chain reaction analyses. The correlations...
Abstract: The purpose of this study was to characterize the immunohistochemical distribution secreted protein acidic and rich in cystein (SPARC) benign malignant breast tumors different histologic types define its association with outcome invasive ductal carcinoma (IDC) patients. A total 286 samples lesions between 1994 2005 were retrieved from National Taiwan University Hospital. Up 11 years clinical follow-up data available for 185 patients IDC. Immunohistochemistry staining SPARC...
// Sung-Hsin Kuo 1, 5, 6, 7 , Shi-Yi Yang 8 San-Lin You 9, 10 Huang-Chun Lien 2 Ching-Hung Lin 6 Po-Han 3 Chiun-Sheng Huang 4 1 Department of Oncology, National Taiwan University Hospital and College Medicine, Taipei, Pathology, Medical Genetics, Surgery, 5 Graduate Institute Cancer Research Center, Epidemiology, Public Health, University, 9 School Fu-Jen Catholic New Big Data Correspondence to: Huang, email: huangcs@ntu.edu.tw Keywords: genetic polymorphism, GWAS, breast cancer, prognostic...
Aims Hyaluronan synthase 2 (HAS2) is an enzyme in hyaluronan synthesis. Several studies have demonstrated that HAS2 plays a critical role tumour progression breast cancer cells. The in-situ expression patterns of remain unclear, and the aim this study was to determine these order elucidate cancer. Methods results We examined using immunohistochemistry 244 carcinomas various subtypes. found 30.6% invasive ductal (IDCs); IDCs, correlated significantly with triple-negative phenotype basal-like...
In addition to contraction, myoepithelia have diverse paracrine effects, including a tumor suppression effect. However, certain myoepithelial markers been shown contribute progression. Transforming growth factor-β (TGF-β) is involved in the transdifferentiation of fibroblasts contractile myofibroblasts. We investigated whether TGF-β can upregulate potential markers, which may functional and clinicopathological significance breast cancer. found that induced SPOCK1 expression MCF10A, MCF12A,...