A5045276882- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Cancer Risks and Factors
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- AI in cancer detection
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Diet and metabolism studies
- Cancer-related gene regulation
- Cancer survivorship and care
- Estrogen and related hormone effects
- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Scheduling and Optimization Algorithms
- Ultrasound Imaging and Elastography
- Cancer Treatment and Pharmacology
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related Molecular Pathways
- Cancer-related cognitive impairment studies
- Adipose Tissue and Metabolism
- Genetic factors in colorectal cancer
- Cancer, Lipids, and Metabolism
National Taiwan University Hospital
2015-2024
National Taiwan University
2008-2024
National Yang Ming Chiao Tung University
2016-2023
University of Nebraska Medical Center
2022
Walden University
2016-2020
China Medical University
2017
China Medical University Hospital
2017
Institute of Molecular Biology, Academia Sinica
2016
National Formosa University
2006-2011
National University of Formosa
2011
The early onset breast cancer patients (age ≤ 40) often display higher incidence of axillary lymph node metastasis, and poorer five-year survival than the late-onset patients. To identify genes molecules associated with poor prognosis cancer, we examined gene expression profiles from paired normal/tumor tissues, coupled Gene Ontology public data base analysis. Our showed that GAS7b was lower in as compared to elder We found GAS7 CYFIP1 WAVE2 complex suppress metastasis via blocking Rac1...
Heterogeneity of cancer stem/progenitor cells that give rise to different forms has been well demonstrated for leukemia. However, this fundamental concept yet be established solid tumors including breast cancer. In communication, we analyzed tumor stem cell markers in human lines and primary specimens using flow cytometry. The properties marker expressing-cell populations were further assessed by vitro soft agar colony formation assay the ability form NOD/SCID mice. We found expression...
It has been well documented that microenvironment consisting of stroma affects breast cancer progression. However, the mechanisms by which cells and fibroblasts, major cell type in stroma, interact with each other during tumor development remains to be elucidated. Here, we show human cancer-associated fibroblasts (CAFs) had higher activity enhancing tumorigenecity compared normal tissue-associated (NAFs) isolated from same patients. The expression level hepatocyte growth factor (HGF) these...
The circadian clock gene Period2 (PER2) has been suggested to be a tumor suppressor. However, detailed mechanistic evidence not provided support this hypothesis. We found that loss of PER2 enhanced invasion and activated expression epithelial-mesenchymal transition (EMT) genes including TWIST1, SLUG, SNAIL. This finding was corroborated by clinical observation down-regulation associated with poor prognosis in breast cancer patients. further demonstrated served as transcriptional corepressor,...
Metastasis is the predominant cause of death in breast cancer patients. Several lines evidence have shown that microRNAs (miRs) can an important role metastasis. Using isogenic pairs low and high metastatic derived from a human line, we identified miR-149 to be suppressor cell invasion We also GIT1 (G-protein-coupled receptor kinase-interacting protein 1) as direct target miR-149. Knockdown reduced migration/invasion metastasis highly invasive cells. Re-expression significantly rescued...
Although metabolic reprogramming is recognized as a hallmark of tumorigenesis and progression, little known about enzymes oncometabolites that regulate breast cancer metastasis, very few molecules have been identified potential therapeutic targets. In this study, the transketolase (TKT) expression correlated with tumor size in 4T1/BALB/c syngeneic model. addition, TKT was higher lymph node metastases compared primary or normal tissues patients, high levels were associated poor survival....
MicroRNAs (miRNAs) are short, non-coding RNA molecules that play critical roles in human malignancy. However, the regulatory characteristics of miRNAs triple-negative breast cancer, a phenotype cancer does not express genes for estrogen receptor, progesterone and epidermal growth factor receptor 2, still poorly understood. In this study, miRNA expression profiles 24 cancers 14 adjacent normal tissues were analyzed using deep sequencing technology. Expression levels reads normalized with...
Abstract Adipocytes are the most abundant stromal partners in breast tissue. However, crosstalk between cancer cells and adipocytes has been given less attention compared to cancer-associated fibroblasts. Here we find, through systematic screening, that primary mammary gland-derived (MGDAs) promote growth of express monocarboxylate transporter 2 (MCT2) both vitro vivo . We show β-hydroxybutyrate is secreted by MGDAs required enhance malignancy Consistently, sufficient tumorigenesis a mouse...
// Po-Han Lin 1, 2 , Wen-Hung Kuo 3 Ai-Chu Huang Yen-Shen Lu 4 Ching-Hung Sung-Hsin Ming-Yang Wang Chun-Yu Liu 6 Fiona Tsui-Fen Cheng 7 Ming-Hsin Yeh 8 Huei-Ying Li Yu-Hsuan Yang Yu-Hua Hsu Sheng-Chih Fan Long-Yuan 9 Sung-Liang Yu 10 King-Jen Chang 11 Pei-Lung Chen Yen-Hsuan Ni 2, 5 Chiun-Sheng 1 Graduate Institute of Clinical Medical Science, China University, Taichung, Taiwan Department Genetics, National University Hospital, Taipei, Surgery, Oncology, Pediatrics, Division Taipei Veterans...
Breast cancer (BC) is a common in women worldwide; however, the incidence of BC increasing younger women, possibly associated with environment. Perfluoroalkyl substances (PFAS) are one endocrine disruptors that accumulate environment and impact human health. This study aimed to investigate whether PFAS associated. We enrolled 120 BCE patients 119 controls at National Taiwan University Hospital (NTUH) also collected bio-specimen questionnaire from 2013 2015. All subjects' plasma levels were...
Abstract Background: In the past two decades, incidence of breast cancer in young Taiwanese females has been rapidly increasing, approaching risk level western countries. As a first step to investigate possible etiology, we examined molecular subtypes female Taiwan. Methods: This study included 1,028 consecutive patients with diagnosed National Taiwan University Hospital between 2004 and 2006. Estrogen receptor (ER), progesterone (PR), human epidermal growth factor receptor-2, cytokeratin...
Targeting of tumor tissues is one the most powerful approaches to accelerate efficiency anticancer treatments. The investigation effective targets, including proteins specifically and abundantly expressed in abnormal regions, has been important research topics cancer therapy. In this study, we performed a proteomic analysis on human breast carcinoma investigate tumor-specific protein expression carcinoma. Our study showed that ATP synthase was up-regulated present plasma membrane cells....
Background Triple-negative breast cancer is a subtype of with aggressive tumor behavior and distinct disease etiology. Due to the lack an effective targeted medicine, treatment options for triple-negative are few recurrence rates high. Although various multi-gene prognostic markers have been proposed prediction outcome, most them were proven clinically useful only estrogen receptor-positive cancers. Reliable identification patients favorable prognosis not yet possible. Methodology/Principal...
Abstract Constructing ultrasound statistical parametric images by using a sliding window is widely adopted strategy for characterizing tissues. Deficiency in spatial resolution, the appearance of boundary artifacts, and prerequisite data distribution limit practicability imaging. In this study, small-window entropy imaging was proposed to overcome above problems. Simulations measurements phantoms were executed acquire backscattered radiofrequency (RF) signals, which processed explore...
<h3>Importance</h3> Different screening strategies for breast cancer are available but have not been researched in quantitative detail. <h3>Objective</h3> To assess the benefits and harms of risk-based universal mammography comparison with annual clinical examination (CBE). <h3>Design</h3> Population-based cohort study comparing incidences stage II+ disease death from across 3 strategies, adjustment a propensity score participation based on risk factors overdetection between January 1999...
Abstract Background The clinicopathological features and prognosis of breast cancer in Asia are different from those the Western countries. Tumor-infiltrating immune cells can influence outcome patients with cancer, but they have not been systemically evaluated Asian cancer. Methods We compared score, composition, prognostic impact infiltrating between by analyzing gene expression profiles eight Gene Expression Omnibus data sets Cancer Genome Atlas set. Estimation Stromal Immune Cells...
Abstract The objective of this study was to test the reliability and validity Taiwan Chinese version EORTC QLQ‐C30 (version 3) QLQ‐BR23. authors followed guidelines translation pilot testing questionnaires. questionnaires were given 35 breast cancer patients under active treatment 54 follow‐up at National University Hospital from November 2000 October 2001. A retest conducted one two weeks after first interview/form completion for group. intraclass correlation coefficients moderate high in...