A5049975962- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- ATP Synthase and ATPases Research
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- HER2/EGFR in Cancer Research
- Cancer, Hypoxia, and Metabolism
- Protease and Inhibitor Mechanisms
- Photosynthetic Processes and Mechanisms
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- Cell Adhesion Molecules Research
- Mitochondrial Function and Pathology
- Angiogenesis and VEGF in Cancer
- PI3K/AKT/mTOR signaling in cancer
- Lung Cancer Treatments and Mutations
- RNA Research and Splicing
- Lung Cancer Research Studies
- Cancer Research and Treatments
- Mesenchymal stem cell research
- Glycosylation and Glycoproteins Research
- DNA Repair Mechanisms
National Health Research Institutes
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Institute of Cancer Research
2016
Harvard University
1993-2014
Beth Israel Deaconess Medical Center
2008-2014
Peking University
2014
Taoyuan Armed Forces General Hospital
2010
National Yang Ming Chiao Tung University
2010
Chang Gung Memorial Hospital
2010
Tamkang University
2009
The early onset breast cancer patients (age ≤ 40) often display higher incidence of axillary lymph node metastasis, and poorer five-year survival than the late-onset patients. To identify genes molecules associated with poor prognosis cancer, we examined gene expression profiles from paired normal/tumor tissues, coupled Gene Ontology public data base analysis. Our showed that GAS7b was lower in as compared to elder We found GAS7 CYFIP1 WAVE2 complex suppress metastasis via blocking Rac1...
Abstract microRNA (miRNA) dysregulation contributes widely to human cancer but has not been fully assessed in oral cancers. In this study, we conducted a global microarray analysis of miRNA expression 40 pairs betel quid–associated squamous cell carcinoma (OSCC) specimens and their matched nontumorous epithelial counterparts. Eighty-four miRNAs were differentially expressed the OSCC compared with tissue. Among these downregulated miRNAs, 19 found mapped chromosome 14q32.2 cluster region,...
Lon protease is a multifunction protein and operates in quality control stress response pathways mitochondria. Human upregulated under oxidative hypoxic stresses that represent the phenotypes of cancer. However, little literature undertakes comprehensive detailed investigations on tumorigenic role Lon. Overexpression promotes cell proliferation, apoptotic resistance to stresses, transformation. Furthermore, overexpression induces production mitochondrial reactive oxygen species (ROS) result...
Mitochondrial Lon is a chaperone protein whose upregulation increases the production of mitochondrial reactive oxygen species (ROS). However, there lack information in detail on how regulates cancer metastasis through ROS tumor microenvironment (TME). Our results show that elevated promotes epithelial-mesenchymal transition (EMT) via ROS-dependent p38 and NF-κB-signaling. We further identified pyrroline-5-carboxylate reductase 1 (PYCR1) as client Lon, which induces EMT by Lon. inflammatory...
Abstract Purpose: SOX9 is an important transcription factor required for development and has been implicated in several types of cancer. However, never linked to lung cancer date. Here, we show that expression upregulated adenocarcinoma how it associated with cell growth. Experimental Design: Data mining five microarray data sets containing 490 clinical samples, quantitative reverse transcription-PCR validation assay 57 independent immunohistochemistry tissue microarrays 170 cores were used...
Caffeic acid phenethyl ester (CAPE) treatment suppressed proliferation, colony formation, and cell cycle progression in PC-3 human prostate cancer cells. CAPE decreased protein expression of cyclin D1, E, SKP2, c-Myc, Akt1, Akt2, Akt3, total Akt, mTOR, Bcl-2, Rb, as well phosphorylation ERK1/2, GSK3α, GSK3β, PDK1; but increased KLF6 p21Cip1. Microarray analysis indicated that pathways involved cellular movement, death, were affected by CAPE. Co-treatment with chemotherapeutic drugs...
// Hui-Ping Lin 1, * , Ching-Yu 2, Chieh Huo 3, Ping-Hsuan Hsiao 4, Liang-Cheng Su 2 Shih Sheng Jiang 1 Tzu-Min Chan 5, 6 Chung-Ho Chang Li-Tzong Chen Hsing-Jien Kung 7 Horng-Dar Wang 4 Chih-Pin Chuu 8, 9, 10, 11 National Institute of Cancer Research, Health Research Institutes, Miaoli, Taiwan, ROC Cellular and System Medicine, 3 Department Life Sciences, Central University, Taoyuan, Biotechnology, Tsing Hua Hsinchu City, 5 Medical Education China University Beigan Hospital, Yunlin,...
Exogenous arginine is required for growth in some argininosuccinate synthetase (ASS)-deficient cancers. Arginine deiminase (ADI) inhibits various ASS-deficient cancers by depleting arginine. The efficacy of pegylated ADI (ADI-PEG20) relapsed/refractory/poor-risk acute myeloid leukemia (AML) was evaluated 43 patients a prospective, phase II trial (NCT01910012 (10/07/2013), https://clinicaltrials.gov/ct2/show/NCT01910012?term = ADI-PEG20&rank 12 ). Despite almost all pre-treatment tumor...
Alterations of histone methylation dynamically regulated by methyltransferases and demethylases are frequently found in human cancers. Here, we showed that expression lysine demethylase 2A (KDM2A) is markedly increased breast cancer its overexpression associated with tumor progression poor prognosis. Knockdown KDM2A cells reduced proliferation but not viability. Gene set enrichment analysis revealed inhibition down-regulates angiogenic genes concurrent reduction Jagged1 (JAG1), NOTCH1 HEY1...
Abstract Cell differentiation within stem cell lineages can check proliferative potential, but nodal pathways that limit tumor growth are obscure. Here, we report lung cancer populations generate phenotypic and oncogenic plasticity via a switch between programs controlled by SOX2 SOX9, thus altering invasive capabilities. In cells, bound the EPCAM promoter to induce EpCAM–p21Cip1–cyclin A2 signaling, encouraging proliferation as well barrier properties. contrast, SOX9 SLUG SLUG-mediated...
Abstract Multilineage tissue-source mesenchymal stem cells (MSCs) possess strong immunomodulatory properties and are excellent therapeutic agents, but require constant isolation from donors to combat replicative senescence. The differentiation of human induced pluripotent (iPSCs) into MSCs offers a renewable source MSCs; however, reports on their capacity have been discrepant. Using differentiated iPSCs reprogrammed using diverse cell types protocols, in comparison embryonic (ESC)-MSCs bone...
Abstract Mitochondrial Lon is a multi-function matrix protease with chaperone activity. However, little literature has been undertaken into detailed investigations on how regulates apoptosis through its Accumulating evidences indicate that various stresses induce transportation of p53 to mitochondria and activate in transcription-independent manner. Here we found increased interacts mitochondrial restrains the induced by under oxidative stress rescuing loss membrane potential (Δψm) release...
Cell-cell adhesion is essential for many immunological functions and believed to be important in the regulation of hematopoiesis. Adhesive interactions between human endothelial cells megakaryocytes were characterized vitro using CMK megakaryocytic cell line as well marrow megakaryocytes. Although there was no unactivated umbilical vein (HUVEC) megakaryocytes, treatment HUVEC with inflammatory cytokines such IL-1 beta, tumor necrosis factor alpha, INF-gamma, or phorbol ester myristate...
Areca nut is the most widely used psychoactive substance and an important environmental risk factor for development of oral premalignant lesions cancer. Arecoline, major alkaloid areca nut, has been known to cause cytotoxicity genotoxicity in mammalian cells vivo vitro even contributes carcinogenicity. However, susceptible genes accounting arecoline-induced damage normal human are still lacking, which possibly involves initial molecular via alternation gene expression level on biological...
New potential sources of stem cells for clinical application include bone marrow mesenchymal (BMMSCs), human embryonic (hESCs), and induced pluripotent (iPS). However, each source is not without its own concerns. While research continues in an effort to overcome these problems, the generation progenitors from existing hESC lines may circumvent many issues. We report here a simple efficient method generating hESC-derived (EMPs) transcriptome profiling using concise, custom-designed,...
The majority of prostate cancer (PCa) patient receiving androgen ablation therapy eventually develop castration-resistant (CRPC). We previously reported that treatment suppresses Skp2 and c-Myc through receptor (AR) induced G1 cell cycle arrest in androgen-independent LNCaP 104-R2 cells, a late stage CRPC line model. However, the mechanism androgenic regulation cells was not fully understood. In this study, we investigated two AR-positive models, 104-R1 PC-3AR Cells. former one is an early...
Abstract CISD2 is a redox-sensitive gene critical for normal development and mitochondrial integrity. was known to have aberrant expression in several types of human cancers. However, its relation with lung cancer still not clear. In this study we found mRNA significantly upregulated adenocarcinoma (ADC) samples, compared their adjacent counterparts, correlated tumor stage, grade, prognosis based on analysis clinical specimens-derived data public domain our validation assay. Cell assay...
Cancer-associated fibroblast (CAF) recruitment and activation within the tumor microenvironment (TME) are increasingly acknowledged as drivers of oral squamous cell carcinoma (OSCC) growth metastasis. Therefore, mechanisms underlying crosstalk warrant further investigation. We discovered that ectopic interferon-stimulated gene 15 (ISG15) expression, which is a promising novel oncoprotein biomarker elevated in variety cancers, enhanced OSCC collagen α-smooth muscle actin (α-SMA) expression...
PCK2, which encodes mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M), is upregulated in various cancers. We demonstrated high expression of PEPCK-M approximately half triple-negative breast cancers (TNBCs) previously. TNBC associated with an aggressive phenotype and a metastasis rate. In this study, we investigated the role PCK2 TNBC. knockdown suppressed proliferation mTOR signaling cells. addition, cell invasion/migration ability epithelial-to-mesenchymal transition (EMT) markers...