A5042888831- Phagocytosis and Immune Regulation
- Erythrocyte Function and Pathophysiology
- MicroRNA in disease regulation
- Pancreatic function and diabetes
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Immune cells in cancer
- Endodontics and Root Canal Treatments
- Apelin-related biomedical research
- Dental Radiography and Imaging
- Craniofacial Disorders and Treatments
- Cancer-related molecular mechanisms research
- Electrolyte and hormonal disorders
- Reconstructive Surgery and Microvascular Techniques
- Angiogenesis and VEGF in Cancer
- interferon and immune responses
- Lung Cancer Research Studies
- Cancer-related gene regulation
- Histone Deacetylase Inhibitors Research
- Cleft Lip and Palate Research
- Cancer Mechanisms and Therapy
- Natural Compounds in Disease Treatment
- Renal and related cancers
- Cell death mechanisms and regulation
- Autophagy in Disease and Therapy
National Defense Medical Center
2015-2024
Tri-Service General Hospital
2015-2024
Kaohsiung Medical University
2023-2024
National Defense Medical College
2020
American Association of Endodontists
2010
Abstract microRNA (miRNA) dysregulation contributes widely to human cancer but has not been fully assessed in oral cancers. In this study, we conducted a global microarray analysis of miRNA expression 40 pairs betel quid–associated squamous cell carcinoma (OSCC) specimens and their matched nontumorous epithelial counterparts. Eighty-four miRNAs were differentially expressed the OSCC compared with tissue. Among these downregulated miRNAs, 19 found mapped chromosome 14q32.2 cluster region,...
Scope Tumor‐associated macrophages ( TAM s) have been shown to promote metastasis and malignancy. Pterostilbene, a natural stilbene isolated from blueberries, has suggested for anti‐cancer effects. Here, we explored the potential cancer stem cells CSC s)/ modulating effects of pterostilbene in breast cancer. Methods results Using flowcytometric B oyden chamber assay, showed MCF 7 MDA ‐ MB ‐231 cocultured with M 2 s exhibited increased percentage CD 44 + / 24 − population migratory/invasive...
Lung cancer is the leading cause of deaths worldwide and current therapies fail to treat this disease in majority cases. Antrodia camphorata a medicinal mushroom being widely used as food dietary supplement for prevention. The sesquiterpene lactone antrocin most potent among >100 secondary metabolites isolated from A. . However, molecular mechanisms antrocin-mediated anticancer effects remain unclear. In study, we found that inhibited cell proliferation two non-small-cell lung cells, namely...
Abstract Epigenetic correlates of the head and neck cancer may illuminate its pathogenic roots. Through a gene set enrichment analysis, we found that oncogenic transcription factor RUNX2 is widely upregulated in squamous cell carcinoma (HNSCC) with lymph node metastasis, where it also predicts poor prognosis patients HNSCC. Enforced expression ectopic promoted metastatic capabilities HNSCC, whereas silencing inhibited these features. Mechanistic investigations showed manipulating levels...
OBJECTIVE Plasma protein growth arrest–specific 6 (Gas6) is important to the inflammatory process and involved in development of diabetic renal vascular complications. We set out determine whether plasma Gas6 levels are associated with altered glucose tolerance, insulin sensitivity, inflammation, endothelial dysfunction. RESEARCH DESIGN AND METHODS A total 278 adults, including 96 normal tolerance (NGT), 82 impaired (IGT), 100 type 2 diabetes were recruited. concentration biochemical,...
Growth arrest-specific 6 (Gas6) is a vitamin K-dependent protein secreted by immune cells, endothelial vascular smooth muscle and adipocytes. Preclinical studies indicate that Gas6 its receptors of the TAM (Tyro-3, Axl, Mer) family may be involved in pathogenesis obesity complications, including systemic inflammation insulin resistance. Until now, little has been known about clinical significance Gas6/TAM system childhood obesity.This study aimed to determine whether circulating soluble Axl...
The receptor tyrosine kinase Axl and its ligand growth arrest-specific protein 6 (Gas6) are involved in the diabetic vascular disease. aim of this study was to explore role Gas6/Axl system high glucose (HG)-induced endothelial dysfunction. We investigated effect various concentrations on signaling human microvascular cells (HMEC-1 s). Human plasma Gas6 value inversely correlated with status, markers. HG decreased expression increased intercellular adhesion molecule-1 (ICAM-1) cell (VCAM-1)...
Abstract Parathyroid Hormone-Like Hormone (PTHLH) is an autocrine/paracrine ligand that up-regulated in head and neck squamous cell carcinoma (HNSCC). However, the cellular function regulatory mechanism HNSCC remains obscure. We investigated clinical significance of PTHLH patients, verified role RUNX2/PTHLH axis, which stimulated growth. In a poor prognosis marker. expression lead to increasing proliferation potential through elevating blood calcium level Nod-SCID mice. public microarray...
The cytokine-inducible Src homology 2-containing protein (CISH) is an endogenous suppressors of signal transduction and activator transcription (STAT) acts as a key negative regulator inflammatory cytokine responses. Downregulation CISH has been reported to associate with increased activation STAT enhanced pathways. However, whether microRNAs (miRNAs) play crucial role in CISH/STAT regulation oral squamous cell carcinoma (OSCC) remains unknown. expression on OSCC patients was determine by...
Advanced oral cancer is a major public health concern because of lack effective prevention and treatment. Triptolide (TPL), diterpenoid triepoxide derived from the Chinese herb Tripterygium wilfordii, has been demonstrated to possess strong anticancer properties. In this study, we investigated whether TPL exerts effects on tumor microenvironment head neck squamous cell carcinoma (HNSCC).Human macrophage-like U937 cells were co-inoculated with SAS in noncontact transwell coculture system....
Abstract Aims/Introduction Studies suggest that salivary proteins can be used as potential non‐invasive markers for clinical diagnosis and screening diabetes. Previous reports showed plasma alpha 2‐macroglobulin (A2 MG ) levels were higher in diabetic patients, especially with complications. We investigated the relationship between A2 values characteristics patients type 2 Materials Methods A total of 91 adults recruited from our outpatient clinics. The study patients' collected general...
This case report describes the continued root formation following replantation and conventional canal therapy of a traumatically avulsed open-apex tooth with suppurative apical periodontitis. A 7-year-old male patient had an upper left central incisor (tooth 21) replanted approximately 50 min after traumatic avulsion. procedure was initiated due to pulp necrosis periapical abscess detected in follow-up period. After endodontic treatment calcium hydroxide (Ca(OH)(2)) dressing, normal length...
Abstract To investigate the role of thyroid transcription factor-1 (TTF-1) and tumor differentiation in resected lung adenocarcinoma. A total 520 patients with clinical early stage adenocarcinoma who underwent surgical resection were reviewed retrospectively. Clinical data outcomes evaluated an average follow-up 117 months. The results validated via cancer cell line studies. parameters did not differ between relapse nonrelapse patients. Exceptions differentiation, lymphovascular space...
Macrophages participate in the periapical inflammation with pro-inflammatory M1 cells and anti-inflammatory M2 cells. Gas6/Axl signal is responsible pathway for activation of polarization M2. The aim this study was to compare number CD16+ cells, CD206+ expression between apical granulomas radicular cysts.Twenty-four cases granuloma twenty cysts were submitted immunohistochemistry using anti-CD16 anti-CD206 antibodies determining macrophages investigating positive Gas6 Axl expression.There...
Abstract BACKGROUND Loss of E‐cadherin expression is found frequently in many types human malignancies, including mucoepidermoid carcinoma (MEC). CpG methylation the promoter region has proven important regulation gene implicated malignant transformation. DNA methyltransferases (DNMTs) are major enzymes involved establishing genomic patterns. The current study was designed to test hypothesis that may inactivate its and examine DNMT 1 (DNMT1) protein MEC. METHODS Genomic obtained from...
Aims The tyrosine kinase receptor Axl is expressed in the vasculature, and growth arrest-specific protein 6 (Gas6) its ligand. Plasma Gas6 levels have been shown to be associated with endothelial dysfunction markers cardiovascular events. We set out determine plasma patients undergoing coronary artery bypass grafting (CABG) investigate expression of aorta. Methods Results Immunoassays were used CABG (n = 19) control subjects 20). injured aorta examined by reverse transcription-polymerase...
Advanced oral cancer has a poor prognosis because of the lack an effective treatment. We explored efficiency combined treatment with triptolide and ionizing radiation for treating cancer. Human tongue cells were treated triptolide, radiation, or plus radiation. Cell proliferation, cell cycle arrest, apoptotic influences analyzed by FACS immunohistochemistry. Tumor potency was examined in <i>in vivo</i> human xenograft mouse model. Our results demonstrated that caused marked reduction colony...
Sodium hypochlorite (NaOCl) is routinely used as an endodontic irrigant to clean and disinfect the root canal system. Although it generally believed safety, tissue toxicity of NaOCl cannot be ignored. This report describes two cases accidental extrusion sodium solution into periradicular tissues during instrumentation. The literatures were reviewed explore possible etiologies complications. Diagnostic criteria for accidents strategies mitigate risk are also suggested.