A5101714830- Clinical Nutrition and Gastroenterology
- Autophagy in Disease and Therapy
- Phagocytosis and Immune Regulation
- Ion channel regulation and function
- Pancreatic function and diabetes
- Cardiac Ischemia and Reperfusion
- Neuroscience and Neuropharmacology Research
- Metabolism, Diabetes, and Cancer
- Fungal Biology and Applications
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Immune cells in cancer
- Diabetes Management and Research
- Nitric Oxide and Endothelin Effects
- Natural Antidiabetic Agents Studies
- Bioactive Compounds and Antitumor Agents
- Endoplasmic Reticulum Stress and Disease
- Ginseng Biological Effects and Applications
- Organ Transplantation Techniques and Outcomes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Bioactive natural compounds
- Marine Sponges and Natural Products
- Histone Deacetylase Inhibitors Research
- Anesthesia and Neurotoxicity Research
China Medical University
2012-2024
Kaohsiung Medical University
2015-2024
National Pingtung University of Science and Technology
2021-2024
Kaohsiung Medical University Chung-Ho Memorial Hospital
2018-2024
International Baccalaureate
2021-2024
Tri-Service General Hospital
2013-2023
National Defense Medical Center
2013-2023
National Yang Ming Chiao Tung University
2023
Cheng Shiu University
2019-2020
Seascape Consultants (United Kingdom)
2020
Abstract Background The role of intratumoral tumor‐associated macrophages (TAMs) in colorectal cancer (CRC) is not clear. We aim to examine the relationships TAMs and clinicopathologic features CRC expression matrix metalloproteinases (MMP)‐2 MMP‐9. Methods Immunohistochemical staining CD68, MMP‐2, MMP‐9 was determined tissue samples from patients. To test biological effect on tumor cells, cells were cocultured with function change examined. Results Intratumoral TAM count correlated depth...
// Jen-Pi Tsai 1, 2, * , Chien-Hsing Lee 3, 4, Tsung-Ho Ying 5 Chu-Liang Lin 6 Chia-Liang Jung-Tsung Hsueh Yi-Hsien Hsieh 6, 7, 8 1 Department of Nephrology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan 2 School Medicine, University, Hualien, 3 Graduate Institute Medical Sciences, Chang Jung Christian Tainan, 4 Division Pediatric Surgery, Children's Hospital China Taichung, Obstetrics and Gynecology, College Chung Shan Biochemistry, Microbiology Immunology, 7 Clinical laboratory,...
Zinc oxide nanoparticles (ZnO-NPs) are increasingly used in sunscreens, food additives, pigments, rubber manufacture, and electronic materials. Several studies have shown that ZnO-NPs inhibit cell growth induce apoptosis by the production of oxidative stress a variety human cancer cells. However, anti-cancer property molecular mechanism gingival squamous carcinoma (GSCC) not fully understood. In this study, we found induced inhibition GSCC (Ca9-22 OECM-1 cells), but no damage normal...
Abstract Hypoxia inducible factor-1α (HIF-1α) pathway is associated with many vascular diseases, including atherosclerosis, arterial aneurysms, pulmonary hypertension and chronic venous diseases. Significant HIF-1α expression could be found at the rupture edge human abdominal aortic aneurysm (AAA) tissues. While our initial in vitro experiments had shown that deferoxamine (DFO) attenuate angiotensin II (AngII) induced endothelial activations; we unexpectedly DFO augmented severity of...
// Chien-Hsing Lee 1, 2 , Tsung-Ho Ying 3, 4 Hui-Ling Chiou 5 Shu-Ching Hsieh Shiua-Hua Wen 6 Ruey-Hwang Chou 7, 8, * and Yi-Hsien 6, 9, 10, 1 School of Chinese Medicine, College China Medical University, Taichung, Taiwan Division Pediatric Surgery, Department University Children's Hospital, 3 Obstetrics Gynecology, Chung Shan Laboratory Biotechnology, Institute Biochemistry, Microbiology Immunology, 7 Graduate Biomedical Sciences Center for Molecular 8 Asia 9 10 Clinical Laboratory, These...
Abstract Acute hyperglycemia is a frequent finding in patients presenting to the emergency department (ED) with acute myocardial infarction (AMI). The prognostic role of diabetic AMI remains controversial. We retrospectively reviewed patients’ medical records obtain demographic data, clinical presentation, major adverse cardiac events (MACEs), several scores and laboratory including plasma glucose level at initial presentation HbA1c levels. glycemic gap, which represents changes serum levels...
Chemotherapy is the treatment of choice for gastric cancer; however, currently available therapeutic drugs have limited efficacy. Cancer stemness and tumor microenvironment may play crucial roles in growth chemoresistance. Glucose-regulated protein 78 (GRP78) an endoplasmic reticulum chaperone facilitating folding cell homeostasis during stress participate Isoliquiritigenin (ISL) a bioactive flavonoid found licorice. In this study, we demonstrated role GRP78 cancer evaluated GRP78-mediated...
Summary Objective The study aims to evaluate the efficacy of combination therapy with propylthiouracil (PTU) and cholestyramine in treatment Graves’ hyperthyroidism. Background Thyroxine (T4) is metabolized mainly liver by conjugation glucuronides sulphates that enter enterohepatic circulation. Thyrotoxic patients have an abnormal increase thyroid hormone their Previous studies on methimazole for hyperthyroidism shown it be effective adjunctive treatment. In this study, we examined PTU...
Growth arrest-specific 6 (Gas6) is a vitamin K-dependent protein secreted by immune cells, endothelial vascular smooth muscle and adipocytes. Preclinical studies indicate that Gas6 its receptors of the TAM (Tyro-3, Axl, Mer) family may be involved in pathogenesis obesity complications, including systemic inflammation insulin resistance. Until now, little has been known about clinical significance Gas6/TAM system childhood obesity.This study aimed to determine whether circulating soluble Axl...
6-Dehydrogingerdione (6-DG), one important component of ginger, has been reported to possess some medical effects, such as antitumor and antiatherosclerosis. Herein, the anti-inflammatory effects 6-DG against lipopolysaccharides (LPS) induced pro-inflammation mediators in RAW 264.7 cells were investigated. Results show that significantly attenuated inducible nitric oxide synthase (iNOS, NOS2), cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), interleukin 6 (IL-6), tumor necrosis factor-α...
Oxidative stress-mediated cellular injury has been considered as a major cause of neurodegenerative diseases including Alzheimer's and Parkinson's diseases. The scavenging reactive oxygen species (ROS) mediated by antioxidants may be potential strategy for retarding the diseases' progression. Costunolide (CS) is well-known sesquiterpene lactone, used popular herbal remedy, which possesses anti-inflammatory antioxidant activity. This study aimed to investigate protective role CS against...
// Yi-Hsien Hsieh 1, 2, * , Shu-Ching 3, Chien-Hsing Lee 4, 5 Shun-Fa Yang 3 Chun-Wen Cheng 6 Meng-Ju Tang Chia-Liang Lin Chu-Liang Ruey-Hwang Chou 7, 8 1 Department of Biochemistry, School Medicine, Chung Shan Medical University, Taichung, Taiwan 2 Clinical Laboratory, University Hospital, Institute 4 Graduate Sciences, Chang Jung Christian Tainan, Division Pediatric Surgery, Children's Hospital China Microbiology and Immunology, 7 Cancer Biology Center for Molecular Biotechnology, Asia...
Inflammation is a serious health issue worldwide that induces many diseases such as sepsis. There has been vast search for potentially effective drugs to decrease mortality from Pheophytin chlorophyll-related compound derived green tea. We found pre-treatment with pheophytin suppressed lipopolysaccharide (LPS)-induced nitric oxide (NO), prostaglandin E2 (PGE2), and interleukin-1β in RAW 264.7 macrophages. NO synthase-2 (NOS2) cyclooxygenase-2 (COX-2) expression levels were repressed by at...