A5100697165- TGF-β signaling in diseases
- HIV/AIDS drug development and treatment
- Cell Adhesion Molecules Research
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- Caveolin-1 and cellular processes
- HIV Research and Treatment
- Acute Lymphoblastic Leukemia research
- Aquaculture disease management and microbiota
- Cancer Cells and Metastasis
- Genomics and Phylogenetic Studies
- Cancer therapeutics and mechanisms
- Angiogenesis and VEGF in Cancer
- Bone Metabolism and Diseases
- Phytochemistry and Biological Activities
- Kruppel-like factors research
- Inflammatory Bowel Disease
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- Influenza Virus Research Studies
- Cancer, Lipids, and Metabolism
- Metabolism, Diabetes, and Cancer
- Growth Hormone and Insulin-like Growth Factors
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
National Sun Yat-sen University
2016-2025
Shanghai University of Engineering Science
2025
Yichun University
2015-2024
Takeda (United States)
2019-2024
Kaohsiung Medical University
2015-2024
National Museum of Marine Biology and Aquarium
2024
Kaohsiung Armed Forces General Hospital
2013-2024
Zuoying Armed Forces General Hospital
2024
Henan Agricultural University
2023-2024
Fuyang Normal University
2022-2024
Human glutathione S-transferase (GST) M1 and T1 enzymes exhibit genetic polymorphism, with a percentage of normal individuals exhibiting homozygous deletion the relevant genes. We established differential polymerase chain reaction (PCR) technique to simultaneously characterize inactivating mutations responsible for null alleles GSTM1 GSTT1. Primers GSTM1, GSTT1, β-globin (as positive control) were used amplify all three gene products from leukocyte DNA 416 healthy human volunteers. Identical...
Cancer stem cells (CSCs) are subpopulations of tumor masses with unique abilities in self-renewal, stemness maintenance, drug resistance, and the promotion cancer recurrence. Recent studies have suggested that breast CSCs play essential roles chemoresistance. Therefore, new agents selectively target such urgently required. Reactive oxygen species (ROS)-producing enzymes reason for an elevated oxidant status. The nuclear factor erythroid 2-related 2 (Nrf2) is a transcriptional factor, which...
Clathrin-dependent endocytosis is believed to be involved in TGFbeta-stimulated cellular responses, but the subcellular locus at which TGFbeta induces signaling remains unclear. Here, we demonstrate that inhibitors of clathrin-dependent endocytosis, are known arrest progression coated-pit stages, inhibit internalization cell-surface-bound and promote colocalization accumulation TbetaR-I SARA plasma membrane. These enhance TGFbeta-induced responses (Smad2 phosphorylation/nuclear localization...
To date, there are no systematic pharmacokinetic [PK] data on vedolizumab in paediatric inflammatory bowel disease [IBD]. We report results from HUBBLE, a dose-ranging, phase 2 trial evaluating the PK, safety and efficacy of intravenous for IBD.Enrolled patients [aged 2-17 years] with moderate to severe ulcerative colitis [UC] or Crohn's [CD] body weight ≥10 kg were randomized by receive low- high-dose [≥30 kg, 150 300 mg; <30 100 200 mg] Day 1 Weeks 2, 6 14. Week 14 assessments included...
Hypercholesterolemia is a major causative factor for atherosclerotic cardiovascular disease. The molecular mechanisms by which cholesterol initiates and facilitates the process of atherosclerosis are not well understood. Here, we demonstrate that treatment suppresses or attenuates TGF-beta responsiveness in all cell types studied as determined measuring TGF-beta-induced Smad2 phosphorylation nuclear translocation, PAI-1 expression, luciferase reporter gene expression growth inhibition....
A subset of myosin motor proteins binds the membrane phospholipid PIP 3 to link and cytoskeletal dynamics.
CDCA5 plays an important role in the development of various human cancers, but associated mechanisms have not been investigated hepatocellular carcinoma (HCC).We evaluated expression levels and functions HCC showed that is upregulated tissues compared with paired or unpaired normal liver tissues.Increased HCCs was significantly shorter survival patients. Knockdown using lentivirus-mediated shRNA inhibited cell proliferation suppressed survival, as well induced cycle arrest at G2/M phase...
Chemotherapy is the treatment of choice for gastric cancer; however, currently available therapeutic drugs have limited efficacy. Cancer stemness and tumor microenvironment may play crucial roles in growth chemoresistance. Glucose-regulated protein 78 (GRP78) an endoplasmic reticulum chaperone facilitating folding cell homeostasis during stress participate Isoliquiritigenin (ISL) a bioactive flavonoid found licorice. In this study, we demonstrated role GRP78 cancer evaluated GRP78-mediated...
Cancer stemness is the process by which cancer cells acquire chemoresistance and self-renewal in tumor microenvironment. Glucose-regulated protein 78 (GRP78) a biomarker for gastric involved stemness. By inducing various types of cancer, polarization macrophages into tumor-associated (TAMs) controls progression. Betulinic acid (BA) bioactive natural compound with anticancer properties. However, whether GRP78 regulates TAM-mediated microenvironment BA inhibits GRP78-mediated remain unknown....
Abstract Transforming growth factor‐β (TGF‐β) responsiveness in cultured cells can be modulated by TGF‐β partitioning between lipid raft/caveolae‐ and clathrin‐mediated endocytosis pathways. The TβR‐II/TβR‐I binding ratio of on the cell surface has recently been found to a signal that controls these Since cholesterol is structural component rafts/caveolae, we have studied effects receptors animals. Here demonstrate treatment with cholesterol, alone or complexed lipoproteins, decreases while...
Mice deficient in Notch3 have defects arterial vascular smooth muscle cell (VSMC) mechanosensitivity, including impaired myogenic responses and autoregulation, inappropriate VMSC orientation. Experiments were performed to determine if is activated by mechanical stimulation contributes mechanosensitive of VSMCs, realignment. Cyclic, uniaxial stretch (10%, 1 Hz) human VSMCs caused activation, demonstrated a stretch-induced increase hairy enhancer split 1/hairy-related transcription factor-1...
MicroRNA (miRNA) emerges as important player in drug abuse. Yet, their expression profile neurological disorder of cocaine abuse has not been well characterized. Here, we explored the changes miRNA rat hippocampus following repeated exposure and subsequent abstinence from treatment. Conditioned place preference (CPP) procedure was used to assess acquisition extinction cocaine-seeking behavior rats. MiRNA microarray performed examine miRNAs levels hippocampus. Quantitative RT-PCR conducted...
Salmonella is a common intestinal pathogen that causes acute and chronic inflammatory response. Probiotics reduce cytokine production serve as beneficial commensal microorganisms in the human gastrointestinal tract. TGF-β (transforming growth factor β)/SMAD NF-κB signaling play important roles inflammation cells. However, involvement of regulating between probiotics not fully understood.L. acidophilus prebiotic inulin were used to treat Caco-2 cells prior infection with Salmonella. The...
Objective: Myocardial ischemia reperfusion (I/R) damage is a life-threatening vascular emergency after myocardial infarction. Here, we observed the cardioprotective effect of long non-coding RNA (lncRNA) PVT1 knockdown against I/R damage. Methods: This study constructed I/R-induced mouse model and hypoxia/reoxygenation (H/R)-treated H9C2 cells. expression was examined via RT-qPCR. After silencing shRNA PVT1, H&amp;E, Masson staining performed to observe Indicators injury including cTnI,...
Prodigiosin (PG) is a naturally occurring polypyrrole red pigment produced by numerous microorganisms including some
The antibodies of outer membrane proteins (OMPs) bacteria have application value in polyvalent passive vaccines. IgY can be obtained large quantities and economically from egg yolk, the potential to applied aquaculture. OMPs (OmpAII, OmpW, P5, Slp) Aeromonas hydrophila were expressed purified, corresponding prepared. Passive immunization goldfish (Carassius auratus) indicated that four had an effective immune protection rate, could activate innate responses, down-regulated expression...