A5081010297- Advancements in Transdermal Drug Delivery
- Photodynamic Therapy Research Studies
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Dermatology and Skin Diseases
- Skin Protection and Aging
- Advanced Drug Delivery Systems
- Nanoplatforms for cancer theranostics
- Analytical Chemistry and Chromatography
- Bee Products Chemical Analysis
- Hemophilia Treatment and Research
- Kawasaki Disease and Coronary Complications
- Porphyrin and Phthalocyanine Chemistry
- Extracellular vesicles in disease
- Platelet Disorders and Treatments
- Coronary Artery Anomalies
- Mesoporous Materials and Catalysis
- Nonmelanoma Skin Cancer Studies
- Chemotherapy-related skin toxicity
- Lipid Membrane Structure and Behavior
- Lung Cancer Research Studies
- T-cell and Retrovirus Studies
- Synthesis and bioactivity of alkaloids
- Neutropenia and Cancer Infections
- Acne and Rosacea Treatments and Effects
Kaohsiung Medical University
2015-2024
Kaohsiung Medical University Chung-Ho Memorial Hospital
2017-2024
Yuanpei University
2011-2013
Chang Gung University
2003-2006
Taipei Medical University Hospital
2004
Wan Fang Hospital
2004
5-aminolaevulinic acid (ALA) is used as a protoporphyrin IX-precursor for the photodynamic therapy of superficial skin cancer and cutaneous metastases internal malignancies. However, permeability hydrophilic ALA across very low.The objective this study was to optimize enhance in vitro permeation by two resurfacing techniques: erbium:yttrium-aluminium-garnet (Erb:YAG) laser microdermabrasion. Light microscopic changes pig caused these techniques were also compared. The electrically assisted...
Tryptanthrin is an ancient medicine which recently was also found to have a function of downregulating multidrug resistance (MDR). However, tryptanthrin insoluble in water, limits its availability for delivery into cancer cells. There need improve systems increase the inhibition MDR. The aim this study employ nanoparticles encapsulating and promote sustained release drug. approach encapsulate various nanoparticles, including solid lipid (SLNs), nanostructured carriers (NLCs), emulsions...
Chemotherapy is the treatment of choice for gastric cancer; however, currently available therapeutic drugs have limited efficacy. Cancer stemness and tumor microenvironment may play crucial roles in growth chemoresistance. Glucose-regulated protein 78 (GRP78) an endoplasmic reticulum chaperone facilitating folding cell homeostasis during stress participate Isoliquiritigenin (ISL) a bioactive flavonoid found licorice. In this study, we demonstrated role GRP78 cancer evaluated GRP78-mediated...
SN38 (7-ethyl-10-hydroxycamptothecin) is a camptothecin derivative acts against various tumors. However, hydrolyzed in the physiological environment (pH 7.4), and this instability interferes with its potential therapeutic effect. Our objective was to investigate SN38-loaded liposomes overcome poor solubility of biodistribution, which further diminish toxicity.The sub-100 nm targeted employed deliver SN-38 evaluate characterization, release behaviors, cytotoxicity, vivo pharmacokinetics...
Solid lipid nanoparticles (SLNs) are suitable candidates for the delivery of various anti-cancer drugs. However, currently insufficient tumor-permeability and non-specific uptake by reticuloendothelial system limits application SLNs. Here, we developed novel pH-sensitive cationic polyoxyethylene (PEGylated) SLNs (PEG-SLNs+) that could accumulate long-term at tumor sites to enhance therapeutic efficiency camptothecin (CPT). These CPT-loaded PEG-SLNs+ (CPT-PEG-SLNs+) were spherical...
Nanofiber meshes (NFMs) loaded with therapeutic agents are very often employed to treat hard-to-heal wounds such as diabetic wounds. However, most of the NFMs have limited capability load multiple or hydrophilicity distinctive-therapeutic agents. The therapy strategy is therefore significantly hampered. To tackle innate drawback associated drug loading versatility, a chitosan-based nanocapsule-in-nanofiber (NC-in-NF) structural NFM system developed for simultaneous hydrophobic and...
The aim of this study was to develop lipid nanocarriers that combine tretinoin and tetracycline for the efficient topical delivery treat acne vulgaris. Two different nanocarriers, nanoemulsions (NEs) nanostructured carriers (NLCs), were prepared, we examined their average size, zeta potential, drug encapsulation percentage, permeation via skin. antibacterial activities nanosystems against Staphylococcus aureus, Pseudomonas aeruginosa, Propionibacterium acnes evaluated by an agar diffusion...
Triple-negative breast cancer (TNBC) is an aggressive type of with a worse prognosis than other types. There are currently no specific approved treatments for TNBC. Albumin promising biomimetic material that may be fabricated into nanoparticles to possibly exert passive effects on targeted tumors. Irinotecan has been extensively used in clinical settings, although high dosage required due its low efficiency conversion the active metabolite SN-38, also known as...
The synthetic potential chemotherapeutic agent 3-Chloro-4-[(4-methoxyphenyl) amino]furo[2,3-b]quinoline (PK-L4) is an analog of amsacrine. half-life PK-L4 longer than that amsacrine; however, difficult to dissolve in aqueous media, which problematic for administration by intravenous injection.To utilize solid lipid nanoparticles (SLNs) modified with polyethylene glycol (PEG) improve the delivery and investigate its biodistribution behavior after administration.The particle size PK-L4-loaded...
Abstract: Mesoporous silica nanoparticles (MSNs) were synthesized as a promising drug delivery carrier due to the large surface area and porous characteristics. Our previous study successfully recycled wastes from liquid crystal display (LCD) industry precursor. In this study, we substantiated possibility of applying material carrier. MSNs extraction manufacture LCD panels characterized having an average diameter 100 nm, 788 m 2 /g, uniform pore size distribution 3.8 volume up 1.04 cm 3 /g....
Coronary artery aneurysm (CAA) is usually an asymptomatic and rare disease. There are limited epidemiological data for CAA in Asian populations the rest of world. A retrospective case control study. population based, database study from Taiwan's National Health Insurance Research Database, between 2005 2011. patients identified using International Classification Diseases, ninth revision, clinical modification (ICD-9-CM) code 414.11 with examinations. The incidence rate mortality were...
Mitomycin C is an anticancer antibiotic agent that has the potential for broad-spectrum use against several cancers, including mammary cancers. Because its half-life 17 min after a 30 mg intravenous bolus administration, suitability of mitomycin wide in clinical setting limited. Based on tumor pathophysiology, pH-sensitive liposomes could provide better tumor-targeted effects. The aim this study was to investigate possibility diminishing side effect by using liposomes.pH-sensitive employed...
In this study we successfully entrapped 5-aminolevulinic acid (ALA) in liposome, although it exists as a zwitter ion. A molar ratio of 2:1:2.5 phosphatidyle-thanolamine (PE)/cholesterol/sodium stearate represented the best condition to achieve high entrapment efficiency (29.37 ± 1.21%), and average vehicle size was 133.6 2.8 nm. After 32 days storage, sizes formulations with PE series were still approximately less than 200 The safety liposomes tested ensured both regard cellular cytotoxicity...
Belinostat, a histone deacetylase inhibitor used for hematological cancer treatments, however, it caused thrombocytopenia, poor solubility, and rapid clearance. To mitigate these issues, human serum albumin (HSA) was utilized as the core material its high protein binding affinity self-binding capabilities. The study focused on developing belinostat-loaded HSA nanoparticles to improve extend circulation time, reduce adverse effects.