A5062927992- Drug Solubulity and Delivery Systems
- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Psoriasis: Treatment and Pathogenesis
- Nanoparticle-Based Drug Delivery
- Dermatology and Skin Diseases
- Sexual function and dysfunction studies
- Skin Protection and Aging
- Nanoparticles: synthesis and applications
- Pharmacological Effects of Natural Compounds
- Antimicrobial Peptides and Activities
- Analytical Methods in Pharmaceuticals
- Dermatologic Treatments and Research
- RNA Interference and Gene Delivery
- Crystallization and Solubility Studies
- Curcumin's Biomedical Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Inhalation and Respiratory Drug Delivery
- Antimicrobial agents and applications
- Essential Oils and Antimicrobial Activity
- Contact Dermatitis and Allergies
- Antibiotics Pharmacokinetics and Efficacy
- Fungal Biology and Applications
- Extracellular vesicles in disease
Prince Sattam Bin Abdulaziz University
2016-2024
King Saud University
2019
University of Florida
2017
Green synthesis of gold nanoparticles (GNPs) with plant extracts has gained considerable interest in the field biomedicine. Recently, bioreduction nature herbal helped to synthesize spherical GNPs different potential from salt. In this study, a fast ecofriendly method was adopted for using fresh peel (aqueous) Benincasa hispida, which acted as reducing and stabilizing agents. The biosynthesized were characterized by UV–VIS Fourier transform infrared spectroscopy, transmission electron...
Apremilast (APM) is a novel, orally administered small molecule drug approved for treatment of psoriasis or psoriatic arthritis. Due to its low solubility and permeability, it classified as class IV according BCS classification. Dose titration recommended during APM due tolerability twice-daily dosing regimen issues.In this study, three different APM-loaded PLGA nanoparticles (F1-F3) were prepared by single emulsion evaporation method. Based on particle size, PDI, zeta potential (ZP),...
In the current study, four formulae (BNS1-BNS4) of butenafine (BTF) loaded nanosponges (NS) were fabricated by solvent emulsification technology, using different concentration ethyl cellulose (EC) and polyvinyl alcohol (PVA) as a rate retarding polymer surfactant, respectively. Prepared NS characterized for particle size (PS), polydispersity index (PDI), zeta potential (ZP), entrapment efficiency (EE) drug loading (DL). Nanocarrier BNS3 was optimized based on characterizations encapsulation....
The bacterial resistance development due to the incessant administration of antibiotics has led difficulty in their treatment. Natural adjuvant compounds can be co-administered hinder pathogenesis resistant bacteria. Sotolon is prevailing aromatic compound that gives fenugreek its typical smell. In current work, anti-virulence activities sotolon on Pseudomonas aeruginosa have been evaluated. P. treated with at sub-minimum inhibitory concentration (MIC), and production biofilm other virulence...
In the current study, lipid-polymer hybrid nanoparticles (LPHNPs) fabricated with lipoid-90H and chitosan, sunitinib malate (SM), an anticancer drug was loaded using lecithin as a stabilizer by employing emulsion solvent evaporation technique. Four formulations (SLPN1-SLPN4) were developed varying concentration of chitosan polymer. Based on particle characterization, SLPN4 optimized size (439 ± 5.8 nm), PDI (0.269), ZP (+34 5.3 mV), EE (83.03 4.9%). Further, formulation characterized FTIR,...
Nanoparticles have become a focus of interest due to their ability as antibacterial agents. The aim this study was evaluate the anti-methicillin-resistant Staphylococcus aureus (MRSA) activity cationic nanostructured lipid carriers (NLC) combined with oxacillin against ATCC 33591 and clinical isolate. resource on NLC surface soyaethyl morpholinium ethosulfate (SME). loaded produced assess effectiveness topical application for treating cutaneous infection. hydrodynamic diameter zeta potential...
Alveolar macrophages are the first line of defense against intruding pathogens and play a critical role in cancer immunology. The Toll-like receptor (TLR) family mediates an important recognizing mounting immune response microbes. TLR-9 is member intracellular TLR family, which recognizes unmethylated CG motifs from prokaryotic genome. Upon its activation, triggers downstream MyD-88-dependent transcriptional activation NF-κB, subsequently results abundant inflammatory cytokines expression...
Gold nanoparticles are one of the most extensively investigated metallic for several applications. It is less toxic than other nanolattices. The exceptional electrical and thermal conductivity gold make it possible to be administered as non-invasive radiofrequency irradiation therapy that produces sufficient heat kill tumor cells. Nanoparticles generally intravenously instead orally due negligible oral absorption cellular uptake. This study evaluated bioavailability coated with chitosan...
Carvedilol (CRV) is a non-selective third generation beta-blocker used to treat hypertension, congestive heart failure and angina pectoris. Oral administration of CRV showed poor bioavailability (25%), which might be ascribed its extensive first-pass metabolism. Buccal delivery known boost drugs bioavailability. The aim this study investigate the efficacy bilosomes-based mucoadhesive carvedilol nanosponge for enhancing oral CRV. bilosomes were prepared, optimized characterized particle size,...
Olaparib (OLP) is an orally active poly (ADP-ribose) polymerase enzyme inhibitor, approved for treatment the metastatic stage of prostate, pancreatic, breast and ovarian cancer. Due to its low bioavailability, increase in dose frequency required achieve therapeutic benefits, which also results associated toxicity patients. In current study, OLP-loaded (d,l-lactide-co-glycolide) (PLGA) nanoparticles (NPs) (OLP-PLGA NPs) a coating OLP-PLGA NPs with chitosan (CS) (OLP-CS-PLGA were prepared...
Bioinspired nanoparticles enhance the targeting of specific organs by facilitating interactions and communication at nano-bio interface. Combining human neutrophil lung epithelial cell membranes for nanoparticle cloaking offers distinct...
Metallic nanoparticles can be produced in a variety of shapes, sizes, and surface chemistries, making them promising potential tools for drug delivery. Most studies to date have evaluated uptake metallic from the GI tract with methods that are at best semi-quantitative. This study used classical method comparing blood concentration area under curve (AUC) following intravenous oral doses determine bioavailability 1, 2 5 kDa PEG-coated nm gold (AuNPs). Male rats were given single dose (0.8...