A5027632111- Tuberculosis Research and Epidemiology
- Advanced Drug Delivery Systems
- Drug-Induced Hepatotoxicity and Protection
- Chemotherapy-induced organ toxicity mitigation
- Drug Solubulity and Delivery Systems
- Chemotherapy-induced cardiotoxicity and mitigation
- Heavy Metal Exposure and Toxicity
- Multiple Myeloma Research and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Pharmacological Effects of Natural Compounds
- Nanoparticle-Based Drug Delivery
- Renal Diseases and Glomerulopathies
- Medicinal Plants and Neuroprotection
- Analytical Methods in Pharmaceuticals
- Computational Drug Discovery Methods
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacovigilance and Adverse Drug Reactions
- Renal Transplantation Outcomes and Treatments
- Immune Response and Inflammation
- Essential Oils and Antimicrobial Activity
- Curcumin's Biomedical Applications
- Asthma and respiratory diseases
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Advancements in Transdermal Drug Delivery
King Saud University
2016-2025
Glocal University
2025
Karachi Medical and Dental College
2024
Jamia Hamdard
2007-2012
Hamdard University
2010
Torrent Pharma (India)
2006
Dexamethasone (DEX) is a synthetic glucocorticoid with potent anti-inflammatory effects that widely used to treat inflammatory diseases. The aim of the present study was investigate possible protective effect DEX on lipopolysaccharides (LPS)-induced acute lung injury (ALI) in mouse model. Animals were pretreated (5 and 10 mg/kg, i.p.) for seven days induced by intranasal (i.n.) administration LPS day 7. In study, resulted significant increase neutrophils lymphocytes count whereas substantial...
Doxorubicin (Dox) is an anthracycline antibiotic that primarily used for treating various solid tumors including of pulmonary, ovary, breast, uterine, cervix, and several blood cancers. However, nephrotoxicity associated with Dox treatment limits its clinical use. Administration in combination compounds exhibiting antioxidant properties are being to minimize the side effects Dox. Diosmin a flavonoid glycoside numerous beneficial found pericarp many citrus fruits. has demonstrated...
Alzheimer's disease (AD) is a long-term neurodegenerative condition characterized by impaired cognitive functions, particularly in the domains of learning and memory. Finding promising options for AD can be successful with medication repurposing strategy. The goal research was to examine neuroprotective characteristics barbaloin aluminum chloride (AlCl3)-induced deficits changes rats through modulation oxidative stress, cytokines, brain-derived neurotrophic factor (BDNF) expression. Thirty...
For sustainable energy generation, the OER half-cell reaction is an important electrochemical process. In this research article, we have successfully synthesized cost-effective pure g-C3N4, g-C3N4/Cu2O, and g-C3N4/Co-doped Cu2O composite materials using a simple chemical mixing annealing approach to investigate their electrocatalytic performance. All of samples were characterized XRD, FESEM, TEM, BET, XPS, UV–visible DRS techniques. XRD analysis revealed successful synthesis g-C3N4 samples,...
Europinidin is a novel anthocyanidin found in the petals of Plumbago europea that exhibits several physiological effects. Research was conducted to assess europinidin's cardioprotective efficacy diabetic and myocardial infarction (MI) experimental model. Rat injected through intraperitoneal administration 45 mg/kg streptozotocin (STZ), while MI induced by subcutaneously administering 85 isoproterenol (ISP) at 24 48 h prior sacrifice procedure. 10 20 mg/day administered orally for 4 weeks...
The ceramic tiles industry is one of the largest industries globally and expected to grow remarkably in current decade. are a major source decorations for building facades, interior design, etc. manufacturing process heavily dependent on natural raw materials; hence lot research has been carried out integrate various industrial wastes coal ashes its manufacturing. In this project, an effort made optimize developed with incorporation ashes, by predicting flexure strength using different...
Aim: The investigation aimed to study the outcome of rosiridin in Parkinson's disease (PD) induced by rotenone (ROT) rodents. Methods: Rodents were randomized into IV groups and with ROT followed treatment rosiridin. Group I-IV received saline as a vehicle, II-ROT (0.5 mg/kg S.C) for 28 consecutive days, III IV- 10 20 orally ROT. On completion experimental duration, behavioral investigations carried out. Biochemical variables such acetylcholinesterase (AChE), oxidative stress antioxidants...
Carfilzomib (CFZ), is a potent, selective second generation proteasome inhibitor, used for the treatment of multiple myeloma. The aim present study was to investigate possible protective effect apremilast (AP) on CFZ -induced cardiotoxicity. Rats were randomly divided into four groups: Group 1, served as control group, received normal saline. 2, toxic (4 mg/kg, intraperitoneally [i.p.]). Groups 3 and 4, groups, with concomitant oral administration AP in doses 10 20 mg/kg/day, respectively....
Cadmium (Cd), a potent cardiotoxic environmental heavy metal, induces oxidative stress and membrane disturbances in cardiac myocytes. Phosphodiesterase (PDEs) retards the positive inotropic effects of β-adrenoceptor activation by decreasing levels cAMP via degradation. Hence, PDE inhibitors sensitize heart to catecholamine are therefore, used as agents. The present study was designed probe potential attenuating selective PDE4 inhibitor (Roflumilast, ROF), on biomarkers, lipid profile,...
Understanding the appearance of anti-tubercular drug-related adverse drug reactions (ADRs) in patients receiving tuberculosis (TB) treatment is important, and may be related to morbidity mortality if not recognized early. Here, we aimed characterize mechanisms underlying due combination anti-tuberculosis therapy Revised National Tuberculosis Control Program (RNTCP). This was a prospective observational study conducted 9 DOTS centers New Delhi, India. All enrolled TB first-line as per RNTCP...
Delafloxacin (DFL) is a novel potent and broad-spectrum fluoroquinolone group of antibiotics effective against both Gram-positive negative aerobic anaerobic bacteria. In this study, DFL-loaded stearic acid (lipid) chitosan (polymer) hybrid nanoparticles (L-P-NPs) have been developed by single-emulsion-solvent evaporation technique. The mean particle size polydispersity index (PDI) optimized L-P-NPs (F1-F3) were measured in the range 299-368 nm 0.215-0.269, respectively. drug encapsulation...
Recent research has shown that phytocomponents may be useful in the treatment of renal toxicity. This study was conducted to evaluate disease hirsutidin paradigm toxicity induced by cisplatin. Male Wistar rats were given cisplatin (3 mg/kg body weight/day, for 25 days, i.p.) induce Experimental randomly allocated four different groups: group I received saline, II cisplatin, III + (10 mg/kg) and IV (per se) m/kg) days. Various biochemical parameters assessed, oxidative stress (superoxide...
Memory loss or dementia is a progressive disorder, and one of its common forms Alzheimer's disease (AD), effecting mostly middle aged older adults. In the present study, we developed Rivastigmine (RIV) nanoparticles using poly(lactic-co-glycolic acid) (RIV-loaded PLGA NPs) polyvinyl alcohol (PVA). The prepared RIV-PLGA was evaluated for management (AD). were by slightly modified nano-precipitation technique. formulations particle size, zeta potential (ZP), polydispersibility index (PDI)...