Quercetin (QR), is a polyphenolic flavonoid compound which found in large amounts certain foods, and protects against oxidative stress. The current study was conducted to determine whether can possibly exert hepatoprotective antioxidant activity acrylamide (ACR) induced toxicity rats.Four groups of Wistar rats consisting six each: (i) control group; (ii) ACR treated group (50 mg/kg bw); (iii) QR group: were with (10 (iv) bw) given i.p. for 5 days followed by on 5th day (single dose).ACR...

This study was designed to evaluate the effect of rutin on hepatotoxicity induced by thioacetamide (TAA) in rats. Four groups male Wistar rats consisting six each were used: Group I: control group; II: receiving single injection 300 mg kg-1 body weight TAA intraperitoneally; III: administered (10 weight) dissolved saline orally for 2 weeks; and IV: weeks followed last day second week. All sacrificed after 24 h treatment hepatic toxicity analyzed with respect liver markers, DNA fragmentation,...

Colon cancer is a world-wide health problem and one of the most dangerous type cancer, affecting both men women. Naringenin (4, 5, 7-trihydroxyflavanone) major flavone glycoside present in citrus fruits. has long been used Chinese's traditional medicine because its exceptional pharmacological properties non-toxic nature. In study, we investigated chemopreventive potential against 1,2-dimethyhydrazine (DMH)-induced precancerous lesions, that is, aberrant crypt foci (ACF) mucin depleted (MDF),...

Development of diabetic nephropathy (DN) is directly linked to oxidative stress and inflammation. In this context, inflammatory markers have gained much attention as targets for therapeutic intervention. We studied the effect zingerone in a streptozotocin/high fat diet (STZ/HFD)-induced type 2 Wistar rat model. Zingerone also known vanillyl acetone pharmacologically active compound present usually dry ginger. STZ/HFD caused excessive increase ROS inflammation experimental animals. The...

This study is undertaken to investigate the effects of naringenin on doxorubicin- (Dox) induced nephrotoxicity in Wistar rats. Dox 10 mg/kg body weight was administered intraperitoneally once and 50 100 orally daily for 21 d. Dox-induced oxidative stress lead steep elevation blood urea nitrogen (BUN), creatinine, lactate dehydrogenase (LDH), kidney injury molecule-1 (KIM-1), compared control, treatment with preserved functions. With significant decrease antioxidant enzymes increase...

Background: The cardiovascular crisis is advancing rapidly throughout the world. A large number of studies have shown that plant polyphenols affect major mechanisms involved in events through their action on antioxidant system, signaling, and transcription pathways. D-limonene, a monocyclic monoterpene obtained from citrus fruits, reported to possess many pharmacological activities.Methods: experiment was designed determine protective effect D-limonene against cardiac injury induced by CCl4...

Abstract Colorectal cancer is one of the most common cancers worldwide. Development naturally occurring inexpensive and safe alternatives can be effective in suppressing colon related proliferations. Zingerone (4‐[4‐hydroxy‐3‐methylphenyl] butan‐2‐one), a polyphenolic alkanone ginger, has massive pharmacological properties thus used as promising candidate against various ailments. In current study, we aimed at demonstrating protective effect zingerone experimental carcinogenesis elucidating...

Cadmium (Cd), a potent cardiotoxic environmental heavy metal, induces oxidative stress and membrane disturbances in cardiac myocytes. Phosphodiesterase (PDEs) retards the positive inotropic effects of β-adrenoceptor activation by decreasing levels cAMP via degradation. Hence, PDE inhibitors sensitize heart to catecholamine are therefore, used as agents. The present study was designed probe potential attenuating selective PDE4 inhibitor (Roflumilast, ROF), on biomarkers, lipid profile,...

Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that causes irritation, inflammation, and ulceration in the linings of colon rectum. Otostegia fruticosa traditionally used to treat various disorders different parts Middle East sub-Saharan Africa. In present study, we evaluated ameliorative effects crude leaves extract O. (OF.Cr) on acetic acid (AA)-induced UC model Wistar albino rats. rats were administered orally with either vehicle (10 mL/kg), OF.Cr (200 400 mg/kg), or...

Current research focuses on explicitly developing and evaluating nanostructured lipidic carriers (NLCs) for the chemotherapeutic drug Ribociclib (RCB) via topical route to surmount inherent bioavailability shortcomings. The absolute oral has not been determined, but using a physiologically based pharmacokinetic model it was predicted that 65.8 % of standard dose RCB (600 mg) would be absorbed mainly in small intestine. RCB-NLCs were produced solvent evaporation method, Box-Behnken Design...

Commiphora myrrha (Burseraceae), a shrub resembling small tree, has been used for several centuries the treatment of various diseases.This study investigates hepatoprotective activity C. ethanol extract against d-galactosamine/lipopolysaccharide (d-GalN/LPS)-induced acute hepatic injury in an animal model.Rats were pretreated with ethanolic (250 and 500 mg/kg; p.o.) 7 d prior to induction phase response by d-GalN/LPS. Animals sacrificed 24 h after d-GalN/LPS (800 mg/kg 50 µg/kg i.p.)...

In this era of urbanization and environmental pollution, antioxidants antimutagens derived from plants are promising safeguards for human health. the current investigation, we analyzed antioxidant antimutagenic effects hexane, chloroform, ethyl acetate fractions Rhododendron arboreum Sm. leaves determined their chemical composition. The different inhibited lipid peroxidation, repressed production nitric oxide radicals, prevented deoxyribose degradation. activity leaf was against...

The aim of the current study was to evaluate and compare toxicities different types mosquito repellents i.e. coils, mats liquid vapors in animal models. Different including vaporizers, coils have been extensively used by people get protection from mosquitoes diseases associated with them. active constituents these include; allethrins, pyrethrins, paraffin various other derivatives, are well known for their toxicities. Exposure albino mice 3 h per day over a period 20 days produced...

A C TIn the present study, DPPH radical scavenging assay and ferric-reducing antioxidant were used to evaluate in vitro potential of methanol extract Ferula duranii (F.duranii).The antihyperglycemic antihyperlipidemic activities F. evaluated streptozotocin (STZ)-induced diabetic rats.F. showed considerable minimum reducing power assay.A meaningful reduction concentrations Fasting Blood Glucose (FBG), glycosylated hemoglobin (Hb A1c), triglycerides (TG), Total Cholesterol (TC) Low Density...

Background: The poor oral bioavailability of newly discovered chemical entities and marketed formulations are usually related to aqueous solubility or permeability, leading drug failure in the development phases therapeutic a clinical setting. However, advancement delivery technologies have enabled scientists improve by enhancing permeability. Objective: This study reports enhancement ibrutinib (IBR), poorly soluble anticancer Wistar albino rats. Methods: IBR loaded nanoparticles were...

Rumex vesicarius L. (Polygonaceae), an edible plant, is reported to have many bioactive phytochemicals, especially flavonoids and anthraquinones with antioxidant detoxifying properties.This study evaluated the methanolic extract of R. vasicarius (MERV) for hepatoprotective activity in rats against CCl4-induced liver damage.The whole plant was prepared investigated its activity. Rats were pretreated MERV (100 200 mg/kg, p.o.) 7 d prior induction damage by CCl4. Animals then sacrificed 24 h...

To assess in-vitro antioxidant activity of different fraction and perform high performance thin layer chromatography fingerprint analysis most active Rumex vesicarius L. (R. vesicarius). In the present study, acetone, ethyl acetate, n-butanol, methanol extracts R. were evaluated for radical scavenging by studying inhibition level lipid peroxidation induced Fe(++)/ascorbate, DNA sugar damage, hydrogen peroxide, diphenylphosphine DPPH activity, total phenolic content, flavonoids content...