A5017365328- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Essential Oils and Antimicrobial Activity
- Lipid Membrane Structure and Behavior
- Drug Solubulity and Delivery Systems
- Pharmacological Effects of Natural Compounds
- Natural Antidiabetic Agents Studies
- Dermatology and Skin Diseases
- Nigella sativa pharmacological applications
- Drug-Induced Hepatotoxicity and Protection
- Bee Products Chemical Analysis
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Analytical Chemistry and Chromatography
- Pharmacological Effects and Toxicity Studies
- Complementary and Alternative Medicine Studies
- Analytical Methods in Pharmaceuticals
- Crystallization and Solubility Studies
- Natural product bioactivities and synthesis
- Curcumin's Biomedical Applications
- Phytochemicals and Antioxidant Activities
- Pesticide Residue Analysis and Safety
- Food Science and Nutritional Studies
- Antibiotics Pharmacokinetics and Efficacy
- Ocular Infections and Treatments
King Saud University
2016-2025
Aligarh Muslim University
2024
National Cancer Institute
2022-2024
National Institutes of Health
2024
Center for Cancer Research
2022-2024
Pakistan Agricultural Research Council
2023
Nishtar Medical College and Hospital
2020-2023
Liaquat National Hospital
2023
Pakistan Council of Scientific & Industrial Research
2023
Fuzzy Systems Institute
2023
The aim of the present work was to investigate efficacy temozolomide nanostructured lipid carriers (TMZ-NLCs) enhance brain targeting via nasal route administration. formulation optimized by applying a four-factor, three-level Box-Behnken design. developed formulations and functional relationships between their independent dependent variables were observed. used in gelucire (X1), liquid lipid/total (X2), Tween 80 (X3), sonication time (X4), effects observed with regard size (Y1), % drug...
The present study was conducted for the optimization of transethosomes formulation dermal fisetin delivery. carried out using "Box–Behnken design". independent variables were Lipoid S 100, ethanol and sodium cholate. prepared formulations characterized vesicle size, entrapment efficiency in vitro skin penetration study. vesicles–skin interaction, confocal laser scanning microscopy dermatokinetic studies performed with optimized formulation. Results demonstrated that presented size 74.21 ±...
The objective of the present work was to formulate, optimize and evaluate potential novel soft nanovesicles i.e. nano-transfersomes, containing eprosartan mesylate (EM) for transdermal delivery. Nano-transfersomes EM were developed using Phospholipon 90G, Span 80 (SP) sodium deoxycholate (SDC) characterized vesicle size, shape, entrapment efficiency, in vitro skin permeation study confocal laser scanning microscopy. optimized nano-transfersomes formulation showed vesicles size 108.53 ± 0.06...
Background: In the current study, we evaluated therapeutic potential of sinapic acid (SA) in terms mechanism underlying its gastroprotective action against ethanol-induced gastric ulcers rats. Methods: These effects were examined through gross macroscopic evaluation stomach cavity [gastric ulcer index (GUI)], alteration pH, juice volume, free acidity, total wall mucus, and changes PGE2. addition, lipid peroxidation (malondialdehyde), antioxidant systems (catalase glutathione), inflammatory...
: Ulcerative colitis (UC) is a long-term condition which results in inflammation and ulcers of the colon rectum. The key indications active disease are abdominal pain diarrhea mixed with blood.
The objective of the current study was to formulate eprosartan mesylate loaded transfersomes using different proportions Phospholipon® 90 G and Tween® 80 (95–75:5–25% w/w). prepared were characterized for their vesicles size, shape, polydispersity index, zeta potential, entrapment efficiency, in vitro skin permeation, confocal laser scanning microscopy, vivo irritation. Results revealed that formulated negatively charged, spherical unilamellar structure 71.18–85.66 nm with efficiency...
Objective: The aim of the present study was to develop and optimize topically applied nimesulide-loaded nanostructured lipid carriers. Materials methods: Box–Behnken experimental design for optimization independent variables were ratio stearic acid: oleic acid (X1), poloxamer 188 concentration (X2) lecithin (X3) while particle size (Y1) entrapment efficiency (Y2) chosen responses. Further, skin penetration study, in vitro release, confocal laser scanning microscopy stability also performed....
Context Isradipine is an effective calcium channel blocker used in the management of hypertension. It undergoes extensive first pass metabolism and has low oral bioavailability. Hence we attempted to develop isradipine-loaded invasomes. Objective The purpose this work was prepare characterize invasomes carrier for isradipine, evaluate optimized formulation obtained pharmacodynamic study. Materials methods Isradipine-loaded were prepared by conventional thin layer evaporation technique using...