Peptic ulcer is the most common gastrointestinal tract (GIT) disorder in clinical practice, which affects approximately 5-10% of people during their life. The use herbal drugs for prevention and treatment various diseases constantly developing throughout world. This particularly true with regard to phenolic compounds that probably constitute largest group plants secondary metabolites. Phenolic have attracted special attention due health-promoting characteristics. In past ten years a large...

Diabetes mellitus is a complicated metabolic disorder that has gravely troubled the human health and quality of life. Conventional agents are being used to control diabetes along with lifestyle management. However, they not entirely effective no one ever been reported have fully recovered from diabetes. Numerous medicinal plants for management in various traditional systems medicine worldwide as great source biological constituents many them known be against Medicinal antihyperglycemic...

With the constant failure of clinical trials continuous exploration a therapeutic target against Alzheimer's disease (AD) is utmost need. Numerous studies have supported hypothesis that central insulin resistance plays significant role in AD. Serine phosphorylation Insulin Receptor Substarte-1 (IRS-1) has been found to be contributing factor neuronal resistance. Astaxanthin (ASX) xanthophyll carotenoid which previously demonstrated antidiabetic and neuroprotective actions. In present study,...

Diabetic kidney disease (DKD) is a major public health problem characterized by elevated urine albumin excretion or reduced glomerular filtration rate both. The pathophysiology of DKD involves various pathways like hemodynamic, metabolic, and inflammatory pathways. Increase in reactive oxygen species formation induced hyperglycemia through activation electron transport chain considered as the initiators development diabetes complications. Prevalence raising continuously with disparate growth...

Riluzole is the only available drug for motor neuron diseases quite well-known its neuroprotective activity. But poor aqueous solubility, short half-life with some side-effects at higher concentration poses a limitation to use as therapeutic agent. The present study was performed investigate potential of nanoriluzole (NR), i.e., riluzole encapsulated in nanoparticles against cerebral ischemia (stroke) three different concentrations [10 (NRL), 20 (NRM), and 40 (NRH) μg/kg body weight...

Silymarin is a bioactive constituent isolated from milk thistle (Silybum marinum). Since its discovery, silymarin has been considered gold standard drug in treating ailments related to the liver, resulting alcohol consumption and viral hepatitis. This hepatoprotective nature of arises out antioxidative tissue-regenerating properties silymarin. However, several recent studies have established neuroprotective link silymarin, too. Thus, current investigation was aimed at exploring effect...

Alzheimer's disease (AD) presents a significant challenge due to cognitive decline resulting from nerve cell degeneration. Shatavarin IV, prominent bioactive compound fromAsparagus racemosus and Piracetam, has been investigated for its neuroprotective potential. This study examines the molecular docking, formulation, characterization of nanoemulsion containing Piracetam IV treating AD. The in silico demonstrated that exhibited strong binding affinities with multiple AD-related targets,...

The present study was conducted to investigate the protective effect of dried berries Myrtus communis L. in gastric ulcer against ethanol, indomethacin and pyloric ligation induced models Wistar rats. Two doses aqueous extracts M. (AE 1 AE 2 ) at dose 105 175 mg/kg, respectively, methanolic (ME ME 93 154 were administered orally animals prior exposure ulcerogens. parameters taken assess anti-ulcer activity index, juice volume, pH, total acidity, wall mucus histopathological studies. Oral...

Objectives: The present study was designed to evaluate the cardioprotective potential of edaravone on oxidative stress, anti-apoptotic, anti-inflammatory and ultrastructure findings in isoproterenol (ISO) induced myocardial infarction (MI) rats.Methods: Rats were pretreated with (1, 3, 10 mg/kg body weight-1 day-1) intraperitoneally. MI by subcutaneous administration ISO (85 weight-1) at two doses 24h interval.Results: treated rats showed significant increase levels thiobarbituric acid...

Aqueous and hydroalcoholic extracts of Nigella sativa (400 mg/kg, orally) for 7 days were administered evaluated their neuroprotective effects on middle cerebral artery occluded (MCAO) rats.Cerebral ischemia was induced by occlusion 2 h followed reperfusion 22 h. After 24 ischemia, grip strength, locomotor activity tests performed in the surgically operated animals. behavioral tests, animals immediately sacrificed. Infarct volumes estimation markers oxidative stress brains measured.Locomotor...

Abstract Aim In the present study quercetin was studied for its role in inflammation, oxidative stress markers and 5-HT levels unpredictable chronic mild (UCMS) animal model of depression. Materials Methods The mice were randomized into different groups trained UCMS protocol followed by drug treatments. Treatments started after 2 weeks from start continued up to 6 weeks. behavioral tests such as modified forced swimming (MFST), tail suspension (TST) open field performed on week 6, at least...

The current study aimed to develop alendronate (ALN)-loaded chitosan nanoparticles (CS-ALN-NPs) for brain delivery via intranasal route. These CS-ALN-NPs reduced the peripheral side effects and released ALN directly brain. NPs were formulated through ionic gelation technique by mixing sodium tripolyphosphate (1.5 mg/ml) in ALN-CS (1.75 solution. attained 135.75 ± 5.80 nm, 0.21 0.013, 23.8 3.69 mV, 72.46 0.879% 30.92 0.375% mean particle size, PDI, zeta potential, entrapment efficiency...