A5060245167- Vitamin D Research Studies
- Estrogen and related hormone effects
- Epigenetics and DNA Methylation
- Cholinesterase and Neurodegenerative Diseases
- Graphene and Nanomaterials Applications
- Clusterin in disease pathology
- Synthesis and biological activity
- Cancer, Lipids, and Metabolism
- Seaweed-derived Bioactive Compounds
- Medicinal Plants and Neuroprotection
- Iron Metabolism and Disorders
- Nanoparticles: synthesis and applications
- Lipid Membrane Structure and Behavior
- Long-Term Effects of COVID-19
- Nanoparticle-Based Drug Delivery
- Curcumin's Biomedical Applications
- COVID-19 Clinical Research Studies
- Advancements in Transdermal Drug Delivery
- Alkaloids: synthesis and pharmacology
- Ginger and Zingiberaceae research
- Melanoma and MAPK Pathways
- S100 Proteins and Annexins
- Phytochemical and Pharmacological Studies
- Apelin-related biomedical research
- Moringa oleifera research and applications
King Saud University
2001-2025
Weatherford College
2020
Abstract Seaweeds are a group of marine multicellular algae; the presence antioxidant phytochemical constituents in Seaweed Chaetomorpha sp . extracts has received attention for their role prevention human diseases. This study explores constituents, antioxidant, and anticancer properties Cladophoraceae, Energy dispersive x-ray spectroscopy (EDX), Gas chromatography-mass spectrometry (GC/MS) were performed to chemical structure formula. Different concentrations ethanol aqueous used estimate...
The current study explores the potential of melatonin (MLT)-loaded solid lipid nanoparticles (MLT-SLNs) for better neuroprotective effects in ischemic stroke. MLT-SLNs were prepared using matrix palmityl alcohol with a mixture surfactants (Tween 40, Span Myrj 52) stabilizing matrix. tested physical and chemical properties, thermal polymorphic changes, vitro drug release vivo studies rats permanent middle cerebral artery occlusion (p-MCAO) model. optimized showed particle size ∼159 nm, zeta...
This study was designed to evaluate the effect of rutin on hepatotoxicity induced by thioacetamide (TAA) in rats. Four groups male Wistar rats consisting six each were used: Group I: control group; II: receiving single injection 300 mg kg-1 body weight TAA intraperitoneally; III: administered (10 weight) dissolved saline orally for 2 weeks; and IV: weeks followed last day second week. All sacrificed after 24 h treatment hepatic toxicity analyzed with respect liver markers, DNA fragmentation,...
Oxidative stress results from an imbalance between free radical production and antioxidant defense, significantly impacting neonatal health, particularly in preterm infants with immature systems. This study aims to assess oxidative Saudi neonates by measuring key antioxidants, both enzymatic (superoxide dismutase, catalase, glutathione peroxidase) nonenzymatic (glutathione, bilirubin, uric acid), comparing them across sex (male vs female) term status (full preterm). A total of 110 (55 normal...
Alzheimer disease is a progressive neurodegenerative disease, affecting very high proportion of the aging population. Several studies have demonstrated that one main contributors to this oxidative stress (OS), which causes peroxidation protein, lipids, and DNA resulting in formation advanced glycosylated end products (AGE) brain tissues. These AGE are usually associated with amyloid β (Aβ), could further aggravate its toxicity clearance. Antioxidants counteract deterioration caused by OS.We...
Rosa webbiana L. (Rosaceae) is one of the least reported and most understudied members this family. It native to Himalayan regions Pakistan Nepal. The anti-convulsant effect n-hexane extract fruit was investigated in a pentylenetetrazole (PTZ)-induced animal model epilepsy. Male Sprague-Dawley rats were divided into six groups (n = 7) including control, PTZ (40 mg/kg), diazepam (4 mg/kg) (at 50, 150 300 mg/kg). Convulsive behavior observed resultant seizures scored, animals sacrificed their...
Isatin, a heterocycle scaffold, is the backbone of many anticancer drugs and has previously been reported to engage multiple cellular targets mechanisms, including angiogenesis, cell cycle, checkpoint pathways kinases. Here, we report that novel isatin derivative, 5i, degrades estrogen receptor alpha (ERα) in estrogen-dependent breast cancer cells. This effect nucleus not reported. Tamoxifen fulvestrant represent standard therapy options estrogen-mediated disease but have their own...
Dysregulation of renin−angiotensin systems during coronavirus disease 2019 (COVID-19) infection worsens the symptoms and contributes to COVID-19 severity mortality. This study sought investigate effect exogenous angiotensin II (Ang-II) on severe acute respiratory syndrome 2 (SARS-CoV-2)-specific T-cells response in recovered patients. Human peripheral blood mononuclear cells (PBMCs) were treated with Ang then stimulated a SARS-CoV-2 peptide pool. T-cell responses measured using flow...
The aggressive triple-negative breast cancer (TNBC) is a challenging disease due to the absence of tailored therapy. search for new therapies involves intensive research focusing on natural sources. Achillea fragrantissima (A. fragrantissima) traditional medicine from Middle East region. Various solvent extracts different A. plant parts, including flowers, leaves, and roots, were tested TNBC MDA-MB-231 cells. Using liquid chromatography, fingerprinting revealed rich diverse compositions...
Compelling evidence from epidemiological and experimental studies indicate that the disruption of circadian rhythm decreased melatonin synthesis are risk factors for breast cancer. With ever-increasing rate cancer cases globally, there is a strong need safer, effective, alternate treatment strategies with lesser side effects. This study aimed to investigate effects vitamin D3 on gene expression two apoptotic factors, BCL-2 Bax, in MCF-7 cell line. Cell viability (MCF-7) was studied through...
Poor aqueous solubility of eplerenone (EPL) is a major obstacle to achieve sufficient bioavailability after oral administration. In this study, we aimed develop and evaluate nanocrystals (EPL-NCs) for dissolution enhancement. D-optimal combined mixture process using Design-Expert software was employed generate different combinations optimization. EPL-NCs were prepared by bottom-up, controlled crystallization technique during freeze-drying. The optimized evaluated their size, morphology,...
Cisplatin resistance is a major concern in ovarian cancer treatment. The aim of this study was to investigate if wedelolactone could perform better resistant cells when used combination with cisplatin.Growth inhibitory potential and cisplatin investigated through MTT reduction assay cell lines including A2780 (sensitive), A2780cisR (cisplatin resistant) A2780ZD0473R. Resistance factor (RF) drugs determined these three lines. Combination index (CI) calculated as measure combined drug action....
Highlights•This Novel Brain slice culture described here proved to be useful for the study of therapeutic potential various drugs.•Quercetin has shown ameliorate induced oxidative stress brain Tissues specially neurons in-vitro.•Supplementation with Quercetin could potentially use as therapy neurodegenerative disorder.SummaryPurposeQuercetin (QR) is bioflavonoids known its antioxidants property and ability alleviate promote cellular survival. The aim this was explore neuroprotective QR...
Acute myeloid leukaemia (AML) is characterized by uncontrolled proliferation of progenitor cells and impaired maturation, leading to immature cell accumulation in the bone marrow bloodstream, resulting hematopoietic dysfunction. Chemoresistance, hyperactivity survival pathways, miRNA alteration are major factors contributing treatment failure poor outcomes AML patients. This study aimed investigate impact pharmacological p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580 on...
Micronutrient deficiencies, including iron deficiency, are linked to different cognitive impairments and sensory functions. However, whether circulating levels affect self-assessed multiple intelligence (MI) scores in adolescents remains uninvestigated. This study aimed investigate associations between serum MI Riyadh, Saudi Arabia. Recruiting 434 (174 boys 260 girls, aged 12-17), we administered the McKenzie questionnaire assess across nine categories. Anthropometrics fasting blood samples...
Asprosin, a novel adipokine, has been implicated in glucose regulation, insulin production, and appetite stimulation. Hence, the current study explores circulating asprosin levels their associations with resistance (IR) other parameters obese type 2 diabetes mellitus (T2DM) Saudi subjects. A total of N = 291 (89 control, 105 T2DM/obese 97 obese) subjects were included this cross-sectional study. Fasting lipid profiles measured routinely. Adiponectin, leptin, C-reactive protein (CRP), tumor...
In the wake of warning by WHO that prevalence dementia may have a rise 125% in Middle East 2050, identification genetic risk factors Arab populations is urgent.To investigate association Single Nucleotide Polymorphisms (SNPs) apolipoprotein E (ApoE), clusterin (CLU), tumor necrotic factor- α (TNF-α) and interleukin-6 (IL-6) genes, with Alzheimer's disease (AD) Saudi Arabian participants.A total 42 AD patients 23 age-matched control participants were genotyped for eight SNPs: rs429358, rs7412...
Abstract Osteoporosis is reported to be common among Saudi women. Several minerals appear important determinants of insulin-like growth factor (IGF), the bioactivity which regulates bone and mineral metabolism. Here we proposed that status may alter IGF system individuals with osteoporosis. This study aims evaluate relationships between essential elements levels postmenopausal women A total 128 aged ≥50 years old were recruited in this study. Diagnosis osteoporosis was done by using...
Background and Objective: Seaweeds are considered as a potential source of antioxidant which reduces the risk some diseases good new drugs with lower side effect toxicity.This study aimed to estimate activity Rhodophyta algae genus Polysiphonia Laurencia (Rhodomelaceae, Ceramiales).Materials Methods: Samples were collected from different regions Arabian Gulf.Antioxidant represented by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, total flavonoid, phenolic tannin content...