To assess the available evidence for diagnostic accuracy of CSF testing protein 14-3-3 in patients with suspected sporadic Creutzfeldt-Jakob disease (sCJD).The authors performed a systematic review literature from 1995 to January 1, 2011, identify articles involving who were having sCJD and had analysis 14-3-3. Studies rated according American Academy Neurology classification scheme studies, recommendations linked strength evidence. A pooled estimate sensitivity specificity was obtained all...

We aimed to assess the prevalence of headache and migraine, along with comorbidities, in a large -Saudi sample.Self-reported information was collected about headache, migraine comorbidities including depression, restless legs syndrome (RLS), syncope, bruxism, hypertension ischaemic disease. The OR estimated using logistic regression for any associations migraine. then analyzed find trend increasing symptoms each significant comorbidity.Out 4,943 respondents, 4,158 (84.12%) had recurring...

<b><i>Background:</i></b><i>N</i>-methyl-D-aspartic acid antagonists (memantine) and cholinesterase inhibitors (ChEIs) are the only two approved classes of drugs to treat dementia; this paper explores evidence for using these treatments in combination. <b><i>Objective:</i></b> To determine efficacy safety combination therapy with memantine a ChEI dementia comparison monotherapy either or ChEI....

According to published literature status epilepticus (SE) is associated with 7-39% mortality. Timely management one variable that potentially influences the outcome. We sought review process of acute SE at University Alberta Hospital and correlate outcome adherence a recommended treatment protocol.We identified 86 patients 18 years age or older who presented convulsive our emergency room between 2000 2004. defined as continuous activity for 30 more minutes >or= 2 convulsions incomplete...

Case 1: A previously healthy 51-year-old man came to hospital complaining of headache 3 weeks' duration and several days nausea, vomiting confusion. He had some difficulty recalling the events preceding weeks, but results his general neurologic examinations were

Abstract Background The revised 15‐item Myasthenia Gravis (MG) Quality of Life Questionnaire (MGQoL15R) is a validated scale quality life in patients with MG. We aimed to study the factors causing variability within Arabic version MGQoL15R (MGQoL15R‐A). Method A standardized questionnaire was completed by 118 patients. Correlations and hierarchical regression analyses were used assess contribution sociodemographic variables, clinical factors, Patient Health Questionnaire‐9 (PHQ9‐A),...

Currently, there are standard and basic versions of the MoCA, latter designed for those with lower educational achievements. Community-based normative data on these MoCA from Arabic populations deficient, is little demonstrating how both scales perform in comparison. We aim to obtain performances equate measures scales.Community-based recruitment healthy volunteers ≥ 18 years age. Participants underwent testing versions. Demographic was collected regard age, gender, education, diabetes,...

ABSTRACT Introduction : This study was undertaken to describe a method for quantifying vibration when using conventional tuning fork (CTF) in comparison Rydel‐Seiffer (RSTF) and provide reference values. Methods Vibration thresholds at index finger big toe were obtained 281 participants. Spearman's correlations performed. Age, weight, height analyzed their covariate effects on threshold. Reference values the fifth percentile by quantile regression. Results The correlation coefficients...

Little is known of how accurately a first-time seizure witness can provide reliable details semiology. Our goal was to determine witnesses could identify key elements an epileptic event that would aid the clinician in diagnosing seizure.A total 172 participants over 17 years age, with mean (sd) 33.12 (13.2) and 49.4% female, composed two groups community dwelling volunteers, were shown different videos; one focal generalized (GSV), other partial did not generalize (PSV). Participants first...

In the wake of warning by WHO that prevalence dementia may have a rise 125% in Middle East 2050, identification genetic risk factors Arab populations is urgent.To investigate association Single Nucleotide Polymorphisms (SNPs) apolipoprotein E (ApoE), clusterin (CLU), tumor necrotic factor- α (TNF-α) and interleukin-6 (IL-6) genes, with Alzheimer's disease (AD) Saudi Arabian participants.A total 42 AD patients 23 age-matched control participants were genotyped for eight SNPs: rs429358, rs7412...

ABSTRACT Introduction : We sought to translate, culturally adapt, and assess the Arabic version of 15‐item myasthenia gravis quality‐of‐life revised scale (MGQOL15R). Methods assessed reliability with Cronbach α; reproducibility intraclass correlation coefficient (ICC); validity Spearman correlations for (MG)‐specific activities daily living (MG‐ADL), MG composite (MGC) score, manual muscle test (MG‐MMT) MGQOL15R in patients different disease severity through Kruskal–Wallis test; sensitivity...

Only a small fraction of patients with acute ischemic stroke receive intravenous thrombolysis (IVT). We sought to assess barriers and practice patterns in using IVT for among neurologists Saudi Arabia. An electronic survey was sent all registered the Commission Health Specialties. A total 148 (77.5%) responded. The most common reported administration were delayed presentation hospitals (82.4%) unclear time symptom onset (50.0%). 9.9% strict adherence American Heart Association/American...

Presymptomatic genetic testing (PGT) for Alzheimer’s disease (AD) is available at-risk individuals. This study aimed to investigate the public perception of PGT in Saudi Arabia and determine variables that might influence decision undergo PGT. A questionnaire link was posted on Twitter by Disease Association made publicly social media networks. total 2935 people participated, which 59.9% were willing Of these, 26.8% reported having a family history AD, 0.24% had two members with early onset...

<h3>Objectives:</h3> To descriptively assess Epilepsy Monitoring Units (EMUs) and the provided services in Saudi Arabia compare them based on geographic region. <h3>Methods:</h3> In this cross-sectional study, an electronic questionnaire was emailed to all directors of EMUs from July 2013 January 2016, with constant updates being made by respondents throughout period data collection. <h3>Results:</h3> All EMU participated. There were 11 KSA operating 8 hospitals; (54.5%) Riyadh, 2 (18.2%)...

The objective of this study was to administer line bisection (LB) and symbol cancellation (SC) tasks on a sample healthy Arabs in Saudi Arabia, determine if normative performance would differ from that the Western population. A total 136 individuals were enrolled. Deviation direction veridical center percentage deviation scores (PDS) determined for LB. overall SC calculated. Differences according gender, education age measured. Out 2,287 times lines bisected, 1025 (44.82%) deviated rightward...

<h3>Objectives:</h3> To investigate the levels of knowledge and attitudes toward epilepsy surgery among neurologists in Saudi Arabia evaluate factors that affect physicians' attitudes. <h3>Methods:</h3> A quantitative observational cross-sectional study conducted at King Saud University Medical City, Riyadh. The data were collected using a newly developed, self-administered online questionnaire. questionnaire contained 3 sections: demographic information, knowledge, which then sent to...

Objectives: Arabs have a right-to-left language and engage in favoring of the right side or limb when implementing daily routine practices. The purpose this research is to explore effect cultural attitude might on pseudoneglect, by comparing with southeast Asian sample that has left-to-right structure. Methods: Participants were from two separate ethnic groups (Arabs Filipinos), residing Saudi Arabia, healthy individals 18 years above allowed volunteer study. participants recruited at King...

Background: There are few Arabic language functional scales for patients with dementia. The Bristol Activity of Daily Living Scale (BADLS) was designed and validated use in Objective: Our study aimed to translate, cross-culturally adapt, validate the BADLS people neurocognitive decline Methods: original scale translated followed by face validity assessment through a pilot testing five countries. assessed sample 139 participants their caregivers concurrent convergent validity. Results: had...

Weight loss has substantial health benefits, but it is not risk-free. Various neurological disorders have been reported following bariatric surgery-induced weight loss. Here, we report 3 patients who developed multiple sclerosis (MS), one of whom also myasthenia gravis (MG), shortly after significant Two lost by a diet plan and underwent surgery. There may be an association between the development autoimmune disorder such as MS or MG; high index suspicion required.

ABSTRACT Introduction We translated the myasthenia gravis (MG)‐specific activities of daily living (MG‐ADL) scale into Arabic (MG‐ADL‐A) and assessed its psychometric properties. Methods reliability using Cronbach's α, reproducibility intraclass correlation coefficient, validity Spearman's correlations with MG composite (MGC) score, MG‐specific manual muscle test (MG‐MMT), quality‐of‐life revised version (MGQOL15R‐A). Differences in MG‐ADL‐A scores among patients different disease severity...

We aimed to assess the family caregivers' level of knowledge and attitudes about Parkison's disease (PD), identify factors affecting their knowledge, evaluate quality life (QoL) influencing it define effect PD on activities daily living (ADLs) patients.We developed validated a questionnaire caregivers toward PD, effects QoL as well its patients from perspective. A scoring system was utilized SPSS used differences in responses between groups; p < 0.05 indicated statistical significance.69...