A5001114156- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Advancements in Transdermal Drug Delivery
- Analytical Methods in Pharmaceuticals
- Genetic factors in colorectal cancer
- Cancer-related gene regulation
- Lipid Membrane Structure and Behavior
- HER2/EGFR in Cancer Research
- Skin Protection and Aging
- Ferroptosis and cancer prognosis
- Ocular Surface and Contact Lens
- Synthesis and Reactions of Organic Compounds
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Computational Drug Discovery Methods
- Plant-based Medicinal Research
- Antibiotics Pharmacokinetics and Efficacy
- Ethnobotanical and Medicinal Plants Studies
- Bioinformatics and Genomic Networks
- Bee Products Chemical Analysis
- Click Chemistry and Applications
- Cancer Mechanisms and Therapy
- Drug-Induced Hepatotoxicity and Protection
- Tryptophan and brain disorders
- Ocular Infections and Treatments
Riphah International University
2017-2024
The current study explores the potential of melatonin (MLT)-loaded solid lipid nanoparticles (MLT-SLNs) for better neuroprotective effects in ischemic stroke. MLT-SLNs were prepared using matrix palmityl alcohol with a mixture surfactants (Tween 40, Span Myrj 52) stabilizing matrix. tested physical and chemical properties, thermal polymorphic changes, vitro drug release vivo studies rats permanent middle cerebral artery occlusion (p-MCAO) model. optimized showed particle size ∼159 nm, zeta...
Abstract Background Colorectal cancer is known to be the most common type of worldwide with high disease-related mortality. It third in men and women second major cause death globally due cancer. a complicated fatal disease comprising group molecular heterogeneous disorders. Results This study identifies potential biomarkers CRC through differentially expressed analysis, system biology, proteomic analysis. Ten publicly available microarray datasets were analyzed seven identified from list...
The aim of this study was to develop a stable cream from local desert plant capable producing Antisebum effects. Two creams (emulsions) were prepared, both which w/o type. One the formulation in 5% extract obtained plant Capparis decidua was added during preparation and other base or control not while ingredients same as that formulation. Thirteen healthy male volunteers selected their initial sebum readings cheeks noted with help Sebumeter. given asked apply on face daily two times, right...
Abstract This study aims to formulate mucoadhesive vancomycin loaded thiolated chitosan (TCS) nanoparticles. These nanoparticles are and enhance the retention of drug at ocular site. For this purpose, TCS were prepared by ion-gelation method characterized for their size, shape, polydispersity index, mucoadhesion, cellular uptake anti-inflammatory activity. The average size synthesized was found be 288 nm with positive zeta potential. Moreover, 85% successfully encapsulated in using method. A...
Clinical needs for new antifungal agents have gradually and steadily increased with the rise of AIDS-related mycoses, change in spectrum fatal disseminated fungal infections.Triazoles are taken as potential molecules considering existing portfolio available market. This study was aimed to evaluate 4-Amino 5-(2-Hydroxyphenyl)-1,2,4-Triazole-3-Thione and4-(2-hydroxybenzalidine)amine-5-(2-hydroxy)phenyl-1,2,4-triazole-3-thiol using molecular docking in-vitro screening approach. further designed...
The present study is aimed to develop and optimize levosulpiride-loaded nanostructured lipid carriers (LSP-NLCs) for improving oral bioavailability prokinetic activity of LSP. LSP-NLCs were optimized with D-optimal mixture design using solid lipid, liquid surfactant concentrations as independent variables. prepared evaluated physicochemical properties solid-state characterization. in vivo pharmacokinetics rats. formulation was at Precirol® ATO 5/Labrasol (80.55/19.45%, w/w) Tween 80/Span 80...
Flurbiprofen belongs to Biopharmaceutical Classification System (BCS) class II drugs which are poorly soluble in water. The objective of present research work was prepare fast dissolving tablets using varying concentrations three different sublimating agents improve the dissolution rate. Seven formulations were prepared containing camphor, ammonium bicarbonate and thymol as agent along with primogel a superdisintegrant. Tablets manufactured by direct compression method. evaluated for...
Oral absorption is limited for many small-molecule drugs due to their poor aqueous solubility as well as, some, membrane permeation. One such levosulpiride (LSP), used treat psychotic and other conditions. The present study aims explore the effect of nanostructured lipid carriers (NLCs) delivery LSP. permeation LSP in vitro ex vivo effects on epithelium mucosa was monitored. In studies exhibited an 8-fold 1.6-fold increase P
The potential of levosulpiride-loaded nanostructured lipid carriers (LSP-NLCs) for enhanced antidepressant and anxiolytic effects was evaluated in the current study. A forced swim test (FST) tail suspension (TST) were carried out to determine effect whereas activity investigated using light-dark box open field tests. Behavioral changes lipopolysaccharide-induced depressed animals. access LSP brain produce therapeutic estimated qualitatively by fluorescently labeled LSP-NLCs. distribution...
Hydrotropes are the nontoxic small organic molecules that at certain concentrations result in solubility enhancement of poorly water-soluble compounds. In this study various hydrotropes including nicotinamide, sodium acetate and trisodium citrate were used varying ratios to observe effect on Ebastine. Various combinations drug-hydrotrope complexes prepared with each above mentioned using solvent evaporation technique. The resultant residues subjected analytical characterization techniques...
The development of resistance to available anticancer drugs is increasingly becoming a major challenge and new chemical entities could be unveiled compensate for this therapeutic failure.The current study demonstrated whether N-protected deprotected amino acid derivatives 2- aminopyridine attenuate tumor using colorectal cancer cell lines.Biological assays were performed investigate the potential synthesized compounds. in silico ADME profiling docking studies also by designed compounds...