A5100735311- Research on Leishmaniasis Studies
- Orthopedic Surgery and Rehabilitation
- Animal health and immunology
- Neonatal and Maternal Infections
- Trypanosoma species research and implications
- Sepsis Diagnosis and Treatment
- Opioid Use Disorder Treatment
- Streptococcal Infections and Treatments
- Pharmaceutical Practices and Patient Outcomes
- Surgical Sutures and Adhesives
- Pneumocystis jirovecii pneumonia detection and treatment
- Ocular Infections and Treatments
- Actinomycetales infections and treatment
- Neonatal and fetal brain pathology
- Nerve Injury and Rehabilitation
- Medical Imaging and Pathology Studies
- Chemical synthesis and pharmacological studies
- Dupuytren's Contracture and Treatments
- Spondyloarthritis Studies and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Insect and Pesticide Research
- Chemotherapy-related skin toxicity
- Pregnancy and Medication Impact
- Tendon Structure and Treatment
- Hemostasis and retained surgical items
Islamia University of Bahawalpur
2016-2024
Hayatabad Medical Complex
2023
Northwest General Hospital and Research Center
2022
Wrightington Hospital
2014-2020
Sindh Institute of Urology and Transplantation
2010-2020
Wrightington, Wigan and Leigh NHS Foundation Trust
2014
Leeds General Infirmary
2012
Bradford Royal Infirmary
2009
Pinderfields Hospital
2006
Our goal was to improve treatment outcomes for visceral leishmaniasis by designing nanocarriers that drug biodistribution and half-life. Thus, long-acting mannose-anchored thiolated chitosan amphotericin B nanocarrier complexes (MTC AmB) were developed characterized.
Aim: The present study evaluates the efficacy of paromomycin (PM)-loaded mannosylated thiomeric nanoparticles for targeted delivery to pathological organs oral therapy visceral leishmaniasis. Materials & methods: Mannosylated thiolated chitosan (MTC)-coated PM-loaded PLGA (MTC-PLGA-PM) were synthesized and evaluated morphology, drug release, permeation enhancing antileishmanial potential. Results: MTC-PLGA-PM spherical in shape with a size 391.24 ± 6.91 nm an encapsulation efficiency 67.16...
Our aim was to inhibit trypanothione reductase (TR) and P-gp efflux pump of Leishmania by the use thiolated polymers. Thus, increasing intracellular accumulation therapeutic effectiveness antimonial compounds.Mannosylated chitosan mannosylated chitosan-polyethyleneimine graft were synthesized characterized. Meglumine antimoniate-loaded nanoparticles prepared evaluated for TR inhibition, biocompatibility, macrophage uptake antileishmanial potential.Thiomers inhibited with Ki 2.021. The 33.7-...
The aim of this study was to evaluate mannose-anchored thiolated chitosan (MTC) based nanocarriers (NCs) for enhanced permeability, improved oral bioavailability and anti-parasitic potential amphotericin B (AmB). Transgenic Leishmania donovani parasites expressing red fluorescent protein DsRed2 imaging-flow cytometry used investigate parasitic burdens inside bone marrow-derived macrophages ex vivo. Cytokine estimation revealed that MTC activated the impart an explicit immune response by...
Chronic paronychia is a common occupational disease. It multifactorial and affects number of different groups workers. However, the condition not described as affecting hairdressers although hairdressing associated with range other occupation-related hand conditions. We report an unusual case chronic in female hairdresser which occurred consequence hair shaft penetrating beneath nail fold. Personal hygiene thorough removal any hairs that have penetrated epidermis wearing clean gloves can...
Abstract This study aims to formulate mucoadhesive vancomycin loaded thiolated chitosan (TCS) nanoparticles. These nanoparticles are and enhance the retention of drug at ocular site. For this purpose, TCS were prepared by ion-gelation method characterized for their size, shape, polydispersity index, mucoadhesion, cellular uptake anti-inflammatory activity. The average size synthesized was found be 288 nm with positive zeta potential. Moreover, 85% successfully encapsulated in using method. A...
Compartment syndrome is a surgical emergency requiring immediate intervention. Majority of compartment syndromes are associated with trauma or surgery. Spontaneous in multiple limbs rare and alternative diagnosis should be sought. We report young adult man who developed all four sequentially over 4 years. On further evaluation, he was found to have gene mutation exon 3 GYG1 gene. patients does not appear been previously recognised. Although direct causality cannot confidently drawn, this...
Background: Iron deficiency anemia (IDA) and acute gastroenteritis (AGE) are prevalent conditions among children globally, affecting health outcomes significantly. Objective: To determine the association between iron through a cross-sectional study. Material Methods: In this six-month study, total of 180 presenting with symptoms at Al Syed Children Hospital, Mardan, KP, Pakistan were included. Associations IDA various factors analyzed using chi-square tests, significance level set p <...
Nocardia is an opportunistic infection among renal transplant recipients with incidence of <1% but high mortality. Data from Pakistan are scarce. Our aim was to find the risk factors, clinical and radiographic findings, antimicrobial sensitivity, outcomes in Pakistan.
Materials and Methods: A descriptive cross-sectional study was carried out in the pediatrics department at Syed Children Hospital Mardan from April 2022-23. (n=210) newborns who met inclusion criteria were included study. Meningitis verified treated according to hospital practice. Data analyzed through SPSS 26.0. for categorical continues, chai square linear regression used respectively. Results: In a of 210 infants, those with meningitis (n=50) slightly older diagnosis (16.2 ± 5.8 days)...
Sir:FigureThere are many types of core suture; however, until recently, the modified Kessler stitch had been accepted widely as a standard method for repair lacerated tendons. Ideally, flexor tendon should have smooth opposition ends with no bulge and minimal gap between tendons, be sufficiently robust to withstand tension created by mobilization. Over past decade, two-strand has superseded four-strand norm in repair. There number methods performing suture using either one or two knots...
Objective: The present study goal is to determine the frequency of various bacterial organisms in neonatal sepsis and know sensitivity pattern these commonly used antibiotics. Methods: After ethical approval from institutional review board, this descriptive cross-sectional was conducted at Neonatal Intensive Care Unit Medical Teaching Institute, Lady Reading Hospital Peshawar Feb 5, 2020 Aug 4, 2020. Through non-probability consecutive sampling 162 neonates between 1st day 28 days life,...
Objective: Evaluate the effectiveness of Ipratropium Bromide in combination with Salbutamol and alone for treatment recurrent wheezes children asthma who seek care at LRH, Peshawar. Methods: After approval from institution review board, this randomized controlled trial was performed Department Pediatrics, Peshawar, 7th January 2021 to July 2021. A total 128 patients met inclusion criteria were recruited Pediatrics LRH In Group A, 64 given addition Salbutamol, whereas B, alone. group...
Naqvi, S. A.A.1; R.2; Akhtar, S.3; Muzaffar, R.4; F.2; Ahmed, E.2; Rizvi, A.H.1 Author Information