A5025549590- Lung Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- COVID-19 and healthcare impacts
- Atomic and Subatomic Physics Research
- Head and Neck Cancer Studies
- Advances in Oncology and Radiotherapy
- Ultrasound and Hyperthermia Applications
- Sepsis Diagnosis and Treatment
- Medical Image Segmentation Techniques
- Gender Politics and Representation
- Diabetes Management and Education
- Neonatal and Maternal Infections
- Gender, Security, and Conflict
- Skin Diseases and Diabetes
- Infant Nutrition and Health
- Systemic Sclerosis and Related Diseases
- Leaf Properties and Growth Measurement
- Diabetes Management and Research
- Effects of Radiation Exposure
- Brain Metastases and Treatment
- Growth Hormone and Insulin-like Growth Factors
Guy's and St Thomas' NHS Foundation Trust
2005-2023
Guy's Hospital
2023
Hayatabad Medical Complex
2023
Sarda (United States)
2023
Pakistan Institute of Medical Sciences
2022
Baylor College of Medicine
2020-2021
The Royal Free Hospital
2020
University College London
2012-2020
Children's Hospital Colorado
2020
University of Colorado Denver
2020
Respiratory organ motion has a significant impact on the planning and delivery of radiotherapy (RT) treatment for lung cancer. Currently widespread techniques, such as 4D-computed tomography (4DCT), cannot be used to measure variability this from one cycle next. In paper, we describe use fast magnetic resonance imaging (MRI) techniques investigate intra- inter-cycle reproducibility respiratory also estimate level errors that may introduced into by using various breath-hold strategies during...
Respiratory motion can vary dramatically between the planning stage and different fractions of radiotherapy treatment. Motion predictions used when constructing plan may be unsuitable for later This paper presents a methodology patient-specific respiratory models uses these to evaluate analyse inter-fraction variations in motion. The internal is determined from deformable registration Cine CT data related surrogate signal derived 3D skin surface data. Three relating have been investigated...
Cytokines released by infiltrating T cells may promote mechanisms leading to fibrosis in scleroderma. The aim of this study was investigate the role Th2 cytokine IL-31, and its receptor IL-31RA, scleroderma skin lung fibrosis.IL-31 measured ELISA plasma, immunochemistry fibrotic tissue patients. receptor, assayed qPCR resident cells. Next-generation sequencing used profile responses normal fibroblasts IL-31. In wild-type Balb/c mice, IL-31 administered subcutaneous mini pump, with or without...
Background and Aims The etiology of biliary atresia (BA) is not known likely multifactorial, including a genetic predisposition, viral or environmental trigger, an aberrant autoimmune response targeting cholangiocytes, unique susceptibilities the neonatal bile ducts to injury. Damaged cholangiocytes may express neo self‐antigens elicit autoreactive T‐cell‐mediated inflammation B‐cell production autoantibodies. aim this study was discover autoantibodies in BA that correlated with outcomes....
Agriculture production is extremely important in today’s economy because disease development plants relatively common, early detection of critical the agriculture field. The automatic finding such early-stage helpful as it decreases a great effort supervising large farmhouses yields. Using digital image processing and machine learning algorithms, this paper presents method for detecting plant disease. done on yields’ various leaves. presented system simple computationally efficient which...
AimsIn response to the COVID-19 pandemic, guidelines on reduced fractionation for patients treated with curative-intent radiotherapy were published, aimed at reducing number of hospital attendances and potential exposure vulnerable minimise risk infection. We describe changes that took place in management stage I–III lung cancer from April October 2020.Materials methodsLung Radiotherapy during Pandemic (COVID-RT Lung) is a prospective multicentre UK cohort study. The inclusion criteria were:...
Respiratory motion causes problems of tumour localisation in radiotherapy treatment planning for lung cancer patients. We have developed a novel method building patient specific models, which model the movement and non-rigid deformation surrounding tissue over respiratory cycle. Free-breathing (FB) CT scans are acquired cine mode, using 3 couch positions to acquire contiguous 'slabs' 16 slices covering region interest. For each slab, 20 FB volumes approx 20s. A reference volume at Breath...
Purpose: To remove artefacts that occur between adjacent couch positions in 4DCT volumes acquired Cine mode. Method and Materials: separate B-spline non-rigid registration is performed an artefact free reference volume the data from each individual position volume. The using extended control point grid covers all of common to registrations. Therefore result defines a transformation over but was only constrained by one position. results are then combined into single transformation....
We propose a method to build fully deformable motion model directly from cone-beam CT (CBCT) projections. This allows inter-fraction variations in the respiratory be accounted for. It is envisaged that used track tumour, and monitor organs at risk (OAR), during gated or tracked radiotherapy (RT) treatment of lung cancer. The tested on CBCT projections simulated phantom two cases. simulations are generated patient trace associated scanner geometry. Without with correction, l2 norm maximum...
Previous work found that during the first wave of COVID-19 pandemic, 34% patients with lung cancer treated curative-intent radiotherapy in UK had a change to their centre's usual standard care treatment (Banfill et al. Clin Oncol 2022;34:19-27). We present impact these changes on patient outcomes.The COVID-RT Lung database was prospective multicentre cohort study including stage I-III referred for and/or radical between April and October 2020. Data were collected demographics, systemic...
18032 Background: The addition of cetuximab can increase the efficacy chemotherapy for advanced NSCLC. Concomitant and RT is superior to alone locally squamous cell head & neck carcinoma. SCRATCH study (cohort I) a phase I assess safety synchronous radical in patients with Stage III Methods: Cohort will contain 12 inoperable stage Inclusion criteria are performance status 0–1, adequate organ function, disease encompassable within volume. Exclusion previous malignancy, thoracic or...
Abstract Background: Ectopic Cushing’s Syndrome is a rare but often aggressive condition caused by ACTH-hypersecretion from non-pituitary tumors. In patients with metastatic cancer, as well those occult tumors, the diagnosis and management can be extremely challenging. Clinical Case: A 25-year old woman recently diagnosed poorly differentiated liver carcinoma of unknown primary was admitted for lower extremity edema worsening fatigue preceding month. Since being she developed uncontrolled...
Serum Lactate as a predictor of in-hospital mortality in patients with sepsis
Purpose: To investigate quantitatively variations in CT number distributions of mobile targets cone‐beam (CBCT) imaging. A mathematical model was developed to predict the and their dependence on motion parameters targets. Materials Methods: CBCT images were acquired for three manufactured from homogenous water‐equivalent gel inserted into a commercial thorax phantom. The phantom moved with controlled cyclic patterns one‐dimension along superior‐inferior direction simulate patient respiratory...