A5073996406- Advanced Radiotherapy Techniques
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Meningioma and schwannoma management
- Radiopharmaceutical Chemistry and Applications
- Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Cancer, Hypoxia, and Metabolism
- Radiation Therapy and Dosimetry
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Cancer Treatment and Pharmacology
- Management of metastatic bone disease
- Nutrition and Health in Aging
- Radiation Dose and Imaging
- Salivary Gland Tumors Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
Universitätsklinikum Würzburg
2017-2024
University of Würzburg
2017-2023
Klinik und Poliklinik für Strahlentherapie und Radioonkologie
2019-2022
European Neuroendocrine Tumor Society
2021
University of Rostock
2013
The intent of this pooled analysis as part the German society for radiation oncology (DEGRO) stereotactic body radiotherapy (SBRT) initiative was to analyze patterns care SBRT liver oligometastases and derive factors influencing treated metastases control overall survival in a large patient cohort. From 17 Swiss centers, data on all patients with since its introduction 1997 has been collected entered into centralized database. In addition tumor characteristics, immobilization, image guidance...
The aim of this analysis was to model the effect local control (LC) on overall survival (OS) in patients treated with stereotactic body radiotherapy (SBRT) for liver or lung metastases from colorectal cancer.The is based pooled data two retrospective SBRT databases pulmonary and hepatic 27 centers Germany Switzerland. Only cancer were considered avoid histology as a confounding factor. An illness-death employed relationship between LC OS.Three hundred eighty-eight 500 metastatic lesions...
BACKGROUND In patients with head and neck esophageal tumors, nutritional status may deteriorate during concurrent chemoradiotherapy (CRT). The aim of this study was to investigate the influence enteral nutrition enriched eicosapentaenoic acid (EPA) docosahexaenoic (DHA) on body composition functional status. METHODS a controlled, randomized, prospective, double‐blind, multicenter study, 111 cancer undergoing CRT received either an standard (control group) or disease‐specific Supportan ®...
Importance The number of older adults with head and neck squamous cell carcinoma (HNSCC) is increasing, these patients are underrepresented in clinical trials. It unclear whether the addition chemotherapy or cetuximab to radiotherapy associated improved survival HNSCC. Objective To examine definitive locoregionally advanced (LA) Design, Setting, Participants Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy (SENIOR) study an international, multicenter cohort including...
Despite of a multimodal approach, recurrences can hardly be prevented in glioblastoma. This may part due to so called glioma stem cells. However, there is no established marker identify these cells.Paired samples from patients were analyzed by immunohistochemistry for expression the following cell markers: CD133, Musashi, Nanog, Nestin, octamer-binding transcription factor 4 (Oct4), and sex determining region Y-box 2 (Sox2). In addition, osteopontin (OPN) was investigated. The relative...
Abstract Purpose Several studies have demonstrated the negative impact of radiotherapy protocol deviations on tumor control in medulloblastoma. In SIOP PNET5 MB trial, a pretreatment quality (RT-QC) program was introduced. A first analysis for patients enrolled Germany, Switzerland and Austria with focus types initial plan proposals review criteria modern radiation technologies performed. Methods Sixty-nine craniospinal irradiation (CSI) plans were available detailed analyses. RT-QC...
Abstract This retrospective, single-institutional study investigated long-term outcome, toxicity and health-related quality of life (HRQoL) in meningioma patients after radiotherapy. We analyzed the data 119 who received radiotherapy at our department from 1997 to 2014 for intracranial WHO grade I-III meningioma. Fractionated stereotactic (FSRT), intensity modulated (IMRT) or radiosurgery radiation was applied. The EORTC QLQ-C30 QLQ-BN20 questionnaires were completed assessment HRQoL....
Cumulative cisplatin doses of ≥ 200 mg/m2 improve survival in adults with head-and-neck squamous cell carcinoma (HNSCC) undergoing chemoradiation, but many older HNSCC cannot receive this prognostically relevant dose due to toxicities. This study aims develop predictive models assess the likelihood receiving during chemoradiation. 366 patients from SENIOR database, an international cohort 65 years HNSCC, received definitive chemoradiation single-agent and were analyzed. A Generalized Linear...
We describe the case of a 71-year-old Caucasian female with primary disseminated non-small cell cancer lung, presented for palliative radiotherapy metastatic spread to 9th and 11th thoracic vertebrae without intramedullary growth. Palliative daily fractions 3 Gy cumulative dose 36 8-12 was performed. The patient received concomitantly 250 mg gefitinib daily. After latent period 16 months, developed symptoms myelitis. Magnetic resonance imaging (MRI) did not reveal any bony or intraspinal...
Abstract Background Current standard of treatment for newly diagnosed patients with glioblastoma (GBM) is surgical resection adjuvant normofractionated radiotherapy (NFRT) combined temozolomide (TMZ) chemotherapy. Hyperfractionated accelerated (HFRT) which was known as an option from randomized controlled trials before the era has not been compared to therapy in a setting TMZ. Methods Data 152 GBM treated 10/2004 until 7/2018 at single tertiary care institution were extracted clinical...
<b><i>Purpose:</i></b> The aim of our study was the external validation an extended variant four-tiered diagnosis-specific graded prognostic assessment (DS-GPA) that includes more information about extracranial disease burden and blood test results, predicts survival patients with brain metastases. DS-GPA (EC-GPA) serum albumin, lactate dehydrogenase, number organs involved. Originally, score developed in Germany. <b><i>Patients...
The number of older adults with head and neck squamous cell carcinoma (HNSCC) is increasing, treatment these patients challenging. Although cisplatin-based chemotherapy concomitantly radiation therapy considered the standard regimen for locoregionally advanced HNSCC, there substantial real-world heterogeneity regarding concomitant in HNSCC.
In Germany, Austria, and Switzerland, pretreatment radiotherapy quality control (RT-QC) for tumor bed boost (TB) in non-metastatic medulloblastoma (MB) was not mandatory but recommended patients enrolled the SIOP PNET5 MB trial between 2014 2018. This individual case review (ICR) analysis aimed to evaluate types of deviations initial plan proposals develop uniform criteria TB boost.A total 78 were registered this trial, whom a subgroup 65 available evaluation treatment plans. Dose uniformity...
Most of the patients with head and neck squamous cell carcinoma (HNSCC) are diagnosed locally advanced disease. Standards care for curative-intent treatment this patient group either surgery adjuvant radio(chemo)therapy (aRCT) or definitive chemoradiation. Despite these treatments, especially pathologically intermediate high-risk HNSCC often recur. The ADRISK trial investigates in high risk after up-front if addition pembrolizumab to aRCT cisplatin improves event-free sur-vival compared...
Boluses are routinely used in radiotherapy to modify surface doses. Nevertheless, considerable dose discrepancies may occur some cases due fit inaccuracy of commercially available standard flat boluses. Moreover, the simple geometric design conventional boluses, also surrounding healthy skin areas be unintentionally covered, resulting unwanted buildup. With fused deposition modeling (FDM) technique, there is a and possibly cost-effective way solve these problems routine clinical practice....