A5036442108- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Medical Imaging Techniques and Applications
- Breast Cancer Treatment Studies
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Radiation Therapy and Dosimetry
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Breast Lesions and Carcinomas
- Advanced X-ray and CT Imaging
- Cancer Treatment and Pharmacology
- Advanced MRI Techniques and Applications
- Bone and Dental Protein Studies
- Colorectal Cancer Treatments and Studies
- DNA Repair Mechanisms
- Breast Implant and Reconstruction
- Bladder and Urothelial Cancer Treatments
- Lung Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
- PI3K/AKT/mTOR signaling in cancer
- Radiopharmaceutical Chemistry and Applications
- Meningioma and schwannoma management
University of Würzburg
2015-2025
Universitätsklinikum Würzburg
2016-2025
Klinik und Poliklinik für Strahlentherapie und Radioonkologie
2009-2025
Inonu University
2024
Teknoloji Arastirma ve Gelistirme Endustriyel Urunler Bilisim Teknolojileri San Tic
2022
Ondokuz Mayıs University
2022
Ankara Sosyal Bilimler Üniversitesi
2022
Comprehensive Cancer Center Mainfranken
2014-2021
European Neuroendocrine Tumor Society
2014-2021
Atatürk University
2020
Total neoadjuvant therapy is a new paradigm for rectal cancer treatment. Optimal scheduling of preoperative chemoradiotherapy (CRT) and chemotherapy remains to be established. We conducted multicenter, randomized, phase II trial using pick-the-winner design on the basis hypothesis an increased pathologic complete response (pCR) 25% after total compared with standard 15% CRT. Patients stage or III were assigned group A induction three cycles fluorouracil, leucovorin, oxaliplatin before...
Total neoadjuvant therapy has been increasingly adopted for multimodal rectal cancer treatment. The optimal sequence of chemoradiotherapy (CRT) and chemotherapy needs to be established. To report the long-term results secondary end points prespecified in Randomized Phase 2 Trial Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Neoadjuvant Therapy (CAO/ARO/AIO-12 trial) Locally Advanced Rectal Cancer. This analysis a randomized clinical trial included 311 patients who were...
Investigating the value of Ga-PSMA-PET/CT in biochemically recurring prostate cancer patients with negative F-choline-PET/CT.One hundred thirty-nine consecutive biochemical recurrence after curative (surgery and/or radiotherapy) therapy were offered participation this sequential clinical imaging approach. Patients first underwent an F-choline-PET/CT. If negative, additional was offered. One twenty-five 139 eligible included study; 32 Ga-PSMA-PET/CT. equivocal findings (n = 5) on...
Local tumor recurrence is common in adrenocortical carcinoma (ACC) and the most frequent cause for reoperation. Although radiotherapy often considered ineffective treatment of ACC, limited number available studies does not support this statement.The objective study was investigation adjuvant bed irradiation ACC.We performed a retrospective analysis.The German ACC Registry (n = 285) screened patients who had received an setting (no macroscopic evidence residual disease after surgery)....
Aim: We report results of a first-in-human study pasotuxizumab, PSMA bispecific T-cell engager (BiTE R ) immune therapy mediating killing tumor cells in patients with advanced castrationresistant prostate cancer.Patients & methods: assessed once-daily subcutaneous (SC) pasotuxizumab.All SC developed antidrug antibodies; therefore, continuous intravenous (cIV) infusion was assessed.Results: A total 47 received pasotuxizumab (SC: n = 31, 0.5-172 μg/d; cIV: 16, 5-80 μg/d).The maximum tolerated...
•Decipher identifies patients at highest risk of progression who may require treatment intensification.•Decipher defines subgroups associated with improved outcomes when treated very early SRT compared late SRT.•Transcriptomic profiling can guide personalized management timing and the addition systemic therapy. BackgroundThe Decipher genomic classifier (GC) has shown to independently prognosticate in prostate cancer. The objective this study was validate GC a randomized phase III trial...
İnsanlık tarihi boyunca, insan ve doğa arasındaki ilişki değişime uğramıştır. Toplayıcı ilk insandan günümüze iklim binlerce yıl boyunca yaşamını şekillendirmiştir. Ancak son yüzyıllarda bu durum ağırlıklı olarak değişmeye başlamıştır. İnsan kaynaklı fosil yakıtlar, ormansızlaşma, arazi kullanımı, sanayi süreçleri sera gazı salınımı gibi etkilerle küresel çapta değişiklikleri yaşanmaya başlamış önümüzdeki yıllarda da etkilerinin boyutlarının daha büyüyeceği öngörülmektedir. İklim biliminin...
Adaptive Radiotherapy aims to identify anatomical deviations during a radiotherapy course and modify the treatment plan maintain objectives. This requires regions of interest (ROIs) be defined using most recent imaging data. study investigates clinical utility deformable image registration (DIR) automatically propagate ROIs. Target (GTV) organ-at-risk (OAR) ROIs were non-rigidly propagated from planning CT scan per-treatment for 22 patients. Propagated quantitatively compared with expert...
Abstract International guidelines emphasise the role of local therapies (LT) for treatment advanced adrenocortical carcinoma (ACC). However, large studies are lacking in this field. Therefore, we performed a review literature to synthesise current evidence and develop clinical guidance. PubMed database was searched systematic literature. We identified 119 potentially relevant articles, which 21 could be included our final analysis. All were retrospective reported on 374 patients treated with...
High expression of constitutive histone γ-H2AX, a sensitive marker DNA damage, might be indicative defective repair pathway or genomic instability. 53BP1 (p53-binding protein 1) is conserved checkpoint with properties double-strand breaks sensor. This study explores the relationship between clinical radiosensitivity tumor patients and expression/induction γ-H2AX in vitro. Using immunostaining, we assessed spontaneous radiation-induced foci 53 BP1 peripheral blood mononuclear cells derived...
Previous studies have shown that the dual phosphatidylinositide 3-kinase/mammalian target of rapamycin (PI3K/mTOR) inhibitor NVP-BEZ235 radiosensitizes tumor cells if added shortly before ionizing radiation (IR) and kept in culture medium thereafter. The present study explores impact IR schedule on radiosensitizing ability four human glioblastoma cell lines. Two different drug-IR treatment schedules were compared. In I, treated with for 24 hours drug was removed IR. II, exposed to 1 hour...