A5090066209- Head and Neck Cancer Studies
- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Management of metastatic bone disease
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Mesenchymal stem cell research
- Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Effects of Radiation Exposure
- Prostate Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Gastric Cancer Management and Outcomes
- Head and Neck Surgical Oncology
- Glioma Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Lung Cancer Research Studies
- Brain Metastases and Treatment
- Prostate Cancer Treatment and Research
- Cancer survivorship and care
- Radiation Therapy and Dosimetry
- Cancer Immunotherapy and Biomarkers
- Oral health in cancer treatment
- MRI in cancer diagnosis
University of Freiburg
2018-2025
German Cancer Research Center
2016-2025
University Hospital Leipzig
2023-2025
Heidelberg University
2016-2025
University Hospital Heidelberg
2012-2025
Leipzig University
2022-2025
University Medical Center Freiburg
2017-2024
Deutschen Konsortium für Translationale Krebsforschung
2019-2024
Klinik und Poliklinik für Strahlentherapie und Radioonkologie
2023-2024
German Marine Research Consortium
2020-2023
BackgroundTo report the primary endpoint of a randomized trial comparing pain response following palliative stereotactic body radiation therapy (SBRT) versus conventionally-fractionated 3D-conformal radiotherapy (3DCRT) for previously untreated spinal metastases.MethodsFifty-five patients with histologically/radiologically confirmed painful metastases were analyzed in this single-institutional, non-blinded, explorative trial. Participants randomly assigned (1:1) to receive single-fraction...
Radiotherapy is a mainstay for the treatment of lung cancer that can induce pneumonitis or pulmonary fibrosis. The matricellular protein connective tissue growth factor (CTGF) central mediator remodeling. A radiation-induced mouse model fibrosis was used to determine if transient administration human antibody CTGF (FG-3019) started at different times before after 20 Gy thoracic irradiation reduced acute and chronic radiation toxicity. Mice (25 mice/group; 10 mice/group in confirmation study)...
Background: Radiotherapy (RT) is a mainstay for the treatment of lung cancer, but effective dose often limited by development radiation-induced pneumonitis and pulmonary fibrosis. Transforming growth factor β (TGFβ) platelet-derived (PDGF) play crucial roles in these diseases, effects dual inhibition on fibrosis remain unclear. Methods: C57BL/6 mice were treated with 20 Gy to thorax induce PDGF receptor inhibitors SU9518 SU14816 (imatinib) TGFβ inhibitor galunisertib applied individually or...
We investigated the clinical outcome and toxicity of trimodal therapy malignant pleural mesothelioma (MPM) treated with neoadjuvant chemotherapy, extrapleural pneumonectomy (EPP) adjuvant intensity-modulated radiotherapy (IMRT). Chemotherapy regimens included Cisplatin/Pemetrexed, Carboplatin/Pemetrexed Cisplatin/Gemcitabine, followed by EPP. 62 patients completed radiotherapy. IMRT was carried out in two techniques, either step&shoot or helical tomotherapy. Median target dose 48 Gy to 54...
Abstract Background Head-and-neck squamous cell carcinoma (HNSCC) is one of the most common malignancies globally, and number elderly patients diagnosed with HNSCC increasing. However, as are underrepresented in clinical trials, current decision making for this cohort largely lacks evidence. Methods Elderly (≥65 years) undergoing (chemo)radiotherapy from 2010 to 2018 at Freiburg University Medical Center were assessed patterns care, locoregional control (LRC), progression-free (PFS) overall...
To report our experience with increased dose intensity-modulated radiation and concurrent systemic chemotherapy as definitive treatment of locally advanced esophageal cancer. We analyzed 27 consecutive patients histologically proven cancer, who were treated increased-dose IMRT part their therapy. The majority had T3/4 and/or N1 disease (93%). Squamous cell carcinoma was the dominating histology (81%). delivered in step-and-shoot technique all using an integrated boost concept. volume covered...
Abstract Mesenchymal stem cells (MSCs) have been shown to attenuate pulmonary damage induced by bleomycin-based anticancer treatments, but the influence of bleomycin on themselves remains largely unknown. Here, we demonstrate that human bone marrow-derived MSCs are relatively sensitive exposure compared adult fibroblasts. revealed increased levels apoptosis after treatment, while cellular morphology, cell surface marker expression and ability for adhesion migration remained unchanged....
Accurate delineation of the intraprostatic gross tumor volume (GTV) is a prerequisite for treatment approaches in patients with primary prostate cancer (PCa). Prostate-specific membrane antigen PET (PSMA PET) may outperform MRI GTV detection. However, visual underlies interobserver heterogeneity and time consuming. The aim this study was to develop convolutional neural network (CNN) automated segmentation (GTV-CNN) PSMA PET. Methods: CNN (3D U-Net) trained on 68Ga-PSMA images 152 from 2...
Abstract Purpose Accurate delineation of intraprostatic gross tumor volume (GTV) is mandatory for successful fusion biopsy guidance and focal therapy planning prostate cancer (PCa). Multiparametric magnetic resonance imaging (mpMRI) the current gold standard GTV delineation; however, prostate-specific membrane antigen positron emission tomography (PSMA-PET) emerging as a promising alternative. This study compares between mpMRI 68 Ga-PSMA-PET in large number patients using validated...
Tumor hypoxia is associated with radiation resistance and can be longitudinally monitored by 18F-fluoromisonidazole (18F-FMISO)-PET/CT. Our study aimed at evaluating radiomics dynamics of 18F-FMISO-hypoxia imaging during chemo-radiotherapy (CRT) as predictors for treatment outcome in head-and-neck squamous cell carcinoma (HNSCC) patients. We prospectively recruited 35 HNSCC patients undergoing definitive CRT longitudinal 18F-FMISO-PET/CT scans weeks 0, 2 5 (W0/W2/W5). Patients were...
Financial toxicity arises in cancer patients from subjective financial distress due to objective burden the disease or treatment. associates with worse outcomes. It has not been described undergoing radiotherapy Germany and its publicly funded health system. In this context, we therefore investigated prevalence of toxicity, associated risk factors, patient preferences on communication burden.We conducted a preregistered ( https://doi.org/10.17605/OSF.IO/KH6VX ) cross-sectional study...
Abstract We performed a prospective study of circulating immune cell changes after stereotactic body radiotherapy (SBRT) in 50 early-stage NSCLC patients. found no significant increase CD8 + cytotoxic T lymphocytes at first follow-up (the primary endpoint) but detected expanding Ki-67 and CD4 T-cell fractions patients treated with 10 Gy or less per fraction. SBRT can induce expansion effector T-cells immediately post-treatment.
Importance The number of older adults with head and neck squamous cell carcinoma (HNSCC) is increasing, these patients are underrepresented in clinical trials. It unclear whether the addition chemotherapy or cetuximab to radiotherapy associated improved survival HNSCC. Objective To examine definitive locoregionally advanced (LA) Design, Setting, Participants Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy (SENIOR) study an international, multicenter cohort including...
The purpose of this clinical study is to investigate the feasibility and safety a shuttle-based MR-linac connection provide MR-guided radiotherapy.A total 40 patients with an indication for neoadjuvant, adjuvant or definitive radiation treatment will be recruited including tumors head neck region, thorax, upper gastrointestinal tract pelvic region. All receive standard therapy, i.e. highly conformal techniques like CT-guided intensity-modulated radiotherapy (IMRT) without concomitant...
Mesenchymal stem cells (MSCs) are an integral part of the bone marrow niche and aid in protection, regeneration proliferation hematopoietic after exposure to myelotoxic taxane anti-cancer agents, but influence compounds on MSCs themselves remains incompletely understood. Here, we show that marrow-derived highly sensitive even low concentrations prototypical compound paclitaxel. While remained metabolically viable, they were strongly impaired regarding both their functional capabilities...
Carbon ion radiation is a promising new form of radiotherapy for cancer, but the central question about biologic effects charged particle yet incompletely understood. Key to this understanding interaction ions with DNA in cell's nucleus. Induction and repair lesions including double-strand breaks (DSBs) are decisive cell. Several DSB markers have been used investigate these processes microscopically, limited resolution conventional microscopy insufficient provide structural insights. We...