A5089050618- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Prostate Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Radiation Therapy and Dosimetry
- Advanced X-ray and CT Imaging
- Prostate Cancer Treatment and Research
- Radiation Dose and Imaging
- Lung Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Brain Metastases and Treatment
- Breast Cancer Treatment Studies
- Cancer, Hypoxia, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Surgical Treatments
- Advanced MRI Techniques and Applications
- Photoacoustic and Ultrasonic Imaging
- Medical Image Segmentation Techniques
- MRI in cancer diagnosis
- Medical Imaging and Analysis
- Advances in Oncology and Radiotherapy
- Ultrasound and Hyperthermia Applications
- Advanced Multi-Objective Optimization Algorithms
- Management of metastatic bone disease
University Medical Center Freiburg
2016-2025
University of Freiburg
2016-2025
German Cancer Research Center
2016-2025
Deutschen Konsortium für Translationale Krebsforschung
2016-2025
Heidelberg University
1989-2024
University Medical Center
2020
Woodward (United States)
2020
Ferrer Grupo (Spain)
2020
Economic History Society
2020
Amsterdam UMC Location University of Amsterdam
2018
Purpose: To evaluate the performance of radiomic features (RF) derived from PSMA PET for intraprostatic tumor discrimination and non-invasive characterization Gleason score (GS) pelvic lymph node status.Patients methods: Patients with prostate cancer (PCa) who underwent [ 68 Ga]-PSMA-11 PET/CT followed by radical prostatectomy dissection were prospectively enrolled (n=20).Coregistered histopathological gross volume (GTV-Histo) in served as reference.133 RF GTV-Histo manually created...
Deformable image registration is a very important field of research in medical imaging. Recently multiple deep learning approaches were published this area showing promising results. However, drawbacks methods are the need for large amount training datasets and their inability to register unseen images different from datasets. One shot comes without has already been proven be applicable 3D data. In work we present one approach periodic motion tracking 4D When applied dataset algorithm...
Purpose Precise delineation of organs at risk is a crucial task in radiotherapy treatment planning for delivering high doses to the tumor while sparing healthy tissues. In recent years, automated segmentation methods have shown an increasingly performance various anatomical structures. However, this remains challenging like esophagus, which versatile shape and poor contrast neighboring For human experts, segmenting esophagus from CT images time‐consuming error‐prone process. To tackle these...
Focal radiation therapy has gained of interest in treatment patients with primary prostate cancer (PCa). The question how to define the intraprostatic boost volume is still open. Previous studies showed that multiparametric MRI (mpMRI) or PSMA PET alone could be used for definition. However, other proposed combined usage both highest sensitivity detection lesions. aim this study was demonstrate feasibility and evaluate tumour control probability (TCP) normal tissue complication (NTCP) dose...
A multiobjective gradient-based algorithm has been developed for the purpose of dose distribution optimization in external beam conformal radiotherapy. This is based on concept gathering values all objectives into a single value. The weighting factors composite objective are varied different steps, allowing reconstruction trade-off surfaces (three or more objectives) curves (two which define boundary between feasible and non-feasible domain regions. analysis these allows decision-maker to...
A new microSelectron pulsed dose rate source has been designed, containing two active pellets instead of one inactive and pellet contained in the old design, to facilitate incorporation higher activity up 74 GBq (2 Ci). In this work, Monte Carlo simulation is used derive full dosimetric data following AAPM TG-43 formalism, as well per unit air kerma strength Cartesian, "away along" coordinates for both designs. The calculated constant PDR design was found equal lambda=(1.121 +/- 0.006) cGy...
We propose a hybrid multiobjective (MO) evolutionary optimization algorithm (MOEA) for intensity-modulated radiotherapy inverse planning and apply it to optimize the number of incident beams, their orientations intensity profiles. The produces set efficient solutions, which represent different clinical trade-offs contains information such as variety dose distributions dose–volume histograms. No importance factors are required solutions can be obtained in regions not accessible by...
Stereotactic radiotherapy near serial organs at risk (OAR) requires special caution. A novel intensity-modulated (IMRT) prescription concept termed simultaneous integrated protection (SIP) for quantifiable and comparable dose to targets very close OAR is described. An intersection volume of a planning (PRV) with the total target (PTV) defined (PTVSIP). The remainder PTV represented dominant (PTVdom). Planning was performed using IMRT. Dose prescribed PTVdom according ICRU in 3, 5, 8, or 12...
Accurate delineation of the intraprostatic gross tumor volume (GTV) is a prerequisite for treatment approaches in patients with primary prostate cancer (PCa). Prostate-specific membrane antigen PET (PSMA PET) may outperform MRI GTV detection. However, visual underlies interobserver heterogeneity and time consuming. The aim this study was to develop convolutional neural network (CNN) automated segmentation (GTV-CNN) PSMA PET. Methods: CNN (3D U-Net) trained on 68Ga-PSMA images 152 from 2...
PurposeThe bicentric HypoFocal phase 2 trial investigates the implementation of molecular imaging with positron-emission tomography targeting prostate-specific membrane antigen (PSMA-PET) into modern focal dose-escalation radiation therapy (RT) concepts in nonrandomized arms. We present planned safety analysis after 6 months follow-up.Materials and MethodsIntermediate- high-risk localized primary prostate cancer patients staged multiparametric magnet resonance PSMA-PET were either treated...
Prostate cancer (PCa) is the most frequent diagnosed malignancy in male patients Europe and radiation therapy (RT) a main treatment option. However, current RT concepts for PCa have an imminent need to be rectified order modify radiotherapeutic strategy by considering (i) personal biology terms of radio resistance (ii) individual preferences each patient. To this end, mechanistic multiscale model prostate tumor response external schemes, based on discrete entity event simulation approach has...
We consider the behaviour of limited memory L-BFGS algorithm as a representative constraint-free gradient-based which is used for multiobjective (MO) dose optimization intensity modulated radiotherapy (IMRT). Using parameter transformation, positivity constraint problem negative beam fluences entirely eliminated: feature to date has not been fully understood by all investigators. analyse global convergence properties searching existence and influence possible local minima. With fast...
Tumor hypoxia is associated with radiation resistance and can be longitudinally monitored by 18F-fluoromisonidazole (18F-FMISO)-PET/CT. Our study aimed at evaluating radiomics dynamics of 18F-FMISO-hypoxia imaging during chemo-radiotherapy (CRT) as predictors for treatment outcome in head-and-neck squamous cell carcinoma (HNSCC) patients. We prospectively recruited 35 HNSCC patients undergoing definitive CRT longitudinal 18F-FMISO-PET/CT scans weeks 0, 2 5 (W0/W2/W5). Patients were...
Abstract Purpose The value of O-(2-[18F]fluoroethyl)-L-tyrosine (FET)-positron emission tomography (PET)-radiomics in the outcome assessment patients with recurrent glioblastoma (rGBM) has not been evaluated until now. aim this study was to evaluate whether a prognostic model based on FET-PET radiomics features (RF) is feasible and can identify rGBM that would most benefit from re-irradiation. Methods We prospectively recruited who underwent before re-irradiation (GLIAA-Pilot trial,...
Technical advances in radiotherapy (RT) treatment planning and delivery have substantially changed RT concepts for primary prostate cancer (PCa) by (i) enabling a reduction of time, (ii) safe high doses. Several studies proposed dose-response relationship patients with PCa especially high-risk features, as dose escalation leads to improved tumor control. In parallel the improvements techniques, diagnostic imaging techniques like multiparametric magnetic resonance (mpMRI) positron-emission...
The aim of this study is to identify clinically relevant image feature (IF) changes during chemoradiation and evaluate their efficacy in predicting treatment response. Patients with non-small-cell lung cancer (NSCLC) were enrolled two prospective trials (STRIPE, PET-Plan). We evaluated 48 patients who underwent static (3D) retrospectively-respiratory-gated 4D PET/CT scans before a 3D scan or after treatment. Our proposed method rejects IF due intrinsic variability. variability observed...