A5026861429- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Nuclear Physics and Applications
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Advances in Oncology and Radiotherapy
- Radiation Detection and Scintillator Technologies
- Lung Cancer Diagnosis and Treatment
- Digital Radiography and Breast Imaging
- Breast Cancer Treatment Studies
- Cancer Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Body Composition Measurement Techniques
- Management of metastatic bone disease
- Machine Learning and Data Classification
- Head and Neck Cancer Studies
- Biomedical Text Mining and Ontologies
- Cancer survivorship and care
- Nuclear reactor physics and engineering
University Medical Center Freiburg
2013-2024
German Cancer Research Center
2017-2024
University of Freiburg
2018-2024
Heidelberg University
2018-2024
Deutschen Konsortium für Translationale Krebsforschung
2017-2023
Centrum Wiskunde & Informatica
2018
Azienda Ospedaliero Universitaria Ospedali Riuniti
2015
Universitätsklinik für Strahlentherapie
2015
University of Würzburg
2009-2012
Klinik und Poliklinik für Strahlentherapie und Radioonkologie
2009
PurposeThe bicentric HypoFocal phase 2 trial investigates the implementation of molecular imaging with positron-emission tomography targeting prostate-specific membrane antigen (PSMA-PET) into modern focal dose-escalation radiation therapy (RT) concepts in nonrandomized arms. We present planned safety analysis after 6 months follow-up.Materials and MethodsIntermediate- high-risk localized primary prostate cancer patients staged multiparametric magnet resonance PSMA-PET were either treated...
ICRU 50/62 provides a framework to facilitate the reporting of external beam radiotherapy treatments from different institutions. A predominant role is played by points that represent "the PTV dose". However, for new techniques like Intensity Modulated Radiotherapy (IMRT) - especially step and shoot IMRT it difficult define point whose dose can be called "characteristic" distribution. Therefore volume based methods prescribed are in use worldwide. Several them were compared regarding their...
The purpose of this work is to develop fast deliverable step and shoot IMRT technique. A reduction in the number segments should theoretically be possible, whilst simultaneously maintaining plan quality, provided that accompanied by an increased gantry angles. benefit method segment shaping could performed during motion, thereby reducing delivery time. aim was find classes such solutions whose quality can compete with conventional IMRT.A planning study performed. Step plans were created...
There are currently no data from randomized controlled trials on the use of intraoperative radiotherapy (IORT) as a tumor bed boost part breast-conservation approach for breast cancer. This study retrospectively reviewed safety and efficacy IORT treatment at tertiary cancer center.From 2015 to 2019, patients underwent breast-conserving surgery with axillary lymph node staging single dose 20 Gy 50-kV photons, followed by whole-breast irradiation (WBI) adjuvant systemic therapy (if...
Every day a large amount of data is produced within radiotherapy department. Although this available in one form or other the centralised systems, it often not which interest to departmental staff. This work presents flexible browser based reporting and visualization system for clinical scientific use, currently found commercially software such as MOSAIQ(TM) ARIA(TM). Moreover, majority user merely wish retrieve record and/or modify data. Thus idea was conceived, present with all relevant...
Purpose: Single or few arc intensity‐modulated therapy (IMAT) is intended to be a time saving irradiation method, potentially replacing classical radiotherapy (IMRT). The aim of this work was evaluate the quality different IMAT methods with potential fast delivery, which also has possibility adapting daily shape target volume. Methods: A planning study performed. Novel double and triple techniques based on geometrical analysis organ at risk geometry (2‐step IMAT) were evaluated. They...
Positron emission tomography and multiparametric MRI provide crucial information concerning tumor extent normal tissue anatomy. Moreover, they are able to visualize biological characteristics of the tumor, which can be considered in radiation treatment planning monitoring. In this review we discuss impact imaging positron for oncology, based on data literature experience our own institution field.
Purpose: For fast adaptation of step and shoot intensity modulated radiotherapy (IMRT) plans, monitor units (MU)-preserving methods which modify only the segment shapes have been proposed in literature. In this work, two such are applied to arc therapy (IMAT) their results compared that a newly optimized IMAT plan. Methods: simplified cylindrically symmetric model, organ at risk (OAR) is surrounded by planning target volume (PTV). initial plan, steep dose gradient produced variants double...
e21040 Background: SPARC is an albumin-binding protein associated with poor prognosis that may mediate intratumoral accumulation of nab-P. both tumor cells and stromal components. We examined SMS in paired primary (P) metastatic (M) TNBC biopsies (bxs) to 1) determine changes expression, 2) examine potential correlations response therapy nab-P/C/B. Methods: First- second-line TNMBC pts (n = 27) received nabP (100 mg/m2) C (AUC on d1,8,15 a 28 d cycle. B (10 mg/kg) was given d1, 15. Paraffin-...
Currently, there are no data from randomized trials on the use of intraoperative radiotherapy (IORT) as a tumor bed boost in women at high risk local recurrence. The aim this retrospective analysis was to compare toxicity and oncological outcome IORT or simultaneous integrated (SIB) with conventional external beam (WBI) after breast conserving surgery (BCS).Between 2009 2019, patients were treated single dose 20 Gy 50 kV photons, followed by WBI 25 40.05 15 fractions SIB up 58.80-61.60 25-28...
The standard clinical protocol of image-guided IMRT for prostate carcinoma introduces isocenter relocation to restore the conformity multi-leaf collimator (MLC) segments target as seen in cone-beam CT on day treatment. large interfractional deformations volume (CTV) still require introduction safety margins which leads undesirably high rectum toxicity. Here we present further results from 2-Step method generates adaptable plans using Beam Eye View (BEV) and 3D information....
The purpose of this study is to investigate the role centroidal Voronoi tessellation (CVT) and constrained CVT (CCVT) in inverse planning combination with Hybrid Inverse Planning Optimization (HIPO) algorithm HDR brachytherapy prostate cancer. HIPO implemented Oncentra© Prostate treatment system, used for three-dimensional (3D)-ultrasound-based intraoperative high dose rate brachytherapy. utilizes a hybrid iterative process determine most appropriate placement given number catheters fulfil...
Purpose To investigate the suitability of microDiamond detector (mDD) type 60019 (PTW‐Freiburg, Germany) to measure anisotropy function F(r , θ) High Dose Rate (HDR) 192 Ir brachytherapy sources. Methods The HDR source, model mHDR‐v2r (Elekta AB, Sweden), was placed inside a water tank within 4F plastic needle. Four mDDs (mDD1, mDD2, mDD3, and mDD4) were investigated. Each mDD laterally with respect measurements performed at radial distances r = 1 cm, 3 5 polar angles θ from 0° 168°. Monte...
To perform experimental as well independent Monte Carlo (MC) evaluation of the MC algorithm implemented in RADIANCE version 4.0.8, a dedicated treatment planning system (TPS) for 3D electron dose calculations intraoperative radiation therapy (IOERT). The MOBETRON 2000 (IntraOp Medical Corporation, Sunnyvale, CA) IOERT accelerator was employed. PDD and profiles five cylindrical plastic applicators with 50–90 mm diameter 0°, 30° beveling were measured water phantom, at nominal energies 6, 9 12...
Abstract Background Locally advanced recurrent rectal cancer (RRC) requires a multimodal approach. Intraoperative high-dose-rate brachytherapy (HDR-BT) may reduce the risk of local recurrence. However, optimal therapeutic regimen remains unclear. The aim this retrospective monocentric study was to evaluate toxicity HDR-BT after resection RRC. Methods Between 2018 and 2022, 17 patients with RRC received HDR-BT. delivered alone or as an anticipated boost median dose 13 Gy (range 10–13 Gy)...