A5037675160- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Galectins and Cancer Biology
- Gastroesophageal reflux and treatments
- Gastrointestinal disorders and treatments
- Veterinary medicine and infectious diseases
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Nutrition and Health in Aging
- Hepatitis C virus research
- Body Composition Measurement Techniques
- IL-33, ST2, and ILC Pathways
- Clostridium difficile and Clostridium perfringens research
- Digestive system and related health
- Mycobacterium research and diagnosis
- Inflammatory Bowel Disease
- HIV-related health complications and treatments
- Microbial Metabolites in Food Biotechnology
- Platelet Disorders and Treatments
- Cytokine Signaling Pathways and Interactions
- Whipple's Disease and Interleukins
- Probiotics and Fermented Foods
- Celiac Disease Research and Management
- Immunodeficiency and Autoimmune Disorders
- Autoimmune Bullous Skin Diseases
Universidade Federal de Minas Gerais
2014-2024
Feminist Archive South
2024
Faculdade de Ciências Médicas de Minas Gerais
2020
Novant Health
2013
Duke Cancer Institute
2013
Duke University
2011
Tricoci University of Beauty Culture
2005
State of The Art
2004
Financiadora de Estudos e Projetos
2002
Fundação de Amparo à Pesquisa do Estado de Minas Gerais
2002
The use of a new indicator culture medium, Belo Horizonte is proposed for better colony recognition and presumptive identification Campylobacter pylori. This containing brain heart infusion sheep blood agar, was supplemented with 40 mg 2,3,5-triphenyltetrazolium chloride per liter in addition to vancomycin, nalidixic acid, amphotericin B. On pylori present unique golden colonies.
Th17 cells have been associated with immune-mediated diseases in humans but it has still not determined whether they play a role immune thrombocytopenia. We evaluated representative cytokines of the Th17, Th1, Th2 and Treg cell commitment serum patients chronic thrombocytopenia, as well source IL-17A. Higher levels IL-17A Th17-related cytokines, an increased percentage producing CD4+ neutrophils were observed patients. The involved Th1 IFN-γ, IL-2, IL12-p70 percentages also increased, IL-4...
Abstract Background Helicobacter pylori infection is one of the most common infections worldwide and associated with gastric cancer peptic ulcer. Bacterial virulence factors such as CagA have been shown to increase risk both diseases. Studies suggested a causal role for EPIYA polymorphisms in carcinogenesis, it has be geographically diverse. We studied associations between H. patterns duodenal ulcer, an ethnically admixed Western population from Brazil. was determined by PCR confirmed...
Objective Iron deficiency (ID) and iron anaemia (IDA) are global major public health problems, particularly in developing countries. Whilst an association between H. pylori infection ID/IDA has been proposed the literature, currently there is no consensus. We studied effects of on a cohort children undergoing upper gastrointestinal endoscopy for abdominal pain two one developed country. Methods In total 311 (mean age 10.7±3.2 years) from Latin America - Belo Horizonte/Brazil (n = 125),...
Abstract Background Preserved skeletal muscle is essential for the maintenance of healthy bone. Loss bone mineral density (BMD) and strength, considered a predictor BMD, have been demonstrated in patients with cirrhosis, but they are poorly studied chronic hepatitis C (CHC) without cirrhosis. Thus, we aimed to evaluate prevalence low BMD its association body composition, nutritional status CHC. Methods One hundred four subjects [mean age, 50.5 ± 11.3 years; 75.0% males; 67.3% non‐cirrhotic;...
Background: Although enzyme-linked immunosorbent assay (ELISA) is highly sensitive and specific for the diagnosis of Helicobacter pylori infection in adults, their performance children still controversial. Methods: A second-generation ELISA was used to evaluate IgG response H. serum 130 consecutive who underwent upper gastrointestinal endoscopy. The presence determined antral biopsy specimens by culture, urease test, histologic analysis. Results: Sixty-eight (all 20 had duodenal ulcer) were...
ABSTRACT The [ 13 C]urea breath test ( C-UBT) and Helicobacter pylori stool antigen (HpSA) for the diagnosis of H. infection in children were validated. sensitivity, specificity, positive negative predictive values 93.8, 99.1, 97.8, 98.0%, respectively, C-UBT 96.9, 100, HpSA. Both tests are appropriate diagnosing children.
The density of antral gastrin (G)- and somatostatin (D)-immunoreactive cells the contents were investigated in endoscopic biopsy specimens from patients with duodenal ulcer before after eradication Helicobacter pylori. After H. pylori both concentration (p = 0.0002) D-cell 0.01) increased significantly. Conversely, although number G-cells was unchanged, serum 0.001) decreased oxyntic D-cells did not change These results strongly suggest that hypergastrinaemia observed pylori-positive may be...
Abstract Helicobacter pylori is a common component of the human stomach microbiota, possibly dating back to speciation Homo sapiens. A history pathogen evolution in allopatry has led development genetically distinct H. subpopulations, associated with different populations, and more recent admixture among subpopulations can provide information about migrations. However, little known degree which some genes are conserved face admixture, potentially indicating host adaptation, or how virulence...
This PCR-based analysis is the first molecular epidemiological study in Brazil testing Helicobacter pylori cagA and vacA distribution adults with gastric complaints, that includes a large number of carcinoma patients. Multiple-strain infection was identified 11/13.4% s1-m1 cagA+ genotypes were most common patients non-mixed infection. All s1 strains s1b, so subtyping not useful. s1b-m1 associated higher prevalence peptic ulcer than s2-m2 cagA− ones. In conclusion, genotyping may have...
To evaluate a possible association between infection with cag A-positive strains and gastric carcinoma increased risk we studied 119 Helicobacter pylori-positive patients matched controls. The presence of A gene was investigated by PCR in H. pylori isolates biopsy specimens. significant found status distal for both the intestinal diffuse types tumor males females. On other hand, no observed proximal carcinoma.
ABSTRACT The babA2 and cagA genes were investigated in 208 Brazilian Helicobacter pylori strains. A strong association between duodenal ulcer or gastric carcinoma was observed, even after adjusting for confounding factors, such as age, gender, status. -positive strains also independently associated with H . -related diseases.
Th17 cells seem to have an important role in the efficacy of vaccines against Helicobacter pylori. Because children are a target group for human vaccination and Th17/T(reg) intrinsically linked antagonic commitments, we compared gastric levels Th17- T(reg)-associated cytokines adults. IL-6, IL-10 TGF-β1 Foxp3(+) cell numbers were higher, but IL-1β, IL-17A IL-23 lower infected than In conclusion T(reg) instead response H. pylori-infection predominates children.
Helicobacter pylori infection is associated with peptic ulcer and gastric carcinoma. The oral cavity may be a reservoir for H. pylori; however, the results of studies on this subject are controversial. We employed single-step nested polymerase chain reactions (PCR) to detect presence vacA, ureA 16S rDNA genes in stomach, saliva dental plaque 30 subjects. were confirmed by sequencing. Nested amplification was achieved 80% gastric, 30% 20% specimens. Sequencing 10, seven four products from...
The prevalence of Helicobacter pylori infection was evaluated by ELISA in 40 children and teenagers 164 adults from a rural area the State Mato Grosso, Brazil. Antibodies to H. were detected serum 31 (77.5%) 139 (84.7%) adults. increased with age (c2 for trend, p < 0.01) even though no variations occurred region present century terms living conditions or sanitation, economical development migratory influx supporting hypothesis that is also acquired during later life developing countries. An...
Summary We evaluated the role of family in transmission Helicobacter pylori infection preschool‐aged children from a rural district State Minas Gerais, Brazil. Sixty‐six families (66 index children, 63 mothers, 60 fathers and 134 siblings), defined as at least one parent living same household with offspring up to 8 years old, were studied. Odds ratios (OR) 95% confidence intervals (CI) estimated by logistic regression controlling for age, gender, number H. status father, mother siblings. The...
Helicobacter pylori cagA-positive strains and host cytokine proinflammatory polymorphisms have been associated with gastric carcinoma. However, the individual role of each factor has not evaluated yet. Our aim was to evaluate whether IL-1 gene cluster tumor necrosis factor-alpha (TNFA)-307 polymorphisms, as well status, are carcinoma in a non-Caucasian population by analyzing data logistic regression models. We 166 patients noncardia 541 blood donors. Among them, 702 were successfully...
ABSTRACT Comparison of gastric carcinoma and gastritis isolates showed the presence genes, probably associated ( JHP947 JHP940 ), that are situated in a Helicobacter pylori genome region (45 kb J99 68 26695) called “plasticity region.” This presents great variability DNA sequences. We investigated, by PCR, as well third gene which seems to be with HP986 on H. strains isolated from 200 Brazilian patients, 79 whom had carcinomas 53 duodenal ulcers, confirm this association. Gastritis n = 68)...
Summary The ultrastructural features of a helical-shaped bacterium occurring inthe stomach pigs, within the mucus on mucosal surface antral pits,were examined. bacterial cell had three to eight spiral turns, flattened and truncated ends was approximately 4.0 μm long 0.6 wide.In some sections, up six flagella, about 22 nm in diameter, were seen arising from each pole. cytoplasm contained sparse, irregular granules,numerous ribosomes large single-layered membrane-bound granules. In flagella...