A5047208256- Hepatitis B Virus Studies
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- Liver Disease Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- HIV/AIDS drug development and treatment
- Nuclear reactor physics and engineering
- Nuclear Physics and Applications
- Vibrio bacteria research studies
- HIV/AIDS Research and Interventions
- Antibiotic Resistance in Bacteria
- Reproductive System and Pregnancy
- Liver Disease and Transplantation
- HIV, Drug Use, Sexual Risk
- Science and Education Research
- Vaccine Coverage and Hesitancy
- HIV/AIDS oral health manifestations
- Nuclear Materials and Properties
- Bacterial biofilms and quorum sensing
- Veterinary medicine and infectious diseases
- Immune Cell Function and Interaction
- Health Systems, Economic Evaluations, Quality of Life
- Cytomegalovirus and herpesvirus research
- Veterinary Oncology Research
- Energetic Materials and Combustion
Universidade Federal de Mato Grosso
2013-2024
Universidade Federal do Vale do São Francisco
2024
Faculdades Integradas de Cacoal
2020-2021
Los Alamos National Laboratory
2003-2010
Amazon (United States)
2004
Amazon (Germany)
2004
Brazil is a country of continental dimension with population different ethnic backgrounds. Thus, wide variation in the frequencies hepatitis C virus (HCV) genotypes expected to occur. To address this point, 1,688 sequential samples from chronic HCV patients were analyzed. HCV-RNA was amplified by RT-PCR blood collected 1995 2000 at laboratories located cities all Brazilian States. Samples tubes containing gel separator, centrifuged site collection and sent express mail refrigerated container...
Hepatitis B virus (HBV) isolates have been classified in eight genotypes, A to H, which exhibit distinct geographical distributions. Genotypes A, D and F are predominant Brazil, a country formed by miscegenated population, where the proportion of individuals from Caucasian, Amerindian African origins varies region. Genotype F, is most divergent, considered indigenous Americas. systematic molecular characterization HBV different parts world would be invaluable establishing evolutionary...
Hepatitis C is a key challenge to public health in Brazil. The objective of this paper was describe the Brazilian strategy for hepatitis meet 2030 elimination goal proposed by World Health Organization (WHO).A mathematical modeling approach used estimate current HCV-infected population, and evaluate relative costs two different scenarios address HCV disease burden Brazil: (1) if no further changes are made treatment program Brazil; (2) where WHO targets met through diagnosis efforts peaking...
Abstract Background Lamivudine is an oral nucleoside analogue widely used for the treatment of chronic hepatitis B. The main limitation lamivudine use selection resistant mutations that increases with time utilization. Hepatitis B virus (HBV) isolates have been classified into eight genotypes (A to H) distinct geographical distributions. HBV may also influence pathogenic properties and therapeutic features. Here, we analyzed genotype distribution nature frequency among 36 patients submitted...
HLA-G and HLA-E are two nonclassical class I molecules, which have been well recognized as modulators of innate adaptive immune responses, the expression these molecules in virus infected cells has associated with subversion response.In this study we performed a cross-sectional study, systematically comparing benign, pre-malignant malignant laryngeal lesions, correlating demographic clinical variables presence high-risk low-risk HPV types.Laryngeal lesions were collected from 109 patients...
Direct antiviral agents (DAAs) including sofosbuvir (SOF), daclatasvir (DCV), simeprevir (SIM) and ombitasvir, paritaprevir dasabuvir were introduced 2015 in Brazil for treatment of hepatitis C virus (HCV) infection. The aims this study to assess effectiveness safety HCV with DAA real-life world a highly admixed population from Brazil. All Brazilian reference centers invited take part web-based registry, prospectively conducted by the Society Hepatology, outcomes DAAs. Data be collected...
In 2014, Brazil introduced a universal immunization program against the hepatitis A virus (HAV) for children in second year of life, using single dose inactivated vaccine. The objective this study was to evaluate vaccination coverage (VC) HAV Brazil, incidence cases reported five years after implementation program.Secondary data were obtained by searching free access electronic sites Ministry Health, Department Informatics Unified Health System (Departamento de Informática do Sistema Único...
The prevalence of Helicobacter pylori infection was evaluated by ELISA in 40 children and teenagers 164 adults from a rural area the State Mato Grosso, Brazil. Antibodies to H. were detected serum 31 (77.5%) 139 (84.7%) adults. increased with age (c2 for trend, p < 0.01) even though no variations occurred region present century terms living conditions or sanitation, economical development migratory influx supporting hypothesis that is also acquired during later life developing countries. An...
As the mechanisms leading to persistence of hepatitis B virus (HBV) infection are poorly understood and as histocompatibility leucocyte antigen (HLA)-G is well described a tolerogenic molecule, we evaluated HLA-G expression in 74 specimens HBV liver biopsies 10 obtained from previously healthy cadaver donors. were reviewed classified by METAVIR score, was assessed immunohistochemistry. No observed control hepatocytes. In contrast, 57 (77%) showed soluble membrane-bound hepatocytes, biliary...
Abstract Non‐injecting drug users are at high‐risk for acquiring hepatitis B virus (HBV), although the factors contributing to this increased risk not known. In present study, overall and occult HBV infection prevalence rates were determined in a large population of non‐injecting Central‐West region Brazil. genotypes predictors also identified. A total 852 individuals 34 treatment centers interviewed, their serum samples tested presence markers by ELISA. HBsAg anti‐HBc‐positive DNA PCR....
We investigated the seroprevalence of hepatitis A virus (HAV) and E (HEV) infection in subjects living community Manguinhos, Rio de Janeiro, Brazil, assisted at Health Unit Escola Nacional Saúde Pública, Fundação Oswaldo Cruz. After formal consent, individuals were submitted to an interview using a standardized questionnaire. Anti-HAV anti-HEV antibodies detected by ELISA. Statistical analysis was carried out Epi-Info 6.04b software, investigate possible associations between serological...
Hepatitis C virus (HCV) is a significant problem for patients undergoing hemodialysis therapy. This situation has never been studied in Mato Grosso state, central Brazil. study was conducted aiming to estimate the prevalence of anti-HCV and incidence seroconversion main metropolitan region state. 433 from six units were interviewed tested by third-generation enzyme immunoassay. An open cohort who negative at entry created seroconversions assessed monthly. The staff responsible assess whether...
Recent studies have shown that the prevalence of antibody to hepatitis A virus (HAV) is decreasing in several Latin American countries. Brazil a very large and heterogeneous country, showing striking regional differences. With regard sanitary facilities, 81.7% districts south-eastern region sewage systems, compared with only 5.8% northern region. Results sero-epidemiological reported outbreaks indicate change epidemiological pattern country. Individuals, especially those under age 10, are...
Age-related seroprevalence studies that have been conducted in Brazil indicated a transition from high to medium endemicity of hepatitis A virus (HAV) infection the population. However, most these focused on urban populations experience lower incidence rates HAV infection. In current study, prevalence anti-HAV antibodies was investigated children with low socioeconomic status (SES) live periphery three capital cities Brazil. total 1,162 dried blood spot samples were collected individuals...
The dengue virus (DENV), which is frequently involved in large epidemics, and the yellow fever (YFV), responsible for sporadic sylvatic outbreaks, are considered most important flaviviruses circulating Brazil. Because of that, laboratorial diagnosis acute undifferentiated febrile illness during epidemic periods directed towards these viruses, may eventually hinder detection other flaviviruses, including Saint Louis encephalitis (SLEV), widely dispersed across Americas. aim this study was to...
In order to investigate the hepatitis C virus (HCV) genotypes in mid-west region of Brazil, 250 anti-HCV positive blood donors were studied. Among them, serological status was confirmed 205 (82%). HCV RNA detected 165 samples, which genotyped. types 1, 2 and 3 found 67.9%, 3% 29.1% donors, respectively. Goiás state, subtype 1a (50%) most prevalent, followed by subtypes 3a (30.9%) 1b (16.7%). Mato Grosso also predominant (41%), (29.5%) (25%). do Sul equally (36.8%), (21.1%). Subtype 2b rare...
This study was conducted to estimate the prevalence of hepatitis E antibodies (anti-HEV) among individuals exposed swine in rural areas state Mato Grosso (MT) Brazil. The included 310 participants who had an average age 39 years. Fifty-one per cent were female and 26 (8.4%) anti-HEV-positive. Concomitantly, we studied 101 blood donors from urban area capital never lived a or handled swine. Four (4%) these anti-HEV-positive (p = 0.206). When compared been with anti-HEV-negative participants,...
Abstract Background End-stage liver disease is currently a major concern among HIV-positive individuals due to co-infection with hepatotropic virus. Hepatitis C has been pointed out as remarkable factor for that. More recently, hepatitis B virus (HBV) infection also found play role on in this population. HIV-HBV prevalence remains largely unknown vast areas of Brazil. The objective the present study was estimate HBV and HDV HIV-infected subjects living state Mato Grosso, Central region...
In this study, we produced poly(ethylene glycol) (PEG) microspheres of different sizes and adsorbing a medicinal plant mixture, verified their effect in vitro on the viability, superoxide production, bactericidal activity phagocytes blood.The mixture was adsorbed onto PEG its effects were evaluated by flow cytometry fluorescence microscopy.Adsorption herbal achieved particles internalized phagocytes. bearing stimulated release, activated scavenging microbicidal No differences functional...
The prevalence of occult hepatitis B virus (HBV) infection was investigated in 149 surface antigen (HBsAg) negative injecting drug users (IDUs) the Central-West Region Brazil. Of these individuals, 19 were positive for HBV DNA, resulting an 12.7% (19/149); six individuals had anti-HBV core and/or antibodies and 13 markers. All IDUs with reported sexual parenteral risk behaviours. DNA-positive samples successfully genotyped. Genotype D most common (17/19), followed by genotype A (2/19). These...