A5057882182- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Folate and B Vitamins Research
- Hepatitis Viruses Studies and Epidemiology
- Pancreatitis Pathology and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Nutrition and Health in Aging
- Bone health and osteoporosis research
- Digestive system and related health
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Biliary and Gastrointestinal Fistulas
- Intestinal Malrotation and Obstruction Disorders
- Biological Research and Disease Studies
- Abdominal Surgery and Complications
- Coffee research and impacts
- Nonmelanoma Skin Cancer Studies
- Maternal and Neonatal Healthcare
- High Altitude and Hypoxia
- Ultrasound in Clinical Applications
- Potassium and Related Disorders
Hospital de Base
2016-2025
Universidade Federal de Minas Gerais
2024
Universidade Federal da Bahia
2016-2024
Federal Reserve
2024
D’Or Institute for Research and Education
2022
Centro Universitário Central Paulista
2021
Hospital de Base
2021
Hospital Universitário da Universidade de São Paulo
2016
Hospital de Santa Maria
2012
Background & AimsGenetic ancestry or racial differences in health outcomes exist diseases associated with systemic inflammation (eg, COVID-19). This study aimed to investigate the association of genetic and race acute-on-chronic liver failure (ACLF), which is characterized by acute inflammation, multi-organ failure, high risk short-term death.MethodsThis prospective cohort analyzed a comprehensive set data, including among several others, 1274 patients acutely decompensated cirrhosis who...
A hepatite autoimune (HAI) é uma doença hepática crônica que predominantemente afeta mulheres, caracterizada por hipergamaglobulinemia, positividade para autoanticorpos, e alterações histológicas no fígado. Sem tratamento, pode evoluir cirrose insuficiência hepática. síndrome inflamatória de reconstituição imune (SIRI), ocorre após o início da terapia antirretroviral em pacientes com HIV (vírus imunodeficiência humana), desencadear HAI indivíduos predisposição genética doenças autoimunes....
Background and aims Quantifying systemic inflammation (SI) in acutely decompensated cirrhosis (ADC) is of major importance because SI a driver the most severe forms ADC, including acute-on-chronic liver failure (ACLF). Blood biomarkers already evaluated ADC failed to appropriately assess ADC. We aimed investigate whether gene expression related circulating immune cells could quantify Methods Standard (white cell count, C reactive protein, cytokines) genome-wide RNA (RNA-sequencing) were...
Direct antiviral agents (DAAs) including sofosbuvir (SOF), daclatasvir (DCV), simeprevir (SIM) and ombitasvir, paritaprevir dasabuvir were introduced 2015 in Brazil for treatment of hepatitis C virus (HCV) infection. The aims this study to assess effectiveness safety HCV with DAA real-life world a highly admixed population from Brazil. All Brazilian reference centers invited take part web-based registry, prospectively conducted by the Society Hepatology, outcomes DAAs. Data be collected...
The severity of liver disease among hepatitis C patients on hemodialysis is controversial. aim this study was to compare the clinical, biochemical, and histologic characteristics virus (HCV) in those with normal renal function.A case-control carried out 36 HCV 37 function matched for gender, age at infection, estimated time infection.HCV had lower levels alanine aminotransferase viral load. Hepatic fibrosis significantly higher (73%) than (47.2%, P < 0.025); same observed inflammatory...
Aim: Up to 40% of patients with primary biliary cholangitis (PBC) will have a suboptimal biochemical response ursodeoxycholic acid (UDCA), which can be improved by the addition fibrates. This exploratory study aims evaluate long-term real-life different fibrates, including ciprofibrate, in subjects UDCA-unresponsive PBC. Methods: The Brazilian Cholestasis Study Group multicenter database was reviewed assess rates UDCA plus fibrates PBC 1 and 2 years after treatment initiation validated...
The article explores the emergence of cholangiopathy as a post-COVID-19 complication, presenting detailed analysis four cases observed in tertiary hospitals Brazil.The study focuses on patients who developed cholestatic disorders following severe COVID-19, revealing clinical, laboratory, and radiological manifestations.The patients, predominantly male, experienced prolonged hospitalization, mechanical ventilation, hemodynamic support during their initial COVID-19 diagnosis.The exhibited...
Background Ursodeoxycholic acid (UDCA) is the standard treatment for primary biliary cholangitis (PBC), but a significant proportion of patients do not respond adequately, leading to increased risk adverse outcomes. This study aims develop new and straightforward predictive score identify PBC likely achieve complete response UDCA. Methods A logistic regression analysis was conducted using derivation cohort pre-treatment variables associated with led development ALP-A score, calculated as:...
ABSTRACT Background and Aim Primary sclerosing cholangitis (PSC) has been shown to recur after liver transplantation (LT). Some studies have identified certain clinical laboratory variables associated with an increased risk for recurrent PSC (rPSC) in Caucasians. Furthermore, de novo cholangiocarcinoma (CCA) reported anecdotally patients rPSC. This study aims assess the prevalence of rPSC, identify its factors, investigate occurrence CCA a highly admixed population from Brazil. Methods All...
Little is known about primary biliary cholangitis (PBC) in non-whites. The purpose of this study was to evaluate clinical features and outcomes PBC a highly admixed population. Brazilian Cholestasis Study Group multicentre database reviewed assess demographics, treatment patients with PBC. 562 (95% females, mean age 51 ± 11 years) were included. Concurrent autoimmune diseases overlap hepatitis (AIH) occurred, respectively, 18.9% 14%. After follow-up 6.2 5.3 years, 32% had cirrhosis, 7%...
It is known that 10% of all deaths in the United States have gastrointestinal disorders as their underlying cause. As many these patients present with cardiovascular symptoms apparently related to primary disorder, relation between and systems has been under intensive investigation. Observational studies case reports suggested gastroesophageal reflux disease can lead atrial fibrillation this considered implicate multiple mechanisms inflammation, autoimmunity exacerbated autonomic...
Bartter syndrome is a group of rare autosomal-recessive disorders caused by defect in distal tubule transport sodium and chloride. Blood gases plasma electrolytes raise suspicion this diagnosis the definitive made genetic study. Early treatment improves prognosis. The authors present case an 11-month-old child with early failure to thrive severe regurgitation. revealed hypochloraemic metabolic alkalosis, hyponatraemia hypokalaemia. pressure was normal polyuria documented. She began therapy...
Primary sclerosing cholangitis (PSC) is associated with a broad phenotypic spectrum in different populations from diverse ethnic and racial backgrounds. This study aimed to describe the clinical characteristics outcomes of PSC multicenter cohort patients Brazil.Data Brazilian Cholestasis Study Group were retrospectively reviewed assess demographic information PSC, as well outcomes, such transplantation-free survival.This included 210 patients. After excluding 33 (15.7%) overlap syndrome...
Primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH) PBC overlap syndrome (AIH/PBC) have been associated with a higher risk of hepatocellular carcinoma (HCC) extra-hepatic malignancy (EHM). This study aims to assess potential factors cancer development in AIH/PBC.The Brazilian Cholestasis Study Group database was reviewed compare clinical laboratory features patients HCC EHM those without cancer.Among the 752 enrolled, 64 them AIH/PBC, 87 cancers were identified 72 patients,...
Abstract Background: Cholangiopathy has been described in survivors of severe COVID-19, presenting significant clinical parallels to the pre-pandemic condition secondary sclerosing cholangitis critically ill patients (SSC-CIP). Aim: Herein, we examined liver histopathology individuals with persistent cholestasis following COVID-19. Methods: Post-COVID-19 samples were subjected routine staining techniques and cytokeratin 7 immunostaining, portal parenchymal changes semi-quantitatively...
Cholangiopathy has been described in survivors of severe COVID-19, presenting significant clinical parallels to the pre-pandemic condition secondary sclerosing cholangitis critically ill patients (SSC-CIP). We aimed examine liver histopathology individuals with persistent cholestasis after COVID-19.
SUMMARY Hepatopulmonary Syndrome (HPS) is a complication of cirrhosis that worsens the disease's prognosis, pre and post liver transplant. The objective this study to analyze prevalence HPS in cirrhotic patients at our service correlate it with oxygen saturation (SatO2) using pulse oximeter evaluate if useful as screening test for HPS. A prospective was conducted hepatic conventionally selected from 2014 2016. All underwent an echocardiogram microbubbles measurement by oximetry. Those...