Martin Janíčko
A5085389232- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Diseases and Immunity
- Romani and Gypsy Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Parasitic Infections and Diagnostics
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis Viruses Studies and Epidemiology
- Hepatocellular Carcinoma Treatment and Prognosis
- Alcohol Consumption and Health Effects
- Parasitic infections in humans and animals
- Clostridium difficile and Clostridium perfringens research
- Toxoplasma gondii Research Studies
- Gut microbiota and health
- Organ Transplantation Techniques and Outcomes
- Diet, Metabolism, and Disease
- Blood Pressure and Hypertension Studies
- Esophageal and GI Pathology
- Eosinophilic Esophagitis
- Hemoglobinopathies and Related Disorders
- Helicobacter pylori-related gastroenterology studies
- Congenital Anomalies and Fetal Surgery
- Colorectal Cancer Screening and Detection
University of Pavol Jozef Šafárik
2016-2025
Univerzitná Nemocnica Louisa Pasteura
2014-2024
University of Veterinary Medicine in Košice
2016-2022
Center for Disease Analysis
2022
Technical University of Košice
2017
•Patients with acutely decompensated cirrhosis without ACLF develop 3 different clinical courses.•Patients pre-ACLF within 90 days and have high systemic inflammation mortality.•Patients unstable suffer from complications of severe portal hypertension.•Patients stable less frequent lower 1-year mortality risk. Background & AimsAcute decompensation (AD) is defined as the acute development ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or any combination thereof,...
Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure(s). Herein, we aimed to analyze and characterize the precipitants leading both these AD phenotypes. The multicenter, prospective, observational PREDICT study (NCT03056612) included 1,273 non-electively hospitalized patients (No = 1,071; 202). Medical history, clinical data laboratory were collected at enrolment during 90-day...
Background and aims Quantifying systemic inflammation (SI) in acutely decompensated cirrhosis (ADC) is of major importance because SI a driver the most severe forms ADC, including acute-on-chronic liver failure (ACLF). Blood biomarkers already evaluated ADC failed to appropriately assess ADC. We aimed investigate whether gene expression related circulating immune cells could quantify Methods Standard (white cell count, C reactive protein, cytokines) genome-wide RNA (RNA-sequencing) were...
Fecal microbiota transplantation (FMT) seems to be a promising approach in ulcerative colitis (UC) management with the aim of repopulating patient's dysbiotic beneficial bacteria and restore its metabolic activity healthy characteristics. Metabolites present after FMT may improve function integrity intestinal barrier, reduce inflammation, thus induce remission an UC patient. In this study we evaluated whether Simulator Human Intestinal Microbial Ecosystem (SHIME®) model suitable non-invasive...
Background and Aim. Accurate assessment of cirrhotic patient's prognosis is essential for decisions regarding the course treatment. Therefore we aimed to confirm quantify predictive value serum cholesterol triglycerides in liver cirrhosis patients. Material methods. We performed a retrospective observational cohort study on consecutive patients with (n = 191). Relevant clinical laboratory variables were obtained from patients' charts followed two months. Mortality was main outcome. Results....
Hepatocellular carcinoma (HCC) has multiple molecular classes that are associated with distinct etiologies and, besides particular characteristics, also differ in clinical aspects. We aim to characterize the aspects of alcoholic liver disease-related HCC by a retrospective observational study included all consequent patients diagnosed MRI or histologically verified participating centers from 2010 2016. A total 429 were analysis, which 412 (96%) had cirrhosis at time diagnosis. The most...
Prevalence of Hepatitis B is relatively low in developed European countries. However specific subpopulations may exist within each country with markedly different burden. Roma minority very numerous Slovakia and their lifestyle completely to non-Roma population. The aim this study map prevalence compare it population explore potential socio-economic health related risk factors. Cross-sectional epidemiology was performed that included randomly sampled geographically corresponding random...
Background and Aims . Chronic hepatitis C is a systemic disease type 2 diabetes mellitus (T2DM) belongs to more common extrahepatic. The aim of this study was (i) explore the prevalence impaired fasting glucose (IFG) T2DM in patients with chronic C, (ii) effect direct acting antivirals (DAA) treatment on glycemia, (iii) factors that modulate DAA glycemia C. Methods We performed longitudinal retrospective observational focused undergoing Data about history diabetes, virus, treatment, liver...
Background: The Roma population is one of the largest marginalized groups in Europe. aim our work was to summarize morbidity lifestyle-related diseases and infectious living segregated settlements. Methods: We used data from cross-sectional study HepaMeta, which we examined 452 subjects with an average age 34.7 ± 9.1 years, 35.2% were men, 403 non-Roma 33.5 7.4 45.9% men. collected by means a questionnaire, anthropometric measures, analyzed blood urine samples. Results: had higher incidence...
SUMMARY Socioeconomic conditions and health of the Roma population, most numerous minority in Europe, are worse than that non-Roma population. Information about occurrence human toxocarosis other parasitic diseases population is scarce or completely missing. The aim this study was to map seroprevalence living segregated settlements compare data with antibodies Eastern Slovakia. seropositivity Toxocara 429 examined inhabitants reached 22·1%, while only 4/394 samples were found be positive...
Background: The simultaneous presence of chronic hepatitis B (CHB) and metabolic syndrome (MS) in the high-risk Roma community constitutes a high risk for liver cirrhosis potentially hepatocellular carcinoma. This study aims to explore relationship between MS CHB. Methods: Data from cross-sectional HepaMeta Study conducted Slovakia 2011 among living rural communities were used. Participants tested MS, lipid levels - total cholesterol, density lipoproteins (HDL), low (LDL), triglycerides...
Background: The Roma population is one of the major marginalized groups in Europe, having higher incidence all spectrums disease and a shorter life expectancy. Yet, reasons for morbidity its exact prevalence were not properly studied. Objectives: objective our study was to compare frequency metabolic syndrome (MetS) people non-Roma Slovakia, levels uric acid correlation with components syndrome. Methods: A group 452 aged 18–55 years, compared control 403 people. data obtained by...
Background: Obesity-induced metabolic syndrome is a multiple risk factor for cardiovascular (CV) factors and type 2 diabetes, ethnic minorities seem to have unfavourable medical in general more frequently than majority populations. Objective: The aim of this study was evaluate the prevalence relation Roma population compared with non-Roma residing eastern part Slovakia. Results: 123 79 patients were evaluated. Men between 40-55 years age had 4.76-times higher odds women 5.26-times sydrome...
Background: Viral hepatitis B and C prevalence in the Roma population of eastern Slovakia is largely unknown. This study aimed to explore associated risk factors chronic viral among living segregated communities Slovakia. Methods: Data from cross-sectional HepaMeta conducted 2011 rural were used. Participants tested for presence HBsAg, anti-HBc IgG anti-HCV. The assessed mainly via a structured questionnaire/interview. Results: Altogether 452 screened, 11 excluded due missing data. A total...