A5101881241- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Drug-Induced Hepatotoxicity and Protection
- Liver physiology and pathology
- Peptidase Inhibition and Analysis
- Electrolyte and hormonal disorders
- Hemodynamic Monitoring and Therapy
- Hepatitis B Virus Studies
- Infectious Diseases and Tuberculosis
- Fibroblast Growth Factor Research
- Autoimmune and Inflammatory Disorders
- Bone Metabolism and Diseases
- Phytochemicals and Antioxidant Activities
- Clinical Nutrition and Gastroenterology
- Palliative Care and End-of-Life Issues
- Lipid metabolism and disorders
- Childhood Cancer Survivors' Quality of Life
- Hematopoietic Stem Cell Transplantation
- Kruppel-like factors research
- Trace Elements in Health
- Metalloenzymes and iron-sulfur proteins
- Apelin-related biomedical research
- Pediatric Hepatobiliary Diseases and Treatments
- Child Nutrition and Feeding Issues
Marmara University
2000-2022
University of Nottingham
2020
Nottingham University Hospitals NHS Trust
2020
Universitat de Barcelona
2003-2005
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2003-2005
•Patients with acutely decompensated cirrhosis without ACLF develop 3 different clinical courses.•Patients pre-ACLF within 90 days and have high systemic inflammation mortality.•Patients unstable suffer from complications of severe portal hypertension.•Patients stable less frequent lower 1-year mortality risk. Background & AimsAcute decompensation (AD) is defined as the acute development ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or any combination thereof,...
Important progress has been made recently regarding the pathogenesis and treatment of hepatorenal syndrome (HRS). However, scant information exists about factors predicting outcome in patients with cirrhosis HRS. Moreover, prognostic value model end-stage liver disease (MELD) score not validated setting The current study was designed to assess included 105 consecutive Forty-one had type 1 HRS, while 64 2 Patients HRS only more severe renal failure than patients, they also greater impairment...
The fibroblast growth factor 21 (FGF21) hormonal pathway is a metabolic signalling cascade and has been recently identified as the master regulator of glucose, lipids overall energy balance. In this observational, case-control study, we assayed serum levels FGF21 in patients with nonalcoholic fatty liver disease (NAFLD), hepatic manifestation syndrome, examined their association clinical, biochemical histological phenotypes.Serum were by ELISA 82 biopsy-proven NAFLD 77 controls. We analysed...
SummaryInborn errors of selenoprotein expression arise from deleterious variants in genes encoding selenoproteins or biosynthetic factors, some which are associated with neurodegenerative disorders. This study shows that bi-allelic selenocysteine tRNA-specific eukaryotic elongation factor (EEFSEC) cause deficiency, leading to progressive neurodegeneration. EEFSEC an autosomal recessive disorder, manifests global developmental delay, spasticity, ataxia, and seizures. Cerebral MRI primarily...
Objective. Osteoprotegerin (OPG) is a member of the tumor necrosis factor superfamily with pleiotropic effects on inflammation, endocrine function and immune system. Reduced OPG levels are related to insulin resistance. We tested hypothesis that serum may be associated nonalcoholic fatty liver disease (NAFLD). Material methods. Four groups patients were enrolled in present study: subjects definite steatohepatitis (NASH, n = 56), borderline NASH (n 26), simple 17) healthy controls without...
A retrospective study of pretransplantation risk factors predisposing to liver injury following bone marrow transplantation (BMT).Liver complications are a major cause morbidity and mortality BMT. Determination the that likely lead may allow earlier diagnosis after BMT possibly improve prognosis.Medical records patients were reviewed, results serial function tests HBV/HCV serology during pre- posttransplantation 1-year period noted. Presence was defined as alanine aminotransferase levels...
Abstract Background and Aim: To evaluate the possible antifibrotic effects of two drugs, pentoxifylline (PTX) interferon (IFN)‐α as well their combination, on a bile‐duct‐ligated rat hepatic fibrosis model. Methods: Bile ducts 34 female Wistar rats were ligated, 24 bile sham operated. Bile‐duct‐ligated divided into four groups, in which either sterile saline, IFN‐α (100 000 IU/3 days week), PTX (50 mg/kg/day) or + administered. Sham‐operated treated at same doses. On 28th day, decapitated to...
AIM:To assess the role of echo-Doppler ultrasonography in postprandial hyperemia cirrhotic patients by comparing results with hepatic vein catheterization technique. METHODS:Patients cirrhosis, admitted to portal hemodynamic laboratory were included into study.After an overnight fast, (basal and 30 min after a standard meal) studies (basal, 15 performed.Ensure Plus (Abbot Laboratories, North Chicago, IL) was used as liquid meal.Correlation analysis measurements done for basal periods....
Somatostatin receptors have been shown on hepatic stellate cells, and somatostatin infusion has to inhibit cells activation. We aimed test the effects of a long-acting analogue, lanreotide, bile duct ligation-induced liver fibrosis in rats.Thirty-seven Wistar rats were divided into 5 groups as follows: Group 1, ligation+lanreotide; 2, ligation; 3, sham+lanreotide; 4, sham; 5, control group. Lanreotide-autogel (20 mg/kg/month) or saline intraperitoneal doses was administered. Serum...
Objective: Cardiac dysfunction has been reported in both cirrhotic and alcoholic patients. Our aim was to determine the relation of serum N-terminal pro-B-type natriuretic peptide (Nt-proBNP) levels myocardial performance index (MPI) disease severity nonalcoholic Patients Methods: In this prospective study including 25 patients 27 healthy controls, MPI assessed by pulsed-wave tissue Doppler imaging (PW-TDI). The determined Child–Turcotte–Pugh (CTP ) model for end-stage liver (MELD) scores....