Juan Acevedo
A5024015988- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis Viruses Studies and Epidemiology
- Adrenal Hormones and Disorders
- Hormonal Regulation and Hypertension
- Organ Transplantation Techniques and Outcomes
- Inflammatory Bowel Disease
- Colorectal Cancer Screening and Detection
- Thermal Regulation in Medicine
- Pituitary Gland Disorders and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Musculoskeletal pain and rehabilitation
- Antibiotic Resistance in Bacteria
- Clostridium difficile and Clostridium perfringens research
- Esophageal Cancer Research and Treatment
- Cerebral Venous Sinus Thrombosis
- Folate and B Vitamins Research
- Venous Thromboembolism Diagnosis and Management
- Renal function and acid-base balance
- Meningioma and schwannoma management
- Eosinophilic Esophagitis
- Systemic Sclerosis and Related Diseases
University Hospitals Plymouth NHS Trust
2019-2022
European Foundation for the Study of Chronic Liver Failure
2021
Derriford Hospital
2017-2019
Hospital Sant Jaume de Calella
2012-2018
Universitat de Barcelona
2008-2017
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2009-2017
Hospital Clínic de Barcelona
2009-2017
Hospital Universitario San Ignacio
2016-2017
Centro de Investigación Biomédica en Red
2016-2017
Pontificia Universidad Javeriana
2016-2017
Abstract Epidemiology, risk factors, and clinical effect of infections by multiresistant bacteria in cirrhosis are poorly known. This work was a prospective evaluation two series cirrhotic patients admitted with infection or developing during hospitalization. The first studied between 2005 2007 (507 bacterial 223 patients) the second 2010 2011 (162 110 patients). In series, 32% were community acquired (CA), healthcare associated (HCA), 36% nosocomial. Multiresistant (92 infections; 18%)...
Bacterial infection is a frequent trigger of acute-on-chronic liver failure (ACLF), syndrome that could also increase the risk infection. This investigation evaluated prevalence and characteristics bacterial fungal infections causing complicating ACLF, predictors follow-up impact on survival. Patients 407 patients with ACLF 235 acute decompensation (AD). Results 152 (37%) presented at diagnosis; 46%(n=117) remaining 255 developed during (4 weeks). The corresponding figures in AD were 25% 18%...
•Patients with acutely decompensated cirrhosis without ACLF develop 3 different clinical courses.•Patients pre-ACLF within 90 days and have high systemic inflammation mortality.•Patients unstable suffer from complications of severe portal hypertension.•Patients stable less frequent lower 1-year mortality risk. Background & AimsAcute decompensation (AD) is defined as the acute development ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or any combination thereof,...
Background & AimsWe investigated the effect of albumin treatment (20% solution) on hypoalbuminemia, cardiocirculatory dysfunction, portal hypertension, and systemic inflammation in patients with decompensated cirrhosis without bacterial infections.MethodsWe performed a prospective study to assess effects long-term (12 weeks) low doses (1 g/kg body weight every 2 high (1.5 week) serum albumin, plasma renin, function, pressure, levels cytokines, collecting data from 18 infections (the...
Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure(s). Herein, we aimed to analyze and characterize the precipitants leading both these AD phenotypes. The multicenter, prospective, observational PREDICT study (NCT03056612) included 1,273 non-electively hospitalized patients (No = 1,071; 202). Medical history, clinical data laboratory were collected at enrolment during 90-day...
Objective Outside clinical trials, the effectiveness of chromoendoscopy (CE) for long-standing IBD surveillance is controversial. We aimed to assess CE neoplasia detection and characterisation, in real-life. Design From June 2012 2014, patients with were prospectively included a multicentre cohort study. Each colonic segment was evaluated white light followed by 0.4% indigo carmine CE. Specific lesions' features recorded. Optical diagnosis assessed. Dysplasia rate between expert non-expert...
The prevalence of relative adrenal insufficiency (RAI) in critically ill cirrhosis patients with severe sepsis is over 60% and associated features include poor liver function, renal failure, refractory shock, high mortality. RAI may also develop noncritically but its relationship to the clinical course has not yet been assessed. current study was performed 143 admitted for acute decompensation. Within 24 hours after hospitalization plasma renin activity, noradrenaline vasopressin...
The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems and it may have heavily impacted patients with liver cancer (LC). Herein, we evaluated whether the schedule of LC screening or procedures been interrupted delayed because COVID-19 pandemic.An international survey impact on clinical practice trials from March 2020 June 2020, as first phase a multicentre, international, observational project. focus was hepatocellular carcinoma intrahepatic...
Abstract Background & Aims Clinical course and risk factors of death in non‐spontaneous bacterial peritonitis ( SBP ) infections are poorly known. We assessed the prevalence acute kidney injury AKI type‐1 hepatorenal syndrome HRS ), hospital, 30‐day 90‐day mortality 441 decompensated patients. Methods Analysis 615 non‐ (161 urinary UTI 95 cellulitis, 92 suspected infections, bacteraemias, 84 pneumonias, 21 bronchitis, 18 cholangitis, 15 spontaneous empyema, 13 secondary peritonitis, 24...
Recently, important changes have been reported regarding the epidemiology of bacterial infections in liver cirrhosis.There is an emergence multiresistant bacteria many European countries and also worldwide, including United States South Korea.The classic empirical antibiotic treatment (third-generation cephalosporins, e.g. , ceftriaxone, cefotaxime or amoxicillin-clavulanic acid) still effective acquired community, but its failure rate hospital some health-care associated high enough to ban...
Abstract Background & Aims Information about the impact of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in patients with liver cancer is lacking. This study characterizes outcomes and mortality risk this population. Methods Multicentre retrospective, cross‐sectional, international SARS‐CoV‐2 infection registered between February December 2020. Clinical data at diagnosis were registered. Results Two hundred fifty from 38 centres included, 218 hepatocellular carcinoma (HCC)...