Hans Van Vlierberghe
A5051854606- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Liver physiology and pathology
- Renal Transplantation Outcomes and Treatments
- Liver Diseases and Immunity
- Cancer, Hypoxia, and Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Glycosylation and Glycoproteins Research
- Cancer Immunotherapy and Biomarkers
- Endoplasmic Reticulum Stress and Disease
- Hemoglobinopathies and Related Disorders
- Pancreatic and Hepatic Oncology Research
- Alcohol Consumption and Health Effects
- Iron Metabolism and Disorders
- Systemic Lupus Erythematosus Research
- Pancreatitis Pathology and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Transplantation: Methods and Outcomes
- Neonatal Health and Biochemistry
- Organ Donation and Transplantation
Ghent University Hospital
2016-2025
Ghent University
2014-2024
Universitair Ziekenhuis Brussel
2006-2021
ERN GUARD-Heart
2021
European Foundation for the Study of Chronic Liver Failure
2021
VIB-UGent Center for Medical Biotechnology
2017
Creative Research Enterprises (United States)
2016
Bio-Medical Science (South Korea)
2015
GTx (United States)
2014
Fund for Scientific Research
2013
The liver is the largest solid organ in body, yet it remains incompletely characterized. Here we present a spatial proteogenomic atlas of healthy and obese human murine combining single-cell CITE-seq, single-nuclei sequencing, transcriptomics, proteomics. By integrating these multi-omic datasets, provide validated strategies to reliably discriminate localize all hepatic cells, including population lipid-associated macrophages (LAMs) at bile ducts. We then align this across seven species,...
Summary The disease burden of hepatitis C virus ( HCV ) is expected to increase as the infected population ages. A modelling approach was used estimate total number viremic infections, diagnosed, treated and new infections in 2013. In addition, model change progression mortality 2013–2030. Finally, expert panel consensus capture current treatment practices each country. Using today's paradigm, projected decline or remain flat all countries studied. However, same time period, individuals with...
The liver forms a firewall that protects against vascular-borne gut microbes and is commonly impaired in disease.
Metabolic-associated fatty liver disease (MAFLD) represents a spectrum of states ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). Hepatic macrophages, specifically Kupffer cells (KCs), are suggested play important roles in the pathogenesis MAFLD through their activation, although exact played by these remain unclear. Here, we demonstrated that KCs were reduced being replaced macrophages originating bone marrow. Recruited existed two subsets with distinct activation...
•Patients with acutely decompensated cirrhosis without ACLF develop 3 different clinical courses.•Patients pre-ACLF within 90 days and have high systemic inflammation mortality.•Patients unstable suffer from complications of severe portal hypertension.•Patients stable less frequent lower 1-year mortality risk. Background & AimsAcute decompensation (AD) is defined as the acute development ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or any combination thereof,...
Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure(s). Herein, we aimed to analyze and characterize the precipitants leading both these AD phenotypes. The multicenter, prospective, observational PREDICT study (NCT03056612) included 1,273 non-electively hospitalized patients (No = 1,071; 202). Medical history, clinical data laboratory were collected at enrolment during 90-day...
Knowledge on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in liver transplant recipients is lacking, particularly terms of severity the disease. The aim this study was to describe demographic, baseline clinical characteristics and early outcomes a European cohort with SARS-CoV-2 infection.We conducted an international prospective across Europe confirmed by microbiological assay during first outbreak COVID-19 pandemic. Baseline characteristics, presentation,...
Background Transarterial chemoembolization (TACE) is the recommended treatment for intermediate hepatocellular carcinoma (HCC) according to Barcelona Clinic Liver Cancer guidelines. Prospective uncontrolled studies suggest that yttrium 90 (90Y) transarterial radioembolization (TARE) a safe and effective alternative. Purpose To compare efficacy safety of TARE with TACE unresectable HCC. Materials Methods In this single-center prospective randomized controlled trial (TRACE), 90Y glass was...
Graft hyperperfusion in small-for-size grafts (SFSG) is considered the main causal factor of syndrome (SFSS). We compared SFSG with a graft-to-recipient body ratio < or =0.8, and without graft inflow modulation (GIM) by means hemi-portocaval shunt (HPCS). Thirteen patients underwent adult-to-adult living donor liver transplantation (AALDLT): G1, n = 5 [4 right livers (RL) 1 left (LL)] GIM, G2, 8 (4 RL 4 LL) GIM. In G2 patients, portal vein flow (PVF) was significantly reduced HPCS: 190 +/-...
To evaluate the clinical significance of modulating recipient portal inflow (rPVF) through perioperative ligation splenic artery in adult living-donor liver transplantation (ALDLTx) by focusing on vascular complications, intractable ascites production, and prevention small-for-size syndrome (SFSS).In ALDLTx, graft flow is enhanced to at least twice donor value, raising total inflow. Recipient hepatic arterial (rHAF) lower than expected. Portal hyperperfusion small grafts larger recipients...
CT and MR Imaging Findings in Focal Nodular Hyperplasia of the LiverRadiologic—Pathologic CorrelationK. J. Mortelé1, M. Praet2, H. Van Vlierberghe3, Kunnen1 P. R. Ros4Audio Available | Share