A5001720527- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Function and Risk Factors
- Liver Disease Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Immune cells in cancer
- Head and Neck Cancer Studies
- Peripheral Artery Disease Management
- Renal and Vascular Pathologies
- Medical Imaging and Pathology Studies
- Meningioma and schwannoma management
- Ocular Oncology and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Asthma and respiratory diseases
- Lymphoma Diagnosis and Treatment
- Malaria Research and Control
- Single-cell and spatial transcriptomics
- Dental Radiography and Imaging
VIB-UGent Center for Inflammation Research
2021-2025
Ghent University
2021-2024
Medical University of Vienna
2014-2019
RWTH Aachen University
2011-2014
Christian Doppler Laboratory for Thermoelectricity
2014
Universitätsklinikum Aachen
2010-2013
Freie Universität Berlin
1988-2008
Humboldt-Universität zu Berlin
1999
Hegau-Bodensee-Klinikum Singen
1996-1997
Klinik und Poliklinik für Strahlentherapie und Radioonkologie
1988-1993
The liver is the largest solid organ in body, yet it remains incompletely characterized. Here we present a spatial proteogenomic atlas of healthy and obese human murine combining single-cell CITE-seq, single-nuclei sequencing, transcriptomics, proteomics. By integrating these multi-omic datasets, provide validated strategies to reliably discriminate localize all hepatic cells, including population lipid-associated macrophages (LAMs) at bile ducts. We then align this across seven species,...
Our understanding of the functional heterogeneity resident versus recruited macrophages in diseased liver is limited. A population lipid-associated (LAMs) has been reported to populate alongside Kupffer cells (KCs). However, precise roles these distinct macrophage subsets remain elusive. Here, using proteogenomics, we have identified LAMs multiple models injury. Moreover, found that this phenotype not specific macrophages, as a subset KCs can also adopt LAM-like mouse and human liver. By...
Separate analysis of endocardial and epicardial myocardial layer deformation has become possible using strain-encoded cardiovascular magnetic resonance (SENC) 2D-dimensional speckle tracking echocardiography (Echo). This study evaluated compared both modalities for the assessment infarct transmurality as defined by late gadolinium enhancement (LGE) (CMR). In 29 patients (age 62.4 ± 11.7 years, 23 male) with ischaemic cardiomyopathy, SENC 1.5 T CMR Echo were performed. Peak circumferential...
Background: Mucosal mast cells (MC) are key players in IgE-mediated food allergy (FA). The evidence on the interaction between gut microbiota, MC and susceptibility to FA is contradictory. Objective: We tested hypothesis that commensal bacteria essential for migration their maturation impacting FA. Methods: development severity of symptoms was studied sensitized germ-free (GF), conventional (CV), mice mono-colonized with L. plantarum WCFS1 or co-housed CV mice. were phenotypically...
Allergic poly-sensitization affects a large number of allergic patients and poses great challenge for their treatment. In this study we evaluated the effects probiotic Escherichia coli Nissle 1917 (EcN) expressing birch grass pollen allergen chimera 'Bet v 1, Phl p 1 5' (EcN-Chim) on allergy prevention after oral or intranasal application in poly-sensitized mice. contrast to application, pretreatment with EcN-Chim prior led significant reduction lung inflammation (eosinophils, IL-5, IL-13...
Upon infecting its vertebrate host, the malaria parasite initially invades liver where it undergoes massive replication, whilst remaining clinically silent. The coordination of host responses across complex tissue during infection remains unexplored. Here, we perform spatial transcriptomics in combination with single-nuclei RNA sequencing over multiple time points to delineate host-pathogen interactions Plasmodium berghei-infected tissues. Our data reveals significant changes gene expression...
The aim of this study was to evaluate whether intravenous injection an ultrasound contrast agent aids in the visualization focal liver lesions on power Doppler images.Fifty patients with were studied by B-mode and sonography before after Levovist (galactose-based microbubbles; 10 ml a concentration 300 mg/ml). Thirty-two had malignant (19 metastases, 12 hepatocellular carcinomas, 1 cholangiocellular carcinoma), while 18 benign (12 hemangiomas, 2 nodular hyperplasias, 4 others).After medium...
Background Recently, a protein homologous to glutathione-S-transferases (GST) was detected in prominent amounts birch pollen by proteomic profiling. As members of the GST family are relevant allergens mites, cockroach and fungi we investigated allergenic relevance from (bGST). Methodology bGST expressed Escherichia coli, purified characterized mass spectrometry. Sera 217 pollen-allergic patients were tested for IgE-reactivity ELISA. The mediator-releasing activity analysed with IgE-loaded...
Tachycardia-induced cardiomyopathy refers to an impairment in left-ventricular function due chronic or prolonged tachycardia. We describe a heart transplant patient who developed cardiogenic shock tachycardia-induced cardiomyopathy. Low-output failure was further aggravated by administration of short-acting β-blocker during invasive hemodynamic monitoring. In contrast, rate control increasing doses ivabradine supported recovery from and led improvement the patient’s clinical condition as...
Abstract Epidemiological and experimental studies have shown an inverse relationship between infections with certain parasites a reduced incidence of allergic diseases. We others that infection Toxoplasma gondii prevents the development allergy in mice. To establish whether this beneficial effect could be recapitulated by soluble products parasite, we tested extract derived from T . tachyzoites. Immunization BALB/c mice tachyzoites lysate antigen (TLA) elicited mixed Th1/Th2 responses. When...
MR and CT examinations of 16 patients with lymphoma, pseudolymphoma inflammatory pseudotumours were analysed to describe morphologic features lymphocytic infiltration. Density signal did not allow for differentiation, but localisation was the most important criterion: lymphoma located in anterior superior orbit, being retrobulbar lesions. Differentiation is clinical importance, since both are accompanied by generalised malignant while localised. Imaging topographic relations lens, optic...
Abstract The liver is the largest solid organ in body, yet it remains incompletely characterized. Here, we present a spatial proteogenomic atlas of healthy human and murine combining single-cell CITE-seq, single-nuclei sequencing, transcriptomics proteomics. By integrating these multi-omic datasets, provide validated strategies to reliably discriminate localize all hepatic cells. We then align this across seven species, revealing conserved program bona fide Kupffer cells bile-duct...
The absorption of the elements iodine, gadolinium and ytterbium in various dilutions was studied relation to CT. Regression analysis specific CT density measurements showed that decreases from iodine. These results were confirmed by experiments using ten dogs. Boli 0.5 molar used for angio-CT without table movement largest increase aorta liver with an average 190HU 21HU respectively compared iodine which gave 157HU 12HU respectively. animal experimental studies suggest are suitable contrast...