A5048367683- Monoclonal and Polyclonal Antibodies Research
- Allergic Rhinitis and Sensitization
- Immunotherapy and Immune Responses
- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- SARS-CoV-2 and COVID-19 Research
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Vaccine Coverage and Hesitancy
- Glycosylation and Glycoproteins Research
- Mosquito-borne diseases and control
- Bacterial Infections and Vaccines
- Hepatitis Viruses Studies and Epidemiology
- Dermatology and Skin Diseases
- Malaria Research and Control
- Viral gastroenteritis research and epidemiology
- Herpesvirus Infections and Treatments
- Pneumonia and Respiratory Infections
- Vector-borne infectious diseases
- Immune Cell Function and Interaction
- Travel-related health issues
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Pediatric health and respiratory diseases
- Transgenic Plants and Applications
Medical University of Vienna
2016-2025
University of Vienna
1996-2021
Austrian Agency for Health and Food Safety
2021
Paracelsus Medical University
2021
Medical University of Graz
2021
Children's Health Ireland at Crumlin
2021
Universitätsklinik für Kinder und Jugendpsychiatrie
2021
St Anna Children's Hospital
2021
Universitätszahnklinik Wien
2021
University of Gothenburg
1993-2015
Abstract Inhibitors of PD-1 signaling have revolutionized cancer therapy. and PD-L1 antibodies been approved for the treatment cancer. To date, therapeutic inhibitors not compared in a functional assay. We used an efficient T cell reporter platform to evaluate efficacy five clinically block signaling. The half maximal effective concentrations (EC 50 ) nivolumab pembrolizumab were 76.17 ng/ml (95% CI 64.95–89.34 ng/ml) 39.90 (34.01–46.80 ng/ml), respectively. EC values 6.46 (5.48–7.61 6.15...
Summary Background and Objective The mechanisms operative in specific immunotherapy (SIT) of Type I allergy are not completely understood. In the present study we evaluated immunological changes during SIT pollinosis. Method Eight patients suffering from pollinosis (monosensitized to grass pollen) were treated with conventional SIT. All subjects had IgE for Phi p 1. a major allergen timothy grass. vitro reactivity pollen extract recombinant 1 evaluated. Subjects examined at three occasions:...
Abstract Immunosenescence is characterised by reduced B and T cell responses. Evidence shows that booster vaccinations are less effective in elderly people, but data on the efficacy of primary immunisation sparse. We conducted a monocentric, open label, phase IV trial to compare immune responses using inactivated, adjuvanted Japanese Encephalitis vaccine 30 people (mean 69, range 61–78 years) younger 24, 18–30 years). Humoral cellular were analysed relation age cytomegalovirus (CMV)...
The IgE-mediated and Th2-dependent late-phase reaction remains a mechanistically enigmatic daunting element of human allergic inflammation. In this study, we uncover the FcεRI on dendritic cells (DCs) as key in vivo component form allergy. Because rodent, unlike human, DCs lack FcεRI, mechanism could be revealed only by using new transgenic mouse model with human-like expression DCs. presence IgE allergen, FcεRI(+) instructed naive T to differentiate into Th2 vitro boosted allergen-specific...
Low responsiveness/nonresponsiveness is characterized by an insufficient immune response upon primary and/or booster vaccination and affects 1-10% of vaccinees. In the current study, we aimed to investigate whether nonresponsiveness Ag/vaccine-specific phenomenon clarify underlying immunological mechanisms. Nonresponders tick-borne encephalitis (TBE) or hepatitis B Ag with a history previous TBE vaccinations were vaccinated influenza vaccine compared high responders in terms humoral cellular...
Abstract Reported incidence of pertussis in the European Union (EU) and Economic Area (EEA) varies may not reflect real situation, while vaccine-induced protection against diphtheria tetanus seems sufficient. We aimed to determine seroprevalence DTP antibodies EU/EEA countries within age groups 40–49 50–59 years. Eighteen collected around 500 samples between 2015 2018 (N = 10,302) which were analysed for IgG-DTP specific antibodies. The proportion sera with toxin antibody levels ≥100 IU/mL,...
Background Individuals with secondary immunodeficiencies belong to the most vulnerable groups succumb COVID-19 and thus are prioritized for SARS-CoV-2 vaccination. However, knowledge about persistence anamnestic responses following SARS-CoV-2-mRNA vaccinations is limited in these patients. Methods In a prospective, open-label, phase four trial we analyzed S1-specific IgG, neutralizing antibodies cytokine previously non-infected patients cancer or autoimmune disease during primary mRNA...
Several COVID-19 vaccines have been approved. The mRNA vaccine from Pfizer/BioNTech (Comirnaty, BNT162b2; BNT) and the vector AstraZeneca (Vaxzevria, ChAdOx1; AZ) widely used. induce high antibody T cell responses, also to SARS-CoV-2 variants, but are costlier less stable than slightly effective vaccines. For vaccines, heterologous vaccination schedules generally proven more homologous schedules.
A multicenter, randomized, open-label, phase II study (HERIZON; NCT02795988) was conducted to evaluate the clinical and immunologic efficacy of HER-Vaxx (IMU-131), a B-cell, peptide-based vaccine targeting HER2 overexpressed in 6% 30% gastroesophageal adenocarcinomas (GEA).
Background: Probiotic lactic acid bacteria (LAB) are able to modulate the host immune system and clinical trials have demonstrated that specific strains capacity reduce allergic symptoms. Therefore, we aimed evaluate potential of recombinant LAB producing major birch pollen allergen Bet v 1 for mucosal vaccination against allergy. Methods: Recombinant 1‐producing Lactobacillus plantarum Lactococcus lactis were constructed. Their immunogenicity was compared with purified by subcutaneous...
The authors studied the influence of vitamin A deficiency on immediate and delayed type hypersensitivity as well granulocyte-mediated inflammatory reactions in depleted control rats. number circulating leucocytes was 43% higher deficient than animals. leucocytosis a result general increase white blood cells not due to an one particular type. ratio between CD4+ CD8+ T unchanged. rats had four times T-cell proliferative response two interferon-gamma production vitro In accordance, DTH reaction...
Summary Background Almost 100 million allergic patients are sensitized to the major birch pollen allergen, Bet v 1, a 17 kDa protein containing most of IgE epitopes present in pollens trees belonging Fagales order and plant‐derived food. Objective Our aim was develop an approach for rational design B cell epitope‐derived, non‐allergenic peptide allergy vaccines. Methods According three‐dimensional (3‐D) structure six peptides comprising 25–32 preferably solvent‐exposed amino acids were...
Background: Mucosal mast cells (MC) are key players in IgE-mediated food allergy (FA). The evidence on the interaction between gut microbiota, MC and susceptibility to FA is contradictory. Objective: We tested hypothesis that commensal bacteria essential for migration their maturation impacting FA. Methods: development severity of symptoms was studied sensitized germ-free (GF), conventional (CV), mice mono-colonized with L. plantarum WCFS1 or co-housed CV mice. were phenotypically...
Immunsuppression unterschiedlicher Genese ist mit einem erhöhten Infektionsrisiko verbunden; daher die Prävention von impfpräventablen Erkrankungen bei den betroffenen Personengruppen besonders wichtig. Allerdings das Angehen Impfungen oftmals reduziert bzw. Applikation Lebendimpfungen während kontraindiziert. Im folgenden Expertenstatement wurden Empfehlungen zur Impfversorgung auf der Basis bestehender Evidenz und theoretischen/immunologischen Überlegungen erarbeitet. Ein erster,...
(1) Background: The Austrian supply of COVID-19 vaccine is limited for now. We aim to provide evidence-based guidance the authorities in order minimize COVID-19-related hospitalizations and deaths Austria. (2) Methods: used a dynamic agent-based population model compare different vaccination strategies targeted elderly (65 ≥ years), middle aged (45–64 younger (15–44 vulnerable (risk severe disease due comorbidities), healthcare workers (HCW). First, outcomes were optimized an initially...
Abstract Purpose: HER2/neu is overexpressed in up to 30% of gastroesophageal adenocarcinomas (GEA) and linked poor prognosis. Recombinant mAbs treat HER2/neu-overexpressing cancers are effective with limitations, including resistance toxicity. Therefore, we developed a therapeutic B-cell epitope vaccine (IMU-131/HER-Vaxx) consisting three fused epitopes from the extracellular domain coupled CRM197 adjuvanted Montanide. This phase Ib study aimed evaluate optimal/safe dose leading...