A5001961559- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Cerebrovascular and Carotid Artery Diseases
- SARS-CoV-2 detection and testing
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Vaccine Coverage and Hesitancy
- COVID-19 epidemiological studies
- Estrogen and related hormone effects
- Menopause: Health Impacts and Treatments
- Genetic Associations and Epidemiology
- Pregnancy and preeclampsia studies
- Acute Ischemic Stroke Management
- Acute Myocardial Infarction Research
- Nutritional Studies and Diet
- Breastfeeding Practices and Influences
- Cardiovascular Issues in Pregnancy
- Immune responses and vaccinations
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Digital Imaging for Blood Diseases
- Cardiovascular Health and Risk Factors
- Periodontal Regeneration and Treatments
- Animal Virus Infections Studies
Innsbruck Medical University
2019-2025
Universität Innsbruck
2019-2025
Institute of Health Economics
2023
University Hospital of Bern
2019
University of Cambridge
2019
Patients with ischaemic stroke or transient attack (TIA) are at high risk of recurrent and other cardiovascular diseases commonly suffer from reduced quality life. We aimed to determine whether the disease management programme STROKE-CARD can prevent improve life in these patients.In this pragmatic open-label two-centre randomised controlled trial blinded outcome assessment, we randomly assigned patients acute TIA (ABCD2 score ≥3) a 2:1 ratio receive care standard care. is by...
Measures implemented to reduce the spread of SARS-CoV-2 have resulted in a decrease physical activity (PA) while sedentary behaviour increased. The aim present study was explore associations between PA and mental health Austria during COVID-19 social restrictions. In this web-based cross-sectional (April–May 2020) moderate-to-vigorous (MVPA), sitting time, time spent outdoors were self-reported before self-isolation. Mental well-being assessed with Warwick-Edinburgh Well-being Scale, Beck...
Several COVID-19 vaccines have been approved. The mRNA vaccine from Pfizer/BioNTech (Comirnaty, BNT162b2; BNT) and the vector AstraZeneca (Vaxzevria, ChAdOx1; AZ) widely used. induce high antibody T cell responses, also to SARS-CoV-2 variants, but are costlier less stable than slightly effective vaccines. For vaccines, heterologous vaccination schedules generally proven more homologous schedules.
BackgroundCorrelates of protection could help to assess the extent which a person is protected from SARS-CoV-2 infection after vaccination (so-called breakthrough infection). We aimed clarify associations antibody and T-cell responses against COVID-19 with risk whether measurement these enhances prediction.MethodsWe did an open-label, phase 4 trial in two community centres Schwaz district Federal State Tyrol, Austria, before emergence omicron (B.1.1.529) variant SARS-CoV-2. included...
Background: To provide updated estimates on SARS-CoV-2 antibody seroprevalence and average titres for Central Europe. Methods: In repeat cross-sectional investigations (1 May 2022 to 9 March 2023) involving 28,768 blood donors in the Federal State of Tyrol, Austria (participation rate: 87.0%), we measured Spike receptor-binding domain (RBD) Nucleocapsid IgG antibodies (37,065 12,645 samples), estimated monthly seroprevalences geometric mean titres. Results: Median age participants was 45.4...
There is uncertainty about the seroprevalence of anti-SARS-CoV-2 antibodies in general population Austria and waning over time. We conducted a seroepidemiological study between June 2020 September 2021, enrolling blood donors aged 18–70 years across Tyrol, (participation rate: 84.0%). analyzed serum samples for against spike or nucleocapsid proteins SARS-CoV-2. performed total 47,363 taken from 35,193 individuals (median age, 43.1 (IQR: 29.3–53.7); 45.3% women; 10.0% with prior SARS-CoV-2...
Anita Siller , Ph.D., Lisa Seekircher Daniela Schmidt Lena Tschiderer Peter Willeit Harald Schennach M.D., and Marco Amato M.D.. Ann Lab Med -0001;0:. https://doi.org/10.3343/alm.2024.0448
Abstract Aims Observational studies have shown a U-shaped association between age at menarche (AAM) and cardiovascular disease (CVD). We assessed non-linearity of the observational potential causal relationship AAM CVD using data from European Prospective Investigation into Cancer Nutrition—Cardiovascular Disease (EPIC-CVD) study UK Biobank. Methods results included women without pre-existing myocardial infarction (MI) or stroke baseline. estimated hazard ratios for incident MI, ischaemic...
Pooled platelet (PLT) production methods differ worldwide. In Europe, the buffy coat (BC) method is predominantly used, with four to eight BCs being pooled produce single- or double-dose PLT products. The European Directorate for Quality of Medicines & HealthCare (EDQM) blood guide and Austrian legislation define a therapeutic unit as ≥ 2 × 1011 PLTs/unit. We optimized manufacturing steps doubledose products from six BCs, aiming enhance efficiency while maintaining product quality. stepwise...
To analyze the frequency of inadequately treated risk factors in a large representative cohort patients with acute ischemic stroke or TIA and to estimate proportion events potentially avertable by guideline-compliant preventive therapy compared status quo.A total 1,730 from Poststroke Disease Management STROKE-CARD trial (NCT02156778) were recruited between 2014 2017. We focused on 8 conditions amenable drug 3 lifestyle behaviors assessed pre-event factor control retrospect.The at least 1...
Because a large proportion of the Austrian population has been infected with SARS-CoV-2 during high incidence periods in winter 2021/2022, up-to-date estimates seroprevalence anti-SARS-CoV-2 antibodies are required to inform upcoming public health policies. We quantified anti-Spike IgG antibody levels 22,607 individuals that donated blood between October 2021 and April 2022 across Tyrol, Austria (participation rate: 96.0%). Median age participants was 45.3 years (IQR: 30.9−55.1); 41.9% were...
Background Observational studies have shown that women with an early menopause are at higher risk of stroke compared a later menopause. However, associations subtypes inconsistent, and the causality is unclear. Methods Results We analyzed data UK Biobank EPIC-CVD (European Prospective Investigation Into Cancer Nutrition-Cardiovascular Diseases) study. A total 204 244 postmenopausal without history baseline were included (7883 from [5292 subcohort], 196 361 Biobank). Pooled mean age was 58.9...
Current guidelines recommend measuring carotid intima-media thickness (IMT) at the far wall of common artery (CCA). We aimed to precisely quantify associations near vs. CCA-IMT with risk for atherosclerotic cardiovascular disease (CVD, defined as coronary heart or stroke) and their added predictive values.We analysed individual records 41 941 participants from 16 prospective studies in Proof-ATHERO consortium {mean age 61 years [standard deviation (SD) = 11]; 53% female; 16% prior CVD}. Mean...
Hemoglobin levels are commonly assessed to prevent causing or worsening of anemia in prospective blood donors. We compared head-to-head the accuracy different technologies for measuring hemoglobin suitable use mobile donation units. included 144 persons donating platelets at Central Institute Blood Transfusion and Immunology Innsbruck, Austria. were measured venous using portable hemoglobinometer HemoCue Hb-801 non-invasively OrSense NBM-200, values obtained with Sysmex XN-430, an automated...
Abstract Background Current guidelines recommend measuring carotid intima-media thickness (IMT) at the common artery (CCA), because these measurements are considered to have a higher precision and reproducibility than IMT values assessed bifurcation (BIF) or internal (ICA). However, available evidence from prospective cohort studies on association with disease risk is conflicting. Purpose We aimed reliably quantify associations of CCA-, BIF- ICA-IMT for atherosclerotic cardiovascular their...
Anti-Spike IgG antibodies against SARS-CoV-2, which are elicited by vaccination and infection, correlates of protection infection with pre-Omicron variants. Whether this association can be generalized to infections Omicron variants is unclear. We conducted a retrospective cohort study 8457 blood donors in Tyrol, Austria, analyzing 15,340 anti-Spike antibody measurements from March 2021 December 2022 assessed Abbott SARS-CoV-2 II chemiluminescent microparticle immunoassay. Using Bayesian...
In response to a large outbreak of the SARS-CoV-2 Beta (B.1.351) variant in district Schwaz, Austria, rapid mass vaccination campaign with BNT162b2 was carried out spring 2021, immunizing more than 70% adult population within one week. Subsequent analysis revealed that associated significant reduction new infections compared control districts. Here, we aimed evaluate both SARS-CoV-2-specific T- and B-cell responses at 35 ± 8 215 7 days after second dose 600 study subjects who participated...
Abstract Background Pregnancy associated hypertensive disorders including pre-eclampsia/eclampsia and gestational hypertension have been related to unfavourable maternal cardiovascular risk factor profiles a significantly higher develop disease (CVD) events in observational studies. However, whether these associations are causal is not yet fully understood. Purpose We conducted Mendelian Randomisation study investigate genetic liability factors the of experiencing CVD outcomes. Methods...
Objective Observational studies show that hypertensive disorders of pregnancy (HDPs) are related to unfavourable maternal cardiovascular disease (CVD) risk profiles later in life. We investigated whether genetic liability pre-eclampsia/eclampsia and gestational hypertension is associated with CVD factors occurrence events. Methods obtained associations HDPs from a genome-wide association study used individual participant data the UK Biobank obtain events (defined as myocardial infarction or...
Abstract Background Observational studies have shown that women with an early menopause are at higher risk of stroke compared to a later menopause. However, associations subtypes inconsistent and the causality is unclear. Purpose We conducted large-scale analysis investigate observational association between age different types accompanied by Mendelian Randomisation evaluate causality. Methods analysed data UK Biobank EPIC-CVD study. Postmenopausal without history baseline were eligible for...