A5022961134- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- Viral-associated cancers and disorders
- Immune cells in cancer
- Immunodeficiency and Autoimmune Disorders
- Renal Transplantation Outcomes and Treatments
- Biosimilars and Bioanalytical Methods
- Immune Response and Inflammation
- Therapeutic Uses of Natural Elements
- Spondyloarthritis Studies and Treatments
- Acute Lymphoblastic Leukemia research
- Cancer Immunotherapy and Biomarkers
- Phagocytosis and Immune Regulation
- Voice and Speech Disorders
- Dysphagia Assessment and Management
- Health Systems, Economic Evaluations, Quality of Life
- Inflammatory Bowel Disease
- vaccines and immunoinformatics approaches
- Respiratory and Cough-Related Research
- Cytokine Signaling Pathways and Interactions
- Antimicrobial Peptides and Activities
- Lymphoma Diagnosis and Treatment
VIB-UGent Center for Inflammation Research
2025
University of Birmingham
2017-2020
Institute of Immunology
2019-2020
Cancer Research UK
2020
Ipsos (United Kingdom)
2018
Cardiff University
2015-2017
GlaxoSmithKline (Belgium)
2014
Manchester Royal Infirmary
2012
Royal London Hospital
1998
Our understanding of the functional heterogeneity resident versus recruited macrophages in diseased liver is limited. A population lipid-associated (LAMs) has been reported to populate alongside Kupffer cells (KCs). However, precise roles these distinct macrophage subsets remain elusive. Here, using proteogenomics, we have identified LAMs multiple models injury. Moreover, found that this phenotype not specific macrophages, as a subset KCs can also adopt LAM-like mouse and human liver. By...
BackgroundTargeting of MDSCs is a major clinical challenge in the era immunotherapy. Antibodies which deplete murine models can reactivate T cell responses. In humans such approaches have not developed due to difficulties identifying targets amenable translation.MethodsRNA-sequencing M-MDSCs and G-MDSCs from cancer patients was undertaken. Flow cytometry immunohistochemistry blood tumours determined MDSC CD33 expression. were treated with Gemtuzumab ozogamicin internalisation kinetics, death...
The chemokine receptor, CXC receptor 4 (CXCR4), is selective for ligand 12 (CXCL12), broadly expressed in blood and tissue cells, essential during embryogenesis hematopoiesis. CXCL14 a homeostatic with unknown selectivity preferential expression peripheral tissues. Here, we demonstrate that synergized CXCL12 the induction of responses primary human lymphoid cells cell lines express CXCR4. Combining subactive concentrations 100–300 nM resulted chemotaxis exceeded maximal were obtained alone....
CXCL14 is a chemokine with an atypical, yet highly conserved, primary structure characterized by short N terminus and high sequence identity between human mouse. Although it induces chemotaxis of monocytic cells at concentrations, its physiological role in leukocyte trafficking remains elusive. In contrast, several studies have demonstrated that broad-spectrum antimicrobial peptide expressed abundantly constitutively epithelial tissues. this study, we further explored the properties against...
Reflecting their importance in immunity, the activity of chemokines is regulated on several levels, including tissue and context-specific expression availability cognate receptor target cells. Chemokine synergism, affecting both chemokine function, has emerged as an additional control mechanism. We previously demonstrated that CXCL14 a positive allosteric modulator CXCR4 its ability to synergise with CXCL12 diverse cellular responses. Here, we have extended our study homeostatic, well...
Abstract The localization of memory T cells to human skin is essential for long-term immune surveillance and the maintenance barrier integrity. expression CCR8 during naive cell activation controlled by skin-specific factors derived from epidermal keratinocytes not resident dendritic cells. In this study, we show that CCR8-inducing are heat stable protease resistant include vitamin D3 metabolite 1α,25-dihydroxyvitamin PGE2. effect either alone on was weak, whereas their combination resulted...
Acute graft versus host disease (aGvHD) is a major cause of early morbidity post-haematopoietic stem cell transplantation with minor histocompatibility antigens being contributing factor. One mHA encoded by the UDP glycosyltransferase 2 family polypeptide B17 (UGT2B17) gene has been shown to be immunogenic because differential expression in donor and recipient. We investigated effects homozygous deletion UGT2B17 on severity acute aGvHD post-HSCT HLA-matched related donors. 115 recipient HLA...
Meeting abstracts Precision medicine with modern immunotherapeutics often requires pre-therapeutic access to novel and sometimes complex diagnostic tests. Test development tests including reimbursement lacks behind availability of medicines, potentially
Disease remission is a key target while managing patients with ulcerative colitis (UC). A multi-center medical chart-review study of UC was conducted among physicians (majority: gastroenterologists) in hospitals/private practices to collect de-identified data on who are currently biologic/biosimilar or recently discontinued one within past three months. Physicians from the five EU countries (5EU) were screened for practice-duration and patient-volume recruited large panel be geographically...
Background: Epstein–Barr virus (EBV) is a ubiquitous lymphotropic which preferentially infects B‐cells 1,2 , but can also infect T‐cells and NK‐cells. EBV cause B‐cell or T/NK lymphoproliferative (LPD) disorders EBV‐related haemophagocytic lymphohistiocytosis (HLH) 2 . These rare distinct diseases share clinical features of lymphadenopathy, fever, malaise, organomegaly night sweats 1 High levels DNA, as assessed by qPCR on whole blood plasma are typical but, per se have limited value. copy...