A5014017713- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Organ Transplantation Techniques and Outcomes
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver physiology and pathology
- RNA Research and Splicing
- Pancreatic and Hepatic Oncology Research
- Autophagy in Disease and Therapy
- Protein Tyrosine Phosphatases
- Endoplasmic Reticulum Stress and Disease
- Cancer Mechanisms and Therapy
- Virus-based gene therapy research
- CAR-T cell therapy research
- Immune cells in cancer
- Genomics, phytochemicals, and oxidative stress
- RNA Interference and Gene Delivery
First Affiliated Hospital of Anhui Medical University
2022-2025
Anhui Medical University
2022-2025
Nanjing Drum Tower Hospital
2018-2025
Nanjing Medical University
2015-2024
Southeast University
2020-2024
Nanjing University of Chinese Medicine
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Nanjing University
2019-2023
Jiangsu Province Hospital
2012-2022
Southeast University
2019-2021
Objective N 6 -methyladenosine (m A) RNA methylation and its associated methyltransferase METTL3 are involved in tumour initiation progression via the regulation of function. This study explored biological function clinical significance gastric cancer (GC). Design The prognostic value expression was evaluated using tissue microarray immunohistochemical staining analyses a human GC cohort. role mechanism growth liver metastasis were determined vitro vivo. Results level m A significantly...
Abstract Long noncoding RNAs play a pivotal role in T-helper cell development but little is known about their roles Treg differentiation and functions during the progression of hepatocellular carcinoma (HCC). Here, we show that lnc-epidermal growth factor receptor (EGFR) upregulation Tregs correlates positively with tumour size expression EGFR/Foxp3, negatively IFN-γ patients xenografted mouse models. Lnc-EGFR stimulates differentiation, suppresses CTL activity promotes HCC an EGFR-dependent...
Interleukin-22 (IL-22), one of the cytokines secreted by T helper 17 (Th17) cells, was recently reported to be a novel inflammation driver through STAT3 signaling activation. We aimed investigate role IL-22 expression in hepatocellular carcinoma (HCC). demonstrated significant up-regulation human HCC tumor infiltrated leukocytes (TILs) compared peripheral lymphocytes. Moreover, significantly higher Edmondson Grade III-IV patients versus I-II, confirmed both real-time polymerase chain...
Liver fibrosis is a severe, life-threatening clinical condition resulting from nonresolving hepatitis of different origins. IL-17A critical in inflammation, but its relation to liver remains elusive. We find increased expression fibrotic livers HBV-infected patients undergoing partial hepatectomy because cirrhosis-related early-stage hepatocellular carcinoma comparison with control nonfibrotic uninfected hepatic hemangioma. In livers, immunoreactivity localizes the inflammatory infiltrate....
Abstract Background Dynamic N 6 -methyladenosine (m A) modification was previously identified as a ubiquitous post-transcriptional regulation that affected mRNA homeostasis. However, the m A-related epitranscriptomic alterations and functions remain elusive in human cancer. Here we aim to identify profile outcome of A-methylation hepatocellular carcinoma (HCC). Results Using liquid chromatography-tandem mass spectrometry A-immunoprecipitation combination with high-throughput sequencing,...
Background/Aims: The alterations of long non-coding RNAs (lncRNAs) are related to multiple diseases. They can be detected in plasma as biomarkers for the diagnosis In this study, we aimed determine expression circulating lncRNAs human, which may promising hepatocellular carcinoma (HCC). Methods: Eight were chosen candidates on basis literature evaluate diagnostic value and accuracy lncRNA profiling system. candidate validated by qRT-PCR arranged training validation sets. Additional...
The early detection of hepatocellular carcinoma (HCC) presents a challenge because the lack specific biomarkers. Serum/plasma microRNAs (miRNAs) can discriminate HCC patients from controls. We aimed to identify and evaluate HCC‐associated plasma miRNAs originating liver as biomarkers for detecting HCC. In this multicenter three‐phase study, we first performed screening using both (HCC before after transplantation or hepatectomy) tissue samples (HCC, para‐carcinoma cirrhotic tissues). Then,...
The application of metabolomics in translational research suffers from several technological bottlenecks, such as data reproducibility issues and the lack standardization sample profiling procedures. Here, we report an automated high-throughput metabolite array technology that can rapidly quantitatively determine 324 metabolites including fatty acids, amino organic carbohydrates, bile acids. Metabolite identification quantification is achieved using Targeted Metabolome Batch Quantification...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic, aggressive cancer that frequently progresses and spreads by metastasis to the liver 1 . Cancer-associated fibroblasts, extracellular matrix type I collagen (Col I) support 2,3 or restrain progression of PDAC may impede blood supply nutrient availability 4 The dichotomous role stroma in PDAC, mechanisms through which it influences patient survival enables desmoplastic cancers escape limitation, remain poorly...
It has been previously reported that IL-22, one of the cytokines secreted by Th17 cells, demonstrates both a protective and inflammatory promotion effect in bowel disease (IBD) through STAT3 signaling activation. We sought to investigate role IL-22 expression colon cancer (CC).The related molecules were detected human CC, detail function mechanism investigated vivo vitro model.Our results demonstrated significant upregulation CC tumor infiltrated leukocytes (TILs) compared peripheral...
Abstract Location-associated long noncoding RNA (lncRNA) was reported to interact with target protein via a cis- regulatory process especially for the Flank10kb class lncRNA. Based on this theory, we aimed explore mechanisms of Linc00974 and KRT19 (an lncRNA beyond protein) when first confirmed aberrant expression in hepatocellular carcinoma previous study. Knockdown resulted an inhibition cell proliferation invasion activation apoptosis cycle arrest vitro , which also validated by...
// Jie Ji 1, * , Junwei Tang Lei Deng Yu Xie 1 Runqiu Jiang Guoqiang Li Beicheng Sun Liver Transplantation Center of the First Affiliated Hospital and Collaborative Innovation For Cancer Personalized Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, P.R. China These authors have contributed equally to this work Correspondence to: Sun, e-mail: sunbc@njmu.edu.cn Keywords: lncRNA, HCC, EpCAM, mTOR, prognosis Received: April 27, 2015 Accepted: October 16, Published: 26, ABSTRACT...
MEG3 as a tumor suppressor has been reported to be linked with pathogenesis of malignancies including hepatocellular carcinoma (HCC). However, the mechanism in HCC still remains unclear. In our study, aberrant decreased level 72 tissues obtained from patients and cell lines was examined by using real‐time PCR. The inhibition affection proliferation inducing apoptosis further confirmed vivo vitro, we also demonstrated that regulates partially via accumulation p53. Besides, hypermethylation...