A5101810975- Cholangiocarcinoma and Gallbladder Cancer Studies
- Viral-associated cancers and disorders
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Pancreatitis Pathology and Treatment
- Immunotherapy and Immune Responses
- Peptidase Inhibition and Analysis
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Cancer Mechanisms and Therapy
- Hepatocellular Carcinoma Treatment and Prognosis
- Whipple's Disease and Interleukins
- Ferroptosis and cancer prognosis
- Cytokine Signaling Pathways and Interactions
- Liver physiology and pathology
- Liver Disease and Transplantation
- Gallbladder and Bile Duct Disorders
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- NF-κB Signaling Pathways
- Listeria monocytogenes in Food Safety
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
Jiangsu Province Hospital
2011-2025
Nanjing Medical University
2011-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
First Hospital of Jilin University
2025
Jilin University
2025
The Wistar Institute
2025
University of Pennsylvania
2025
Academia Sinica
2024
Academy of Medical Sciences
2024
Wuxi People's Hospital
2019
Interleukin-22 (IL-22), one of the cytokines secreted by T helper 17 (Th17) cells, was recently reported to be a novel inflammation driver through STAT3 signaling activation. We aimed investigate role IL-22 expression in hepatocellular carcinoma (HCC). demonstrated significant up-regulation human HCC tumor infiltrated leukocytes (TILs) compared peripheral lymphocytes. Moreover, significantly higher Edmondson Grade III-IV patients versus I-II, confirmed both real-time polymerase chain...
It has been previously reported that IL-22, one of the cytokines secreted by Th17 cells, demonstrates both a protective and inflammatory promotion effect in bowel disease (IBD) through STAT3 signaling activation. We sought to investigate role IL-22 expression colon cancer (CC).The related molecules were detected human CC, detail function mechanism investigated vivo vitro model.Our results demonstrated significant upregulation CC tumor infiltrated leukocytes (TILs) compared peripheral...
Hydrogen sulfide (H2S) can protect the liver against ischemia-reperfusion (I/R) injury. However, it is unknown whether H2S plays a role in protection of hepatic I/R injury both young and old patients. This study compared protective effects rat model (young animals) mechanism underlying its effects. Young rats were assessed following an injection NaHS. NaHS alone reduced by activating nuclear erythroid-related factor 2 (Nrf2) signaling pathway, but had little effect on rats. pretreatment...
Previous reports have shown that IL-1α-MyD88-IL-6 signaling is essential in promoting hepatocellular carcinoma (HCC) development a diethylnitrosamine (DEN)-induced mouse model. We aimed to determine whether interleukin (IL)-1α regulates HCC humans.HBV-associated tissue, corresponding adjacent and normal tissue samples were obtained from 80 male 36 female patients. IL-1α, ERα, IL-6, MyD88 quantified by using real-time PCR Western blot. Stem-loop was used quantify miR-22 expression. Luciferase...
Norcantharidin (NCTD), a demethylated form of cantharidin, has been used as routine anticancer drug in China.In this study, the effect and mechanism NCTD on anti-hepatocellular carcinoma (HCC) was examined.In vivo antitumor activity investigated hepatoma-bearing mice by intraperitoneal injection different concentration NCTD.The levels MicroRNAs (miRNAs) mRNA were detected real-time PCR.The concentrations IL-10 IL-12 BMDMs, Raw 264.7 cells or tumor-associated macrophages (TAMs) measured with...
Epstein-Barr virus-encoded latent membrane protein 2A (LMP2A) promotes the epithelial-mesenchymal transition (EMT) of nasopharyngeal carcinoma (NPC), thereby increasing tumor invasion. Recently, dysregulation metastatic antigen 1 (MTA1) was found to enhance metastasis in a variety cancers. A molecular connection between these two proteins has been proposed but not firmly established. In this study, we reported overexpression MTA1 29/60 (48.3%) NPC patients, and significantly correlated with...
Oncogenic forms of HPV account for 4.5% the global cancer burden worldwide. This includes cervical, vaginal, vulvar, penile, and anal cancers, as well head neck cancers. As such, there is an urgent need to develop effective therapeutic vaccines drive immune system's cellular response against cells. One primary goals vaccination increase potency diversity anti-tumor T-cell responses; one strategy do so involves delivery full-length antigens scaffolded onto DNA-launched nanoparticles improve...
Abstract Melanoma is a highly aggressive skin cancer, especially diagnosed in advanced stages. While current treatments such as targeted therapies and immunotherapies have made promising progress, challenges like drug resistance limited effectiveness some patients persist. Therefore, ongoing development of novel therapies, particularly for late-stage melanoma, crucial. In this study, we explored the expression interleukin-13 receptor subunit alpha-2 (IL13Rα2) melanoma patient-derived...
Bone marrow mesenchymal stem cells (MSCs) have the potential to be used in cellular therapy of solid organs. However, tissue regeneration is limited by death transplanted cells. One main mechanisms cell organs through ischemia. In present study, we sought investigate whether a plant-derived antioxidant, berberine (BBR), could protect MSCs against apoptosis model ischemia consisting serum deprivation- and hypoxia-induced vitro. We also investigated mechanism(s) that may mediate action...
Abstract Background Although expression of MTA1 inversely correlates with the nuclear localization ERα, effect and molecular mechanism ERα regulation remain unknown. Methods Quantitative real-time PCR western blot analyses were used to measure levels MTA1. The on HCC cell proliferation invasion was assessed by EdU incorporation assays Transwell, respectively. ShRNA dual-luciferase investigate regulatory relationship between in lines. Results We found that gene may be influenced corepressors....
Abstract Hepatic steatosis (HS) can exacerbate acute pancreatitis (AP). This study aimed to investigate the relation between α1-antitrypsin (AAT) and when patients have HS. Using proteomic profiling, we identified 18 differently expressed proteins pots in serum of rats with or without HS after surgical establishment AP. AAT was found be one significantly down-regulated proteins. levels were lower hepatic (HSAP) than non-HSAP (NHSAP) (P < 0.001). To explore clinical significance these...
Lymph node metastasis (LNM) is a well-established prognostic factor for intrahepatic cholangiocarcinoma (ICC), but there are still some controversies relating to the evaluation of nodal status. Therefore, we investigated role lymph dissection (LND), compared performances different staging systems, and then developed validated nomogram predict cancer-specific survival (CSS) ICC patients.The study cohort was taken from Surveillance, Epidemiology, End Results database. Akaike information...
Background Hepatocellular carcinoma (HCC) is a highly heterogeneous tumor with several rare pathological subtypes and which still poorly understood. This study aimed to describe the epidemiological clinical spectrum of five HCC develop competing risk nomogram for cancer-specific survival prediction. Methods The cohort was recruited from Surveillance, Epidemiology, End Results database. clinicopathological data 50,218 patients histologically diagnosed classic (ICD-O-3 Histology Code =...
Abstract Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive cancer characterized by poor prognosis and resistance to chemotherapy. In this study, utilizing scRNA-seq, we discovered that the tetra-transmembrane protein mal, T cell differentiation 2 (MAL2), exhibited specific enrichment in ICC cells was strongly associated with prognosis. The inhibition of MAL2 effectively suppressed proliferation, invasion, migration. Transcriptomics metabolomics analyses suggested promoted lipid...
The evaluation of the nodal status hepatocellular carcinoma (HCC) is a classic but controversial topic. This study aimed to investigate incidence lymph node metastasis (LNM), explore role dissection (LND), and develop validate novel model predict LNM in patients with HCC, not other specified (NOS).The cohort was taken from Surveillance, Epidemiology, End Results database. annual percent change (APC) calculated using Joinpoint regression. Survival analyses adopted competing risk model....
Abstract Background Chronic hepatitis B virus (HBV) infection is an important cause of cirrhosis and hepatocellular carcinoma. The major challenges for current therapies are the low efficacy drugs occurrence drug resistant HBV mutations. RNA interference (RNAi) virus-specific genes offers possibility developing a new anti-HBV therapy. Recent reports have shown that lentiviral vectors based on HIV-1 promising gene delivery vehicles due to their ability integrate transgenes into non-dividing...
Non-alcoholic steatohepatitis (NASH) is characterized by excessive intracellular lipid accumulation, inflammation and hepatic insulin resistance. As the incidence of NASH increasing worldwide, there an urgent need to find novel interventional approaches. The pro-inflammatory cytokine IL-1β, generated released from Kupffer cells, considered initiate development NASH. AS-1, a synthetic low-molecule mimetic myeloid differentiation primary response gene 88 (MyD88), disrupts interaction between...