A5076793661- Nuclear Structure and Function
- RNA modifications and cancer
- RNA Research and Splicing
- Protein Degradation and Inhibitors
- PARP inhibition in cancer therapy
- interferon and immune responses
- Virus-based gene therapy research
- Ubiquitin and proteasome pathways
- Erythrocyte Function and Pathophysiology
- Endoplasmic Reticulum Stress and Disease
- Bacteriophages and microbial interactions
- Blood properties and coagulation
- RNA regulation and disease
- SARS-CoV-2 and COVID-19 Research
- Transgenic Plants and Applications
- Circular RNAs in diseases
- Molecular Biology Techniques and Applications
- Blood groups and transfusion
- Aquaculture disease management and microbiota
- Genomics and Phylogenetic Studies
- Chemical and Physical Studies
- Parkinson's Disease Mechanisms and Treatments
- Vaccine Coverage and Hesitancy
- Barrier Structure and Function Studies
- Plant Gene Expression Analysis
University of Pennsylvania
2023-2025
Translational Therapeutics (United States)
2024
Providence College
2020-2022
Red blood cells (RBCs) serve as natural transporters and can be modified to enhance the pharmacokinetics pharmacodynamics of a protein cargo. Affinity targeting Factor IX (FIX) RBC membrane is promising approach improve (pro)enzyme's pharmacokinetics. For targeting, purified human FIX was conjugated anti-mouse glycophorin A monoclonal antibody Ter119. The goal this study characterize activity FIX-Ter119 conjugate efficacy its loading on RBCs, well investigate biodistribution,...
Oncogenic forms of HPV account for 4.5% the global cancer burden worldwide. This includes cervical, vaginal, vulvar, penile, and anal cancers, as well head neck cancers. As such, there is an urgent need to develop effective therapeutic vaccines drive immune system's cellular response against cells. One primary goals vaccination increase potency diversity anti-tumor T-cell responses; one strategy do so involves delivery full-length antigens scaffolded onto DNA-launched nanoparticles improve...
The importance of cellular context to the synergy DNA damage response (DDR)-targeted agents is important for tumors with mutations in DDR pathways, but less well-established driven by oncogenic transcription factors. In this study, we exploit widespread transcriptional dysregulation EWS-FLI1 factor identify an effective DDR-targeted combination therapy Ewing sarcoma.
<div>AbstractPurpose:<p>The importance of cellular context to the synergy DNA damage response (DDR)-targeted agents is important for tumors with mutations in DDR pathways, but less well-established driven by oncogenic transcription factors. In this study, we exploit widespread transcriptional dysregulation EWS-FLI1 factor identify an effective DDR-targeted combination therapy Ewing sarcoma.</p>Experimental Design:<p>We used matrix drug screening evaluate between a...
<p>Supplementary Figures S1-S15 and Legends</p>
<div>AbstractPurpose:<p>The importance of cellular context to the synergy DNA damage response (DDR)-targeted agents is important for tumors with mutations in DDR pathways, but less well-established driven by oncogenic transcription factors. In this study, we exploit widespread transcriptional dysregulation EWS-FLI1 factor identify an effective DDR-targeted combination therapy Ewing sarcoma.</p>Experimental Design:<p>We used matrix drug screening evaluate between a...
<p>Supplementary Figures S1-S15 and Legends</p>
Parkinson’s Disease (PD) is the second most common neurodegenerative disease in humans. PD marked by Lewy body formation brain, which disturbs dopamine transfer system across neurons. Previous studies have shown that protein, α‐synuclein, a major contributor of bodies. In this study, we modeled α‐synuclein aggregation budding yeast, Saccharomyces cerevisiae. Using model, treated cells, separate trials, with phenylmethylsulfonyl fluoride (PMSF), sulforaphane (SFN), metformin, and methylene...
Despite the scientific ingenuity of their design, traditional SARS-CoV-2 mRNA vaccines are expensive and require ultracold freezers for storage that not available in many parts world. This makes them inaccessible to third world countries, no shelf stable, low-cost alternative currently exists. In response, we have constructed a novel COVID-19 vaccine delivery system using probiotic yeast Saccharomyces boulardii. We engineered plasmid express receptor binding domain SARS CoV-2 spike protein....
We isolated Aeromonas encheleia strain SOD01 from an urban freshwater stream in Providence, RI. De novo assembly of PacBio RSII data followed by polishing with Illumina MiSeq generated a complete 4,450,115 bp genome 61.8% GC content. PGAP annotation predicted 3,877 protein-coding genes, 127 tRNA, and 31 rRNA.