A5100397946- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Immune Cell Function and Interaction
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Immunotherapy and Immune Responses
- Esophageal Cancer Research and Treatment
- Organ Transplantation Techniques and Outcomes
- Liver physiology and pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Liver Disease and Transplantation
- RNA modifications and cancer
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- interferon and immune responses
- Health Systems, Economic Evaluations, Quality of Life
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Tracheal and airway disorders
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
Nanjing Medical University
2016-2025
Jiangsu Province Hospital
2016-2025
Kunming University of Science and Technology
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
Nanjing Normal University
2021-2024
National Institutes for Food and Drug Control
2024
First Affiliated Hospital of Jiangxi Medical College
2024
Shandong Provincial Hospital
2024
Shandong First Medical University
2023-2024
Nanchang University
2022-2024
IntroductionProgrammed death receptor-1 (PD-1) inhibitors have shown efficacy in first-line treatment of NSCLC; however, evidence PD-1 inhibitor as neoadjuvant is limited. This a phase 1b study to evaluate the safety and outcome setting.MethodsTreatment-naive patients with resectable NSCLC (stage IA–IIIB) received two cycles sintilimab (200 mg, intravenously, day 1 out 22). Operation was performed between 29 43. Positron emission tomography–computed tomography scans were obtained at baseline...
Background and Aims The development progression of hepatocellular carcinoma (HCC) is dependent on its local microenvironment. Tumor‐associated macrophages (TAMs) are deemed a key factor for the tumor microenvironment attribute to contribute aggressiveness. However, detailed mechanism underlying pro‐metastatic effect TAMs HCC remains undefined. Approach Results present study proved that were enriched in HCC. characterized by an M2‐polarized phenotype accelerated migratory potential cells...
Nonalcoholic steatohepatitis (NASH) is a chronic liver disease associated with dysregulation of metabolism and inflammation. G-protein coupled bile acid receptor 1 (TGR5) cell surface that involved in multiple metabolic pathways. However, the functions TGR5 regulating macrophage innate immune activation NASH remain unclear. Here, we found expression was decreased tissues from humans mice NASH. Compared to wild type (WT) mice, TGR5-knockout (TGR5-/-) exhibited exacerbated damage, increased...
Background Extensive research has established the significant correlations between cancer-associated fibroblasts (CAFs) and various stages of cancer development, including initiation, angiogenesis, progression, resistance to therapy. In this study, we aimed investigate characteristics CAFs in lung adenocarcinoma (LUAD) develop a risk signature predict prognosis patients with LUAD. Methods We obtained single-cell RNA sequencing (scRNA-seq) bulk RNA-seq data from public database. The Seurat R...
Abstract Objectives To compare the efficiency and safety of a novel flexible ureteral access sheath (f-UAS) traditional (UAS) during retrograde intrarenal surgery (RIRS). Patients methods Between January 2022 September 2022, total 152 consecutive cases with renal stones underwent RIRS f-UAS. Their outcomes were compared those another undergoing UAS using 1:1 scenario matched-pair analysis, matching parameters including age stone size. The f-UAS is 10-cm-long tube at tip that can follow bends...
Background: Preclinical models have suggested a role for sex hormones in the development of glioblastoma multiforme (GBM). However, impact gender on survival time patients with GBM has not been fully understood. The objective present study was to clarify association between and by analyzing population-based data.Methods: We searched Surveillance, Epidemiology, End-Results database who were diagnosed 2000 2008 treated surgery. Five-year cancer specific data obtained. Kaplan-Meier methods...
Abstract We explored the role of micro RNA ‐30a (miR‐30a) and mechanism involved in hepatic fibrosis. MiR‐30a overexpression was achieved by miR‐30a mimics transfection stellate cells ( HSC s) ‐T6, LX ‐2), agomir (ago‐miR‐30a) treatment mice. levels were measured using TaqMan mi assay system, localization detected fluorescence situ hybridization FISH ). The interaction Beclin1 confirmed dual‐luciferase reporter assay. Autophagic flux analysed tandem mRFP ‐ GFP LC 3 microscopy, electron...
The study aims to determine the efficacy and feasibility of a novel folate receptor (FR)-based circulating tumor cell (CTC) detection method in diagnosis non-small lung cancer (NSCLC). CTCs were collected from 3 ml blood based on negative enrichment by immunomagnetic beads then labeled conjugate tumor-specific ligand an oligonucleotide. After washing off redundant conjugates, bound conjugates removed analyzed quantitative polymerase chain reaction. captured cells validated as...
Stimulator of IFN genes (STING) is a central adaptor protein that mediates the innate immune responses to DNA virus infection. Although ubiquitination essential for STING function, how ubiquitination/deubiquitination system regulated by infection control activity remains unknown. In this study, we found USP21 an important deubiquitinating enzyme and it negatively regulates virus–induced production type I interferons hydrolyzing K27/63-linked polyubiquitin chain on STING. HSV-1 recruited at...
Background Current paradigms of anti-tumor therapies are not qualified to evacuate the malignancy ascribing cancer stroma’s functions in accelerating tumor relapse and therapeutic resistance. Cancer-associated fibroblasts (CAFs) has been identified significantly correlated with progression therapy Thus, we aimed probe into CAFs characteristics esophageal squamous (ESCC) construct a risk signature based on predict prognosis ESCC patients. Methods The GEO database provided single-cell RNA...
A Phase II study was undertaken to evaluate the safety and efficacy of neoadjuvant socazolimab, a novel PD-L1 inhibitor, in combination with nab-paclitaxel cisplatin for locally advanced esophageal squamous cell carcinoma (ESCC).Sixty-four patients were randomly divided between Socazolimab + (TP) arm (n = 32) control 32), receiving either socazolimab (5 mg/kg intravenously (IV), day 1) or placebo (125 mg/m2 IV, 1/8) (75 repeated every 21 days four cycles before surgery. The primary endpoint...
This study aimed to evaluate whether galectin-3 (Gal-3) contributes actively atrial fibrosis both in patients and experimental fibrillation (AF) models.Mouse HL-1 cardiomyocytes were subjected rapid electrical stimulation (RES) explore Gal-3 expression secretion levels by western blotting (WB) enzyme linked immunosorbent assay (ELISA). Neonatal rat cardiac fibroblasts treated with conditioned culture medium recombinant human the activation of transforming growth factor (TGF)-β1/α-smooth...
Drug-induced liver injury (DILI) is one of the major concerns during drug development. Wide acceptance 3 R principles and innovation in-vitro techniques have introduced various novel model options, among which three-dimensional (3D) cell spheroid cultures shown a promising prospect in DILI prediction. The present study developed 3D quadruple co-culture for prediction via self-assembly. Induction by phorbol 12-myristate 13-acetate at concentration 15.42 ng/mL 48 hours with following 24-hour...
Ischemia-reperfusion and chronic injuries associated with small-for-size liver transplantation (SFSLT) impair the regeneration of graft induce fibrosis. Mesenchymal stem cells (MSCs) can prevent development fibrosis, hepatocyte growth factor (HGF) also attenuate cirrhosis. Our previous studies have demonstrated that higher occurrence fibrosis existed in rats post-SFSLT, implantation HGF/MSCs, human HGF (hHGF)-expressing MSCs, improve regeneration, reduce mortality rats, as well potent...
BackgroundEsophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies with poor prognosis. Cancer-testis genes (CTGs) have been vigorously pursued as targets for cancer immunotherapy, but expressive patterns and functional roles CTGs remain unclear in ESCC.MethodsA systematic screening strategy was adopted to screen ESCC by integrating multiple public databases RNA expression microarray data from 119 subjects. For newly identified prognosis-associated CTGs, an...
As a pathological myocardial remodeling process in variety of cardiovascular diseases, cardiac hypertrophy still has no effective treatment. Human mesenchymal stem cells (hMSCs) derived extracellular vesicles (EVs) been recognized as promising treatment strategy for disease.In this study, the inhibitory effects on are compared between normoxia-conditioned hMSC-derived EVs (Nor-EVs) and hypoxia-conditioned (Hypo-EVs) neonatal rat cardiomyocytes (NRCMs) after angiotensin II (Ang II)...
Cancer vaccines generally are limited by insufficient tumor-specific cellular immunogenicity. Herein, a potent "ABC" ternary membrane-derived vaccine system blended from antigen-presenting mature dendritic cell membranes ("A"), bacterial E. coli cytoplasmic ("B"), and cancer ("C") is developed using block-copolymer micelle-enabled approach. The respective ABC membrane components provide for source of immune communication/activation enhanced accumulation in lymph nodes (A), immunological...
Introduction: To evaluate the feasibility and safety of using novel flexible vacuum-assisted ureteral access sheath (FV-UAS) in ureteroscopy (F-URS) treatment impacted non-distal stones. Methods: We analyzed data from patients who underwent FV-UAS for stones between January 2022 September 2023. Perioperative parameters were evaluated, including operative time, injury, complications. The have a 10 cm passive deflection segment at distal end that can bend following F-URS, while also being...