A5101880353- MicroRNA in disease regulation
- Bone fractures and treatments
- Cytomegalovirus and herpesvirus research
- Cancer-related molecular mechanisms research
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Medical Imaging and Analysis
- Liver physiology and pathology
- Circular RNAs in diseases
- Pelvic and Acetabular Injuries
- Orthopedic Surgery and Rehabilitation
- Meningioma and schwannoma management
- RNA modifications and cancer
- Blood groups and transfusion
- Anesthesia and Neurotoxicity Research
- Hip and Femur Fractures
- Liver Disease Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Erythrocyte Function and Pathophysiology
- Colorectal and Anal Carcinomas
- Toxoplasma gondii Research Studies
- Salivary Gland Disorders and Functions
- Neonatal and fetal brain pathology
- Neurofibromatosis and Schwannoma Cases
Shaoxing People's Hospital
2025
University of Hong Kong - Shenzhen Hospital
2024
University of Hong Kong
2024
Eighth Affiliated Hospital of Sun Yat-sen University
2018-2021
Sun Yat-sen University
2018-2021
Yangzhou University
2021
Affiliated Hospital of Nantong University
2018-2019
Nantong University
2018-2019
Second Affiliated Hospital of Nantong University
2018-2019
Cancer Hospital of Shantou University Medical College
2019
Abstract We explored the role of micro RNA ‐30a (miR‐30a) and mechanism involved in hepatic fibrosis. MiR‐30a overexpression was achieved by miR‐30a mimics transfection stellate cells ( HSC s) ‐T6, LX ‐2), agomir (ago‐miR‐30a) treatment mice. levels were measured using TaqMan mi assay system, localization detected fluorescence situ hybridization FISH ). The interaction Beclin1 confirmed dual‐luciferase reporter assay. Autophagic flux analysed tandem mRFP ‐ GFP LC 3 microscopy, electron...
The rebound characteristics of respiratory infections after lifting pandemic control measures were uncertain. From January to November 2023, patients presenting at a teaching hospital tested for common viruses and Mycoplasma pneumoniae using combination antigen, nucleic acid amplification, targeted next-generation sequencing (tNGS) tests. number rate positive tests per month, clinical microbiological analyzed. A rapid SARS-CoV-2 was followed by slower M. pneumoniae, with an interval 5 months...
In this study, we characterized the expression of 32 other kinesin superfamily proteins (KIFs) and analyzed their association with progression prognosis hepatocellular carcinoma (HCC).The data from 295 HCC patients The Cancer Genome Atlas were included in study. An independent t-test was used to compare KIF levels adjacent tissues. Pearson's Chi-square test assess relationships tumor biomarkers clinicopathological parameters. Kaplan-Meier plots log-rank tests analyze survival, univariate...
MicroRNAs (miRNAs) have been reported to be involved in many human cancers and tumor progression. The dysregulation of miR-449a is found types malignancies associated with growth, migration, invasion. However, its expression function non-small cell lung cancer (NSCLC) still remains unclear. In our study, was downregulated both NSCLC tissues lines, low obviously differentiation, TMN stage, poor overall survival (OS). Moreover, we demonstrated that could inhibit proliferation, invasion NSCLC....
To compare the bone cement diffusion and clinical effects between conventional percutaneous vertebroplasty(PVP) application of positioning reduction targeted puncture techniques in treatment elderly patients with osteoporotic vertebral compression fractures. A retrospective comparative study was conducted, analyzing data 268 single-level fractures admitted January 2021 March 2023. The were divided into two groups:the PVP group (138 cases) (130 cases). Among them, 138 treated by traditional...
Genome-wide sequencing investigations have identified numerous long noncoding RNAs (lncRNAs) among mammals, many of which exhibit aberrant expression in cancers, including esophageal squamous cell carcinoma (ESCC). Herein, this study elucidates the role and mechanism by LINC01419 regulates DNA methylation glutathione S-transferase pi 1 (GSTP1) relation to ESCC progression sensitivity cells 5-fluorouracil (5-FU).LINC01419 GSTP1 levels were quantified 38 paired adjacent tissue samples...
Introduction: MiRNAs have been proven to modulate the progression of gastric cancer (GC). In this field, we evaluated role and mechanism miR-140-3p in GC. Methods: Western blotting qRT-PCR were used detect levels BCL2. The interaction BCL2 was confirmed by dual-luciferase reporter miRNA pull-down assays. CCK-8, EdU, wound healing, Transwell invasion assays performed evaluate cell proliferation, migration invasion. Autophagy analyzed using blot analysis LC3-II/I ratio immunofluorescence...
To discusses the clinical effects of arthroscopy combined with minimally invasive percutaneous plate osteosynthesis(MIPPO) technology in treating Schatzker IV tibial plateau fractures.From January 2012 to 2016, 19 patients type fractures were treated technique including 12 males and 7 females an average age 46.5 years old ranging from 78 old. Patients suffering knee pain, swelling, flexion extension limited, other symptoms preoperative. followed up assessed by Rasmussen function score.No...
Background: Vasculogenic mimicry (VM) describes the functional plasticity of aggressive tumor cells to form newly recognized microcirculation, lined by rather than endothelial cells, in solid tumors. The presence VM glioma is significantly associated with high grade and poor prognosis. However, whether a regular feature or only temporary phenomenon during growth unknown. This study was designed observe subcutaneous orthotopic xenograft Balb/c nude mice. Methods: human glioblastoma cell line...
The present study examined kinetics of apoptosis and expression apoptosis-related proteins Bcl-2, Bax, caspase-3 in the CA3 hippocampus cells after diffuse brain injury (DBI) induced experimentally rats. Percentage apoptotic expressions above were by flow cytometry immunohistochemistry. Substantial neuronal was documented DBI (22.26 ± 2.97% at 72 h vs. 2.92 0.88% sham-operated animals). Expression Bc1-2 decreased, while Bax increased DBI, with peaking that (72 48 h, respectively). Further,...
Mismatch repair (MMR) deficiency can lead to constitutional mismatch (CMMRD) syndrome and Lynch (LS). These two genetic disorders are associated with a broad spectrum of tumor types, including variety brain tumors. Usually, tumors LS more common in adults rarely occur children. The characterizations café-au-lait macules (CALMs) relatively similar CMMRD neurofibromatosis type 1 (NF1), which often causes difficulties the diagnosis syndrome. We identified five patients MMR gene germline...
Objective To summarize the surgical techniques of Rathke's cleft cyst resection via fully endoscopic supraorbital trans-eyebrow keyhole approach and to evaluate its efficacy advantages disadvantages. Methods Twelve patients with confirmed by pathology at Department Neurosurgery, Nanfang Hospital, Southern Medical University from May 2012 October 2014 were analyzed retrospectively. The clinical manifestations included headache, visual impairment, polydipsia, polyuria, pituitary...
Objective To observe the expression of microRNA (miRNA, miR)-30a in liver fibrotic tissues and its effect on fibrosis. Methods Hepatic stellate cells (HSCs: LX-2, HSC-T6) were treated with 10 ng/ml transforming growth factor (TGF)-β1, C57BL/6 mice by bile duct ligation (BDL) (n=15), sham as control. MiR-30a mimics agomir transfected into HSCs mice, respectively. The levels miR-30a, α-smooth muscle actin (α-SMA), collagen Ⅰ, tissue inhibitor metalloproteinase 1 (TIMP-1) vivo vitro...
Copyright information: Taken from A mouse model of sitosterolemia: absence Abcg8/sterolin-2 results in failure to secrete biliary cholesterolBMC Medicine 2004;2():5-5.Published online 24 Mar 2004PMCID:PMC394351.Copyright © 2004 Klett et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution this article are permitted all media for any purpose, provided notice preserved along with the article's original URL. COS-1 cells were transiently...