A5015138178- SARS-CoV-2 and COVID-19 Research
- Infection Control and Ventilation
- SARS-CoV-2 detection and testing
- Respiratory viral infections research
- COVID-19 epidemiological studies
- Animal Virus Infections Studies
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Pneumonia and Respiratory Infections
- Viral Infections and Immunology Research
- Antifungal resistance and susceptibility
- COVID-19 and healthcare impacts
- Influenza Virus Research Studies
- Disaster Response and Management
- Infection Control in Healthcare
- Streptococcal Infections and Treatments
- Infectious Encephalopathies and Encephalitis
- Bacterial Infections and Vaccines
- COVID-19 and Mental Health
- Neonatal and Maternal Infections
- Antibiotic Resistance in Bacteria
- Rabies epidemiology and control
- COVID-19 impact on air quality
- Long-Term Effects of COVID-19
- Virus-based gene therapy research
Queen Elizabeth Hospital
2020-2025
Duchess of Kent Children's Hospital
2020-2024
Hospital Authority
2012-2021
Kowloon Hospital
2021
Tuen Mun Hospital
2009-2020
Ames Research Center
2016
Clinical Research Management
2013
Queen Mary Hospital
2004
University of Hong Kong
2004
Abstract The 2019 novel coronavirus (2019-nCoV) was detected in the self-collected saliva of 91.7% (11/12) patients. Serial viral load monitoring generally showed a declining trend. Live virus by culture. Saliva is promising noninvasive specimen for diagnosis, monitoring, and infection control patients with 2019-nCoV infection.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported from China in January, 2020. SARS-CoV-2 is efficiently transmitted person to and, months, has caused more than 82 000 laboratory-confirmed cases of disease 2019 (COVID-19) and 2800 deaths 46 countries. The total number surpassed that the 2003 severe (SARS-CoV). Although both COVID-19 (SARS) manifest as pneumonia, associated with apparently efficient transmission, fewer diarrhoea, increased mental confusion, a lower...
The Transiting Exoplanet Survey Satellite (TESS) will conduct a search for Earth's closest cousins starting in early 2018 and is expected to discover ∼1,000 small planets with R<sub>p</sub> < 4 R<sub>⊕</sub> measure the masses of at least 50 these worlds. Science Processing Operations Center (SPOC) being developed NASA Ames Research based on Kepler science pipeline generate calibrated pixels light curves Advanced Supercomputing Division's Pleiades supercomputer. SPOC also...
Coronavirus disease 2019 (COVID-19) was first reported in Wuhan December and has rapidly spread across different cities within outside China. Hong Kong started to prepare for COVID-19 on 31
Abstract Unlike Elizabethkingia meningoseptica , the clinical importance of E. anophelis is poorly understood. We determined and molecular epidemiology bacteremia caused by Elizabethkingia- like species from five regional hospitals in Hong Kong. Among 45 episodes -like bacteremia, 21 were including 17 three one miricola ; while 24 other diverse genera/species, as 16S rRNA gene sequencing. Of cases 15 (88%) clinically significant. The most common diagnosis was pneumonia (n = 5), followed...
To control the COVID-19 pandemic and prevent its resurgence in areas preparing for a return of economic activities, method rapid, simple, inexpensive point-of-care diagnosis mass screening is urgently needed. We developed evaluated one-step colorimetric reverse-transcriptional loop-mediated isothermal amplification assay (COVID-19-LAMP) detection SARS-CoV-2, using SARS-CoV-2 isolate respiratory samples from patients with (n = 223) other virus infections 143). The involves simple equipment...
Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has put tremendous pressure on the healthcare system worldwide. Diagnostic testing remained one of limiting factors for early identification and isolation infected patients. This study aimed to evaluate posterior oropharyngeal saliva (POPS) severe acute respiratory syndrome 2 (SARS-CoV-2) detection among patients with confirmed or suspected COVID-19. Methods laboratory information was searched retrospectively all specimens...
Abstract Background Healthcare workers (HCWs) use personal protective equipment (PPE) in Ebola virus disease (EVD) situations. However, preventing the contamination of HCWs and environment during PPE removal crucially requires improved strategies. This study aimed to compare efficacy three ensembles, namely, Hospital Authority (HA) Standard set (PPE1), Dupont Tyvek Model, style 1422A (PPE2), HA isolation gown for routine patient care performing aerosol-generating procedures (PPE3) prevent...
Abstract Background Post-vaccination myopericarditis is reported after immunization with coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccines. The effect of inadvertent intravenous injection this vaccine on the heart unknown. Methods We compared clinical manifestations, histopathological changes, tissue mRNA expression, and serum levels cytokine/chemokine troponin in Balb/c mice at different time points (IV) or intramuscular (IM) normal saline (NS) control. Results Although...
Abstract Background Nosocomial outbreaks with superspreading of coronavirus disease 2019 due to a possible airborne transmission have not been reported. Methods Epidemiological analysis, environmental samplings, and whole-genome sequencing (WGS) were performed for hospital outbreak. Results A event that involved 12 patients 9 healthcare workers (HCWs) occurred within days in 3 6 cubicles at an old-fashioned general ward no air exhaust built the cubicles. The contamination by severe acute...
During the investigation of a pet shop outbreak severe acute respiratory coronavirus 2 (SARS-CoV-2) with probable hamster-to-human transmission, environmental and hamster samples in epidemiologically linked shops were found positive for SARS-CoV-2 Delta variant AY.127 strains which are phylogenetically closely related to patients reported European strains. This interspecies' spill-over has triggered transmission 58 three shops. Incidentally, dwarf hamsters imported from Netherlands...
Abstract Background The role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the pathogenesis testicular damage is uncertain. Methods We investigated virological, pathological, and immunological changes testes hamsters challenged by wild-type SARS-CoV-2 its variants with intranasal or direct inoculation using influenza virus A(H1N1)pdm09 as control. Results Besides self-limiting tract infection, challenge caused decrease sperm count, serum testosterone inhibin B at 4–7...
The rebound characteristics of respiratory infections after lifting pandemic control measures were uncertain. From January to November 2023, patients presenting at a teaching hospital tested for common viruses and Mycoplasma pneumoniae using combination antigen, nucleic acid amplification, targeted next-generation sequencing (tNGS) tests. number rate positive tests per month, clinical microbiological analyzed. A rapid SARS-CoV-2 was followed by slower M. pneumoniae, with an interval 5 months...
Background. Healthcare laundry-related infection is rare, and pulmonary zygomycosis due to contaminated hospital linens has never been reported.
Several SARS-CoV-2 lineages with spike receptor binding domain (RBD) N501Y mutation have spread globally. We evaluated the impact of on neutralizing activity COVID-19 convalescent sera and anti-RBD IgG assays.The susceptibility to neutralization by patients' from Hong Kong were compared between two isolates (B117-1/B117-2) α variant 4 non-N501Y isolates. The effect antibody was assessed. performance commercially-available assays determined for patients infected variants.The...
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect human and other mammals, including hamsters. Syrian (Mesocricetus auratus) dwarf (Phodopus sp.) hamsters are susceptible to SARS-CoV-2 infection in the laboratory setting. However, pet shop-related Coronavirus Disease 2019 (COVID-19) outbreaks have not been reported. Methods We conducted an investigation of a COVID-19 outbreak due Delta variant AY.127 involving at least 3 patients Hong Kong. tested...
Nonpharmaceutical interventions implemented during the COVID-19 pandemic (2020–2021) have provided a unique opportunity to understand their impact on wholesale supply of antibiotics and incidences infections represented by bacteremia due common bacterial species in Hong Kong. The antibiotic data (surrogate indicator consumption) notifications scarlet fever, chickenpox, tuberculosis collected Centre for Health Protection, blood cultures patients admitted public hospitals Kong Hospital...
Abstract Background Long-range air dispersal of Candida auris has recently been described. Contact precautions alone may not be sufficient to target this mode transmission. Hence, we study the factors affecting extent environmental contamination including grilles in sporadic C. hospitalized patients, and outbreak settings. Study flow chart Methods Outbreaks cases involving two local hospitals from March October 2023 were retrospectively analysed. screening was performed for patients with...