A5100439702- SARS-CoV-2 and COVID-19 Research
- Atherosclerosis and Cardiovascular Diseases
- Influenza Virus Research Studies
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Animal Disease Management and Epidemiology
- Pharmaceutical and Antibiotic Environmental Impacts
- Infection Control and Ventilation
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- Herpesvirus Infections and Treatments
- Immune cells in cancer
- Indoor Air Quality and Microbial Exposure
- Bacteriophages and microbial interactions
- COVID-19 and healthcare impacts
- RNA Interference and Gene Delivery
- Long-Term Effects of COVID-19
- Essential Oils and Antimicrobial Activity
- Cardiovascular Disease and Adiposity
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- COVID-19 and Mental Health
- Virus-based gene therapy research
- Medicinal Plants and Neuroprotection
Hebei Agricultural University
2017-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2025
Qilu Hospital of Shandong University
2010-2025
Jiangnan University
2024-2025
State Key Laboratory for Innovation and Transformation of Luobing Theory
2025
Chinese PLA General Hospital
2025
Beijing Anzhen Hospital
2024
Capital Medical University
2024
Guangdong Pharmaceutical University
2024
University of Hong Kong
2022-2024
Pseudorabies virus (PRV) causes Aujeszky's disease in pigs and can be transmitted to other mammals, including humans. In the current study, we systematically studied interspecies transmission evolutionary history of PRV.We performed comprehensive analysis on phylodynamics, selection, structural biology summarize phylogenetic adaptive evolution PRV based all available full-length major glycoprotein sequences.PRV divided into 2 main clades with frequent interclade intraclade recombination....
The ongoing COVID-19 pandemic has continued to affect millions of lives worldwide, leading the urgent need for novel therapeutic strategies. G-quadruplexes (G4s) have been demonstrated regulate life cycle multiple viruses. Here, we identify several highly conservative and stable G4s in SARS-CoV-2 clarify their dual-function inhibition viral replication translation processes. Furthermore, cationic porphyrin compound 5,10,15,20-tetrakis-(N-methyl-4-pyridyl)porphine (TMPyP4) targeting shows...
CD4⁺CD25⁺ regulatory T cells (Tregs) mediate immune suppression and prevent autoimmune disorders. Recently, Tregs were found to present in atherosclerotic lesions play an important role the progression of atherosclerosis. Statins have immunomodulatory properties, effect statins on atherosclerosis depends part their mechanisms. We sought determine whether exhibit plaques peripheral circulation patients with acute coronary syndrome (ACS). In vivo experiment, we induced apolipoprotein...
Since December 2019, coronavirus disease (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has become a great challenge to the world's public health system. Nosocomial infections have occurred frequently in medical institutions worldwide during this pandemic. Thus, there is an urgent need construct effective surveillance and early warning system for pathogen exposure infection prevent nosocomial negative-pressure wards. In study, visualization construction of risk...
With a growing global concern over food safety and animal welfare issues, the livestock veterinary industries are undergoing unprecedented changes. These changes have not only brought challenges within each industry, but also opportunities for development. In this context, search natural safe products that can effectively replace traditional drugs has become an important research direction in fields of husbandry medicine. Oregano essential oil (OEO), as extract, is gradually emerging...
Atherosclerosis has been widely recognized as an inflammatory disease of the arterial wall in which macrophages play a major role. Yet, how macrophage-mediated pathology is regulated during atherosclerosis poorly understood. TNF-α-induced protein 8-like 2 (TIPE2, also known TNFAIP8L2) highly expressed resting and can negatively regulate inflammation through inhibiting immune receptor signaling. We report this article that TIPE2 plays crucial atheroprotective role likely by regulating...
Previous studies demonstrated that aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism, which eliminates ALDH2 activity down to 1%-6%, is a susceptibility gene for coronary disease. Here we investigated the underlying mechanisms based on our prior clinical and experimental studies. Male apoE-/- mice were transfected with GFP, ALDH2-overexpression ALDH2-RNAi lentivirus respectively (n=20 each) after constrictive collars placed around right common carotid arteries. Consequently, silencing led...
To date, intermediate hosts of SARS-CoV-2 remain obscure and controversial. Several studies have shown that SARS-CoV-2-related pangolin coronavirus (Pangolin-CoV) has a high sequence similarity to might be the initial source SARS-CoV-2; however, biological characteristics Pangolin-CoV are still largely unknown. In this study, we evaluated pathogenicity transmissibility in Syrian golden hamsters Mesocricetus auratus (Linnaeus, 1758) compared it with SARS-CoV-2. could effectively infect...
Several animal models have been used to assist the development of vaccines and therapeutics since COVID-19 outbreak. Due lack binding affinity mouse angiotensin-converting enzyme II (ACE2) S protein severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), increasing susceptibility mice SARS-CoV-2 infection was considered in several ways. Here, we generated a model expressing human ACE2 (hACE2) under control CAG promoter. Overexpression hACE2 did not pose significant effect on weight...
Hepatobiliary diseases have a high prevalence worldwide, with wide range of involved in the liver and biliary system. Modifications gut microbiota been proven to an association unbalanced intestinal homeostasis dysfunction host metabolism immune system, which can be risk factors for many hepatobiliary diseases, such as nonalcoholic fatty disease (NAFLD), alcoholic (ALD), steatohepatitis (NASH), hepatitis, cirrhosis, hepatocellular carcinoma (HCC) cholestasis, well infection due...
Previous studies have shown that B.1.351 and other variants extended the host range of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to mice. Sustained transmission is a prerequisite for viral maintenance in population. However, no evidence natural SARS-CoV-2 wild mice has been documented date. Here, we evaluated replication contact variant rats. The could infect replicate efficiently airways Furthermore, not be transmitted BALB/c or C57BL/6 but with moderate efficiency rats...
With the development of modern pig raising technology, increasing density animals in houses leads to accumulation microbial aerosols houses. It is an important prerequisite grasp characteristics bacteria different solve problems air pollution and disease prevention control This work investigated effects growth stages on bacterial aerosol concentrations communities Three traditional types closed were studied: farrowing (FAR) houses, weaning (WEA) fattening (FAT) The Andersen six-stage sampler...
Background Sepsis, causing serious organ and tissue damage even death, has not been fully elucidated. Therefore, understanding the key mechanisms underlying sepsis-associated immune responses would lead to more potential therapeutic strategies. Methods Single-cell RNA data of 4 sepsis patients 2 healthy controls in GSE167363 set were studied. The pseudotemporal trajectory analyzed neutrophil clusters under sepsis. Using hdWGCNA method, gene modules neutrophils explored. Multiple machine...
Influenza virus is a serious threat to global human health and public security. There an urgent need develop new anti-influenza drugs. Lentinan (LNT) has attracted increasing attention in recent years. As potential protective agent, LNT been shown have anti-tumor, anti-inflammatory, antiviral properties. However, there no further research into the action of lentinan vivo , mechanism still not fully understood. In this study, effect were studied Institute Cancer Research (ICR) mouse model....
COVID-19 was officially declared a global pandemic disease on 11 March 2020, with severe implications for healthcare systems, economic activity, and human life worldwide. Fast sensitive amplification of the acute respiratory syndrome virus 2 (SARS-CoV-2) nucleic acids is critical controlling spread this disease. Here, real-time reverse transcription recombinase-aided (RT-RAA) assay, targeting conserved positions in nucleocapsid protein gene (N gene) SARS-CoV-2, successfully established...