A5100325921- Extracellular vesicles in disease
- RNA modifications and cancer
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Parasitic Infections and Diagnostics
- Cancer-related gene regulation
- Hydrology and Watershed Management Studies
- Amoebic Infections and Treatments
- RNA Interference and Gene Delivery
- Catalytic C–H Functionalization Methods
- Artificial Intelligence in Games
- Immunotherapy and Immune Responses
- Aquaculture disease management and microbiota
- Immune cells in cancer
- Cyclopropane Reaction Mechanisms
- Neutrino Physics Research
- Topic Modeling
- Metabolomics and Mass Spectrometry Studies
- Digital Games and Media
- Orbital Angular Momentum in Optics
- Epigenetics and DNA Methylation
- Soil and Water Nutrient Dynamics
- Photonic and Optical Devices
- Water resources management and optimization
- Galectins and Cancer Biology
Tianjin Normal University
2021-2025
Macau University of Science and Technology
2014-2025
Shanxi Agricultural University
2025
Huazhong University of Science and Technology
2024-2025
Nanjing University
2008-2025
Huaiyin Institute of Technology
2025
Nanjing University of Chinese Medicine
2025
Jiangsu Province Hospital
2025
Minzu University of China
2024-2025
China Animal Health and Epidemiology Center
2024-2025
Abstract Exploring the epigenetic regulation mechanism of colorectal cancer (CRC) from perspective N6-methyladenosine (m6A) modification may provide a new target for tumor therapy. Analysis using high-throughput RNA-seq profile TCGA found that gene expression Methyltransferase-like 3 (METTL3) was significantly upregulated among 20 m6A binding proteins in CRC, which also validated CRC tissues and cell lines. Moreover, transcriptome sequencing METTL3 knockdown cells CRISPR/Cas9 editing...
Classifying different satellite remote sensing scenes is a very important subtask in the field of image interpretation. With recent development convolutional neural networks (CNNs), scene classification methods have continued to improve. However, use recognition based on CNNs challenging because background complex and many small objects often appear these scenes. In this letter, improve feature extraction generalization abilities deep so that they can learn more discriminative features, an...
Over 300 billion of cells die every day in the human body, producing a large number endogenous apoptotic extracellular vesicles (apoEVs). Also, allogenic stem cell transplantation, commonly used therapeutic approach current clinical practice, generates exogenous apoEVs. It is well known that phagocytic engulf and digest apoEVs to maintain body's homeostasis. In this study, we show fraction metabolized integumentary skin hair follicles. Mechanistically, activate Wnt/β-catenin pathway...
The exceptional architecture designed by master architects is a shared treasure of humanity, which embodies their design skills and concepts not possessed common architectural designers. To help ordinary designers improve the quality, we propose new artificial intelligence (AI) method for generative design, generates designs with specified styles architect quality through diffusion model based on textual prompts requirements. Compared to conventional methods dependent heavy intellectual...
Angiogenesis plays a pivotal role in tissue development and regeneration, but few safe efficient pro-angiogenic factors are available for long-term clinical therapy. Although stem cell-derived exosomes exhibit excellent biocompatibility considerable capacity, their low yield extremely limits potential. Exosome-mimetics (EMs) employ similar features to can be produced higher yield. In this study, the HY-EMs were enhance vitro vivo ability from hypoxia-preconditioned bone marrow mesenchymal...
With a growing global concern over food safety and animal welfare issues, the livestock veterinary industries are undergoing unprecedented changes. These changes have not only brought challenges within each industry, but also opportunities for development. In this context, search natural safe products that can effectively replace traditional drugs has become an important research direction in fields of husbandry medicine. Oregano essential oil (OEO), as extract, is gradually emerging...
Abstract Recently, the significant benefits of cancer immunotherapy for most cancers have been demonstrated in clinical and preclinical studies. However, efficacy these immunotherapies gliomas is limited, owing to restricted drug delivery insufficient immune activation. As carriers, exosomes offer advantages low toxicity, good biocompatibility, intrinsic cell targeting, which could enhance glioma efficacy. a review exosome-based systems has not presented. This introduces current problems...
In the pig industry, reproductive traits constantly influence production efficiency. To identify markers and candidate genes underlying porcine traits, a genome-wide association study (GWAS) was performed in Duroc population. total, 1067 pigs were genotyped using single-nucleotide polymorphism (SNP) chips, four including litter size at birth (LSB), weight (LWB), weaning (LSW), (LWW), examined. The results showed that 20 potential SNPs reached level of suggestive significance associated with...
Medulloblastoma (MB), the most common malignant pediatric brain tumor, is composed of at least four molecular subgroups with distinct clinical characteristics. The sonic hedgehog (SHH) subgroup exhibits abundant tumor-associated microglia/macrophages (TAMs) infiltration. SHH-MB patients treated by anti-SHH drugs showed high drug resistance. However, comprehensive role TAMs in remains enigma. aim this study to explore mechanism TAM activation/polarization and discover a potential...
Abstract The transcriptional regulation of aluminum (Al) tolerance in plants is largely unknown, although Al toxicity restricts agricultural yields acidic soils. Here, we identified a NAM, ATAF1/2, and cup-shaped cotyledon 2 (NAC) transcription factor that participates Arabidopsis (Arabidopsis thaliana). substantially induced the transcript protein levels ANAC070, loss-of-function mutants showed remarkably increased sensitivity, implying beneficial role ANAC070 plant to toxicity. Further...
Blastocystis is one of the most common zoonotic intestinal protozoa with global distribution and can cause gastrointestinal syndrome mainly characterized by diarrhea. School children are main susceptible population. No epidemiological data on among school in Hainan, only tropical island province China. Between March 2021 June 2023, 1973 fecal samples were collected from across three regions Hainan province. was examined amplifying small subunit ribosomal RNA (SSU rRNA) gene via polymerase...
Alterations in histone modification have been linked to cancer development and progression. Celastrol, a Chinese herbal compound, shows potent anti-tumor effects through multiple signaling pathways. However, the involvement of modifications this process has not yet illustrated. In study, barcode sequencing eukaryotic genome-wide deletion library revealed that modifications, especially acetylation associated with NuA4 acetyltransferase complex, were involved anti-proliferation actions...